Junctional Rhythm을 보인 한국형 출혈열 1례

이성원,이수훈,최대현,손영기,차광수,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

컴퓨터 단말기 업무자의 요통의 위험요인에 관한 연구

이철호,박정래,차애리,고광욱,김영욱,이수일 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

Low back pain in computer terminal operators is a very common but important symptom. While the occupational risk factors of low back pain were approved obscurely, there have been few studies on analysis or understanding of occupational risk factors. Therefore, we studied occupational risk factors of low back pain, especially for ergonomic factors as well as general characteristics of workers. We selected 98 subjects for this study, computer terminal operators ordinary using computers in Pusan. We calculated the subjective severity of low back pain of each operator by the Low Back Pain Scoring System. The relation of low back pain score to general characteristics of worker was also analyzed. We analyzed the relationship between low back pain score and individual efforts to prevent low back pain. We measured the ergonomic factors of each computer terminal operator-Trunk Inclination(TI), Arm Flexion(AF), Elbow Angle(EA), Head Tilting(HT), Knee Angle(KA), using of foot plate and gap between the popliteum and chair. The correlations between these ergonomic factors and low back pain score were then analyzed. And the results are as follows: 1. The prevalence rate of low back pain in computer terminal operators was 39.8% in this study, when low back pain score was converted by the low back pain scoring system. 2. According to general characteristics of workers related to low back pain, the scores were higher in the older age group, the married and the longer work carriers.(p<0.05) 3. In the analysis of the relationship between low back pain score and individual effort to prevent low back pain, regular exercise, history of schooling for prevention of low back pain, and declaration of intention to participate in low back pain education or exercise were stastistically significant(p<0.05). And the more severe the low back pain, the higher the intention to participate in low back pain education they had in this study. 4. In the analyses of relationships or correlations between low back pain score and each of the 7 categories of ergonomic factors, only head tilting had a weak reverse correlation with low back pain(r=0.2999, p<0.01). From now on, cohort studies for the risk factors of low back pain of workers, who have been forced to work in non-ergonomical positioning at the work site, will be necessary. On the background of these ergonomic studies, the occupational health profession should be required to manage ergonomic working conditions.

Identification of ultraviolet B radiation-induced microRNAs in normal human dermal papilla cells

CHA, HWA JUN,KIM, OK-YEON,LEE, GANG TAI,LEE, KWANG SIK,LEE, JAE HO,PARK, IN-CHUL,LEE, SU-JAE,KIM, YU RI,AHN, KYU JOONG,AN, IN-SOOK,AN, SUNGKWAN,BAE, SEUNGHEE SPANDIDOS PUBLICATIONS 2014 MOLECULAR MEDICINE REPORTS Vol.10 No.4

<P>Ultraviolet (UV) radiation impairs intracellular functions by directly damaging DNA and by indirectly generating reactive oxygen species (ROS), which induce cell cycle arrest and apoptosis. UV radiation can also alter gene expression profiles, including those of mRNA and microRNA (miRNA). The effects of UV radiation on cellular functions and gene expression have been widely documented in human skin cells such as keratinocytes, melanocytes and dermal fibroblasts, but the effect it has on other types of skin cell such as dermal papilla cells, which are crucial in the induction of hair follicle growth, remains unknown. In the current study, the effect of UV radiation on physiological changes and miRNA-based expression profiles in normal human dermal papilla cells (nHDPs) was investigated. UVB radiation of ≥50 mJ/cm<SUP>2</SUP> displayed high cytotoxicity and apoptosis in a dose-dependent manner. In addition, ROS generation was exhibited in UVB-irradiated nHDPs. Furthermore, using miRNA microarray analysis, it was demonstrated that the expression profiles of 42 miRNAs in UVB-irradiated nHDPs were significantly altered compared with those in the controls (35 upregulated and 7 downregulated). The biological functions of the differentially expressed miRNAs were studied with gene ontology analysis to identify their putative target mRNAs, and were demonstrated to be involved in cell survival- and death-related functions. Overall, the results of the present study provide evidence that miRNA-based cellular mechanisms may be involved in the UVB-induced cellular response in nHDPs.</P>

Design of CO₂ injection facility for geological storage in Pohang basin by process simulation

Su Ho Cha(차수호),Ji Yae Ahn(안지예),Miyoen Kim(김미연),Sung Ho Jin(진성호),Simon Scott Daniels,Kwang seok Oh(오광석) 한국신재생에너지학회 2015 한국신재생에너지학회 학술대회논문집 Vol.2015 No.11

우요골접근법에 의한 선택적 경동맥 조영술의 신뢰성과 안전성

차광수,김무현,김봉근,이수훈,박태호,김은택,김영대,김종성 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Clinical Significance of Spot Urine Specimen for Urine Collection and an Evaluation of Micro-Bumintest Compared to RIA for Microalbuminuria

Cha, Bong Yun,Kang, Moo Il,Lee, Kwang Woo,Hong, Kwan Su,Kang, Sung Koo,Yoon, Kun Ho,Son, Ho Young CATHOLIC MEDICAL CENTER 1991 Bulletin of the Clinical Research Institute Vol.19 No.1

Microalbuminuria may be a useful predictor of nephropathy in diabetes. Moreover, recent interventional studies have demonstrated that intensive insulin regimens may correct the increased albumin excretion in diabetes. Here we studied to determine whether single void urine samples can be used to estimate 24- hrs excretion and to evaluate the performance of Micro-Bumintest in screening for microalbuminuria in diabetic patients and compared with qualitative RIA determinations of the urinary albumin concentration. The results were as follows: 1. The overall correlation of spot urine with 24-hrs urine sample results expressed as microgram albumin per milligram creatinine was good (γ =0.54, p=0.0001) and also with 24 hrs urine microalbuminuria was good (γ=0.55, p=0.0001). 2. When 20 ㎍/min (24-hrs albumin excretion) was used as the upper limit of normal, the sensitivity and specificity of Micro-Bumintest in 24-hrs urine specimen were 93.8% and 64.7%. 3. BMI, serum creatinine and microalbuminuria were significantly associated between positive and negative Micro-Bumintest results (p<0.01, p<0.05, p<0.01). In summary, spot urine specimens are useful in estimating excretion in place of 24-hrs urine collections and the Micro-Bumintest is a reasonable screening method for microalbuminuria.

양육 역량 강화를 위한 액션러닝 프로그램 개발

박수홍(Su-Hong Park),정계숙(Gye-Sook Jung),유미숙(Mee-Sook Yoo),차지량(Jee-Ryang Cha),홍광표(Kwang-Pyo Hong) 중앙대학교 한국교육문제연구소 2013 한국교육문제연구 Vol.31 No.2

본 연구의 목적은 부모의 양육역량 강화를 위한 액션러닝 프로그램을 개발하는 것으로서 연구의 목적을 달성하기 위하여 문헌 및 사례연구를 통하여 양육역량을 함양하기 위한 선행 연구들의 문제점을 분석해 내고, 관련자들의 인터뷰를 통하여 본 프로그램 개발에 대한 요구조사를 실시하였다. 이를 바탕으로 프로그램을 개발하여 현장 적용을 실시하여 그 효과성을 검증하였다. 이를 바탕으로 개발된 프로그램은 핵심활동 프로세스, 시량, 수행목표, 핵심수행활동, 학습자의 지원요소, 핵심촉진활동, 퍼실리테이터 지원요소, 블렌딩 학습환경으로 구성하였다. 핵심활동 프로세스는 ‘사전강의’ → ‘팀 문제 개발하기’ → ‘문제 탐색하기’ → ‘문제 명료화하기’ → ‘가능한 해결책 도출하기’ → ‘우선순위 결정하기’ → ‘액션플랜 작성하기’ → ‘해결방안 실행하기’ → ‘성찰하기’ → ‘사후 활동하기’ 의 순으로 개발되었다. 개발된 프로그램은 B광역시 소재 학부모 지원센터의 도움을 얻어 영유아, 초등, 중등, 고등학교의 어머니들 각 4명씩, 총 16명을 대상으로 실제 적용을 하였으며, 문제해결과정에 대한 흥미도 향상, 실제적인 문제를 해결력 배양, 자녀 양육과 관련한 지식, 기술, 태도가 함양되는 효과를 확인할 수 있었다. The purpose of this study is to develop the program to enhance parenting competence. For this purpose, we studied parenting competence, parent participation education, and action learning of theoretical study. We also derived the current issue of parenting competence and the vision, direction, etc. of this research through the results of theoretical studies and interviews. Next, we built a concrete strategy of program activities based on the results of a needs analysis. The program, based on the results of the research, was composed of core activities process, times, performance goals, core performance activities, learner support elements, core promotion activities, facilitator support elements, and blended learning environments. Accordingly, we made the program and applied to some of the parents in B metropolitan city. As a result, it highlighted effectiveness – interest in improvement of program activities, requires continuous program activities, needs of themselves, enhancement of parenting competence, and a deeper understanding of children.

노력성 폐활량검사시 호흡기류센서의 보정기법

차은종(Cha, Eun-Jong),이인광(Lee, In-Kwang),장종찬(Jang, Jong-Chan),김성식(Kim, Sung-Shick),이수옥(Lee, Su-Ok),정재관(Jung, Jae-Kwan),박경순(Park, Kyung-Soon),김경아(Kim, Kyung-Ah) 한국산학기술학회 2009 한국산학기술학회논문지 Vol.10 No.5

노력성 폐활량(FVC) 검사시 호식기류의 최대값인 최고호기유량(PEF)은 호흡기능의 평가에 매우 중요하게 활용되는 진단 매개변수이다. PEF는 검사 초기에 매우 짧은 순간에 크게 증가하는 양상을 띠기 때문에 호흡기류센서의 동특성이 충분하지 않은 경우 측정오차가 발생한다. 본 연구에서는 노력성 호식기류 상의 초기 상승속도 (Sr)를 산출하고 Sr 값에 기초하여 센서 출력값을 보정하는 새로운 기법을 제안하였다. 미국 흉부학회(ATS)에서 제공하는 표준 기류신호 파형 26개를 생성하여(F) 속도계측형 호흡기류센서로 통과시키며 센서 출력신호(N)를 축적하였다. F의 최대값인 PEF와 N의 최대 값인 NPEF 간에는 당초 예상했던 대로 2차함수 관계가 성립하였으나(상관계수 0.9997), ATS파형 #2 및 26은 상당한 이탈을 보였다(상대오차>10%). NPEF의 상대오차와 Sr 간의 관계를 분석하여 상호 선형적인 관계를 얻었으므로, 이를 이용하여 보정한 결과 PEF 상대오차의 99% 신뢰구간이 약 2.5% 이었다. 이는 국제 표준인 ATS의 오차한계인 10%의 1/4 이내로써 매우 정확한 보정이 이루어졌다. 따라서 본 연구에서 제안하는 보정기법은 호흡기류센서 교정시 매우 유용하리라 판단된다. Peak expiratory flow rate(PEF) is a very important diagnostic parameter obtained from the forced vital capacity(FVC) test. The expiratory flow rate increases during the short initial time period and may cause measurement error in PEF particularly due to non-ideal dynamic characteristic of the transducer. The present study evaluated the initial rise slope(Sr) on the flow rate signal to compensate the transducer output data. The 26 standard signals recommended by the American Thoracic Society(ATS) were generated and flown through the velocity-type respiratory air flow transducer with simultaneously acquiring the transducer output signal. Most PEF and the corresponding output(NPEF) were well fitted into a quadratic equation with a high enough correlation coefficient of 0.9997. But only two(ATS#2 and 26) signals resulted significant deviation of NPEF with relative errors>10%. The relationship between the relative error in NPEF and Sr was found to be linear, based on which NPEF data were compensated. As a result, the 99% confidence interval of PEF error was turned out to be approximately 2.5%, which was less than a quarter of the upper limit of 10% recommended by ATS. Therefore, the present compensation technique was proved to be very accurate, complying the international standards of ATS, which would be useful to calibrate respiratory air flow transducers.

그레이브스 갑상선기능항진중 환자의 방사성옥소 ( 131I ) 치료에 있어 고정용량 10mCi 투여군과 일반적 계산용량 투여군의 3 년간 추적결과

이광우,강성구,손현식,한제호,강무일,손호영,차봉연,윤건호,유순집,홍관수 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.4

Radioiodine (131I) has been used for the treatment of Graves' hyperthyroidism since the late 1940's and is now generally regarded as the treatment of choice for Graves' hyperthyroidism who do not remit following a course of antithyroid drugs. But for the dose given, several different protocols have been described by different centres, each attempting to reduce the incidence of long-term thyroid failure while maintaining an acceptable rate of control of Graves' hyperthyroidism. To evaluate short-term follow up of fixed-dose and calculated-dose 131I therapy for Graves' hyperthyroidism, we studied clinical outcomes of 83 patients with Graves' hyperthyroidism treated with fixed-dose(10 mCi) or calculated-dose 131I therapy. The results were as follows: 1) The remission rate of Graves' hyperthyroidism was 81.3% in fixed-dose and 82.4% in calculated-dose group after 3 years of 131I ablation. 2) The cumulative incidence of hypothyroidism was not different between fixed-dose and calculated-dose group after 3 years of 131I ablation (Fixed-dose vs. calculated-dose: 28.6% vs. 17.8% at 1 year, 31.3% vs. 25.5% at 2 year, 40.6 vs. 29.2% at 3 years). 3) The remission rate or incidence of cumulative hypothyroidism after 3 years was not different between fixed-dose and calculated-dose group in each ages and sex, but all 3 patients less than 20 years old had fallen in hypothyroidism after 131I ablation. 4) There were no significant statistical differences of other related pretreatment variables (age, sex, thyroid function tests, RAIU, goiter size) between fixed-dose and calculated-dose group. In conclusion, there were no significant differences in remission rate and the incidence of hypothyroidism between the fixed-dose and the calculated-dose group. We suggest that noncalculated fixed low dose (6 mCi) radioiodine therapy could be given for the treatment of Graves' hyperthyroidism (J Kor Soc Endocrinol 7:358~363, 1992).

한국인 자가면역성 갑상선 질환 및 인슐린 의존형 당뇨병에서 HLA - DQA1 유전자형 분석

이광우,강성구,김동집,손현식,이종민,한제호,손호영,차봉연,강무일,윤건호,김춘추,유순집,홍관수,권혁호 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.4

Several autoimmune diseases are associated with the same human leukocyte antigen specificity. For example, insulin dependent diabetes mellitus, Graves' disease and Hashimoto's thyroiditis are associated with HLA-DR3. Avalysis of HLA-DR and DQ restriction fragment length polymorphisms indicate that the DQ subregion, which is linkage disequilibrium with DR loci, is more closely linked to the disease susceptibility genes. Recently association with the HLA-DQA1 locus has been described. Since no study on the HLA-DQA1 in autoimmune endocrine diseases has been done in Korea, this investigation was performed to demonstrate the pattern of HLA-DQA1 distribution in Korea Graves' disease, Hashimoto's thyroiditis and IDDM patients. After amplification of exon 2 DQA1 gene with polymerase chain reaction (PCR) procedure, we used non-radioactive HLA-DQA1 allele specific oligonucleotide (ASO) probes which labelled with horseradish peroxidase (HRP) coupled to the 5'end of the oligonucleotide for the HLA-DQA1 typing. The results were as follows; 1) The first domain of the DQA1 gene was amplified from minimum 1 ng of genomic DNA with use of the PCR. And from 1 g DNA sample, all the samples were successfully amplified which have a product of approximately 242 bp. 2) Only one specific probe was hybidized to each cell line, e.g. RH 83 probe to TAB(HLA-DQA1* 0103 homozygosity), GH 67 probe to DKB(HLA-DQA1*0301 homozygosity) and GH 66 probe to LUY(HLA-DQA1*0601 homozygosith). According to these results, we accurately determined HLA-DQA1 subtypes in study subjects. 3) Frequency of DQA1*0301 allele in Korean was high and DQA1*0201 allele was low compared to other populations. 4) In IDDM patients, DQA1*0301 allele was significantly increased (relative risk 6.6, p=0.03) compared with controls. However the frequencies of DQA1*0101, *0102, *0103 allele was decreased among patients (relative risk 0.28, p=0.02). 5) In Graves' disease and Hashimoto's thyroiditis, there was no statistically significant HLA-DQA1 alleles which was associated with disease susceptibility. These results suggest that HLA-DQA1*0301 allele is positively associated with IDDM and HLA-DQA1*0101, *0102, *0103 allele is negatively associated with IDDM in Korean as in other population.But in autoimmune thyroid disease, we can not find any HLA-DQA1 associations. (J Kor Soc Endocrinol 7:320~330, 1992)