http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sharma Suraj,Naskar Sweet,Kuotsu Ketousetuo 한국탄소학회 2020 Carbon Letters Vol.30 No.4
Our objective of this study is to design and develop a polyethylene glycol (PEG2000)-modifed multiwall carbon nanotube (PEGylated MWCNT) formulation for oral controlled metronomic chemotherapeutic drug delivery. Multiwall carbon nano�tubes undergo various chemical modifcations including oxidation with strong acids, conjugation of polyethylene glycol, and coating with cellulose acetate phthalate which resulted in the formation of aqueous dispersion and prevention of drug degradation in acidic environment. Advanced analytical procedure such as Fourier transform infra-red, X-ray difraction, diferential scanning calorimetry, thermal gravimetric analysis, transmission electron microscopy, and dynamic light scat�tering techniques were used to evaluate physicochemical characterization. We also performed in vitro cytotoxic study by MTT assay and results revealed that carboplatin-loaded PEGylated MWCNTs did not show signifcant detrimental efect on the viability of MDA-MB-231 (human breast cancer) cells. The maximum encapsulation and drug-loading capacity were determined to be 71.58±0.04 and 39.62±0.07%, respectively. The release of carboplatin from PEGylated MWCNTs was investigated at simulated intestinal fuid (SIF), pH 6.8, after optimizing at simulated gastric fuid (SGF), pH 1.2, by enteric coating. Enteric-coated PEGylated MWCNTs exhibit pH-responsive drug activity in a sustained manner especially at pH 6.8. This surface modifcation strongly suggests that PEGylated MWCNTs could be a potential carrier for metronomic chemotherapeutic agent for high drug resistance, drug with maximum adverse efect and poorly oral bioavailable drugs.