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각종 암종질환에서 혈청구리 및 아연농도의 변화에 관한 연구
김만우,오금탁,장경식,채종구,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1
The copper and zinc concentrations were measured in sera of 27 cases of hepatoma, 20 cases of stomach ca., 7 cases of esophageal ca., 12 cases of colorectal ca., 9 cases of lung ca., 18 cases of ovarian ca. and 48 cases of normal control in Chosun University Hospital from Jan. 1986 to July 1986. The results are as follows; 1. The mean concentration of copper in serum of normal control group was 96.0±5.02㎍/㎗ (Mean±2SE), in hepatoma, stomach ca., esophageal ca., colorectal ca., lung ca. and ovarian ca. concentrations were significantly increased each 126.4+12.77, 125.6±11.29, 140.5±14.23, 117.3±11.91, 181.4±30.56 and 130.5±13.80㎍/㎗ (P < 0. 001) in comparison with the mean value of normal control group. 2. The mean concentration of zinc in serum of normal control group was 104.8±3.40㎍/㎗ (Mean±2SE), in hepatoma and lung ca. concentrations were significantly decreased each 65.1±7.27 and 72.7±12.86 ㎍/㎗ (P < 0. 00l). 3. The ratio of serum copper level to zinc level (Cu/Zn ratio) in serum of normal control group was 0.94±0.057 in hepatoma, stomach ca., esophageal ca., lung ca. and ovarian ca. concentration ratios were significantly increased each 2.09±0.324, 1.86±0.122, 1.50±0.114, 2.55±0.513 and 1.51±0. 243 (P < 0.001).
Paraquat 투여 백서에서 Cyclophosphamide와 Dexamethasone의 치료 효과
신정철,신양수,유병전,임현성,정태흥,박찬국,오금탁,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
Paraquat (N,N'-dimethy 1-4,4'bipyrydinium : Gramoxone^(R), a widely used herbicide, is extremely toxic to all green plants and many eukaryotic organisms. In human, paraquat intoxication leads to multiple organ failure, it preferentially damages the lung, kidney and liver and may result in death. The participation of superoxide in initiating tissue damage by administration of paraquat is well known in which one electron reduction of paraquat leads to the formation of radical species which react with molecular oxygen to give superoxide. This process initiates immunological changes with the activation of neutrophilic leukocytes, which is related to further production of superoxide. In this experiment, therapeutic effects of cyclophosphamide and dexamethasone on blood cell count, malondialdehyde as a indicator of lipid peroxidation, and antioxidant enzymes levels in the lung, liver and kidney of paraquat intoxicated rats were inbestigated. The WBC count were significantly decreased by combined treatment of cyclophosphamide and dexamethasone in paraquat intoxicated rats at 3 and 5 days but RBC count were not changed. The contents of malondialdehyde were significantly decreased in the lung and Kidney by combined treatment at 10 days after paraquat intoxication. The catalase acitvities were markedly increased in the lung and liver of rats at 10 days after paraquat intoxication, and superoxide dismutase activities showed minimal changes in the lung, liver and kidney of rats by combined treatment. These results suggest that paraquat induced tissue damage in rats can be redeced by combined administration of cyclophosphamide and dexamethasone.
한금주(Kum Joo Han),안병철(Byeong Cheol Ahn),권중구(Joong Goo Kweon),김영탁(Young Tak Kim),금민수(Min Soo Kum),권영오(Young Oh Kweon),김성국(Seong Kook Kim),최용환(Yong Whan Choi),정준모(Joon Mo Chung) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
Objectives: In order to examine for one of the genetic predisposition to alcohol related liver disease, and for evaluation of their immunologic status, we studied HLA and delayed skin test in patients with alcoholic liver disease. Methods: A study of HLA in 50 patients with alcoholic liver disease(including 38 patients with liver cirrhosis) was conducted and delayed skin hyper-sensitivity to ubiquitous antigens was also tested in 46 patients with alcoholic liver disease. Results: 1) The comparison of the frequency of HLA-A2, A26, A34, B8, B48, B51, B60, B62 and DR3 between the patient group with alcoholic liver disease(N=50) and control group(N=196) showed higher values for the patients group, 78% vs 49%(p<0.0001), 18% vs 7.7% (p<0.05), 10% vs 0% (p<0.0001), 4% vs 0.5%(p,0.05), 10% vs 2%(p<0.01), 40% vs 7.7%(p<0.0001), 28% vs 9.7%(p<0.001), 34% vs 16.3%(p<0.01) and 24% vs 2.9%(p<0.0001) respectively. 2) The comparison of the frequency of HLA-A2, A26, A34, B8, B51, B60, B62 and DR3 between the patient group with aloholic liver cirrhosis(N=38) and control group(N=196) showed higher values in the patients group, 76.3% vs 43%(p<0.001), 21.1% vs 7,7%(p<0.01), 10.5% vs 0%(p<0.0001), 5.3% vs 0.5%(p<0.001), 36.8% vs 7.7%(p<0.0001), 28.9% vs 9.7%(p<0.001), 34.2% vs 16.3%(p<0.01) and 21.1% vs 2.9%(p<0.0001). 3) The data of delayed skin test with ubiquitous antigens did not show significant difference between the group of alcoholic liver disease(N=46) and that of normal control(N=20). Conclusion: Theses results suggest that genetic factor would be involved in the progression of the alcoholic liver disease but further studies are needed to evaluate the immunologic status in alcohnlic liver disease.
위 및 식도 정맥류 출혈시 경내경정맥 간내문맥간정맥 단락술의 치료효과
김영탁,김성국,정준모,김대현,최용환,권영오,권혁만,금민수,김용주 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.1
Background/Aims:Transjugular intrahepatic portosystemic shunt(TIPS) is a promising method of treatment for gastric and esophageall variceal bleeding. Immediate technical and short-term clinical results have been reportn!. This study is performed to evaluate long-term outcome after TIPS in patients who underwent the pracedure for variceal bleeding. Methods:Forty patients who underwent TIPS hetween August 1991 and February 199S were followed up by clinical examination, upper gastrointestina! Endoscopy and Duplex sonogrphy. Results:The mean portohepatic pressure gradient prior to TIPS was 30.1±8.7cmH2O ancl dropped to 16.6±6.7cmH2O after shunt(p$lt;0.001). The cumulative survival rate was 67.5% at 6 months. 57.4% at 1 year, 37.1% at 2 years and 26.8% at 3 years. Survival after TIPS was inversely related to Child-Pugh class. The incidence of recurrent variceal bleeding was 25%. The causes of death were hepatic failure(53.6 %), recurrent variceal bleeding(28.6'%), sepsis(7.1 %) and unknown causes(10.7'%). Conelueien:TIPS is an effective method for treatment of variceal bleeding in unsuccessful cases by other treatments including endoscopic therapy and the most important prognostic factor is preprocedual hepatic resenre(Child-Pugh class), TIPS by itself is not defioite therapy, but in combination with careful follow-up surveillance and percutaneous shunt revision is very effective therapeutic strategy. TIPS is particularly valuable in tlreating patients with variceal bleeding hefor liver transplantation and in treating patients with poor liver function.
탁태오,김금철,Tak, tae-oh,Kim, kum-Chul 강원대학교 산업기술연구소 1999 産業技術硏究 Vol.19 No.-
This paper presents a method for evaluating the performance of a leaf spring suspension and an air spring suspension systems for trucks in terms of ride and handling. Leaf springs, which generally have non-linear progressive force-deflection characteristics, are modeled using beam and contact elements. The leaf spring analysis model shows good correlation with experimental results. Each component of an air spring suspension system, which is a single leaf, air spring, height control valve, compressor and linkages, is modeled appropriately. Non-linear characteristics of air spring are accounted for using the measured data, and pressure and volume relations for height control system is also considered. The wheel rate of the air suspension is taken lower but roll stiffness is taken higher than those of leaf springs to improve ride and handling performance, which is verified through driving simulations.
사후 가토에서 Lithium의 혈중농도와 골수농도의 비교
김상도,오승상,배학연,오금탁,홍순표,조건국,양성훈 朝鮮大學校 附設 醫學硏究所 1988 The Medical Journal of Chosun University Vol.13 No.1
Blood is the usual specimen analyzed when concentration of a certain toxic chemical is to be investigated. However it is sometimes necessary to resort to other tissues if a satisfactory post mortem blood sample is unavailable or contaminated or damaged. Bone marrow is one of the tissues which may be useful in determining drug concentration, because it is highly vascularized and well protected within the bone. so, recently bone marrow has been examined as a specimen in toxicological studies. The post-mortem blood and bone marrow lithium concentrations were measured for the purpose of determining the relationship between lithium concentrations in both tissues. The rabbits which were given lithium carbonate in doses of 53, 106 and 159 (equivalent of lithium 10,20 and 30)㎎/㎏ were autopsied 0.5, 8 and 24 hours after sacrifice. The results were as follows. The overall mean bone marrow blood lithium ratio was 0.514±0.084. Bone marrow lithium concentration versus blood lithium concentration showed a linear relationship. The correlation coefficient was 0.994. This study showed that the blood lithium concentration could be estimated from the bone marrow concentrations of it.