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Sensory nerve and neuropeptide diversity in adipose tissues
Kristy L. Townsend,Gargi Mishra 한국분자세포생물학회 2024 Molecules and cells Vol.47 No.1
Both brown and white adipose tissues (BAT/WAT) are innervated by the peripheral nervous system, including efferent sympathetic nerves that communicate from the brain/central nervous system out to the tissue, and afferent sensory nerves thatcommunicate from the tissue back to the brain and locally release neuropeptides to the tissue upon stimulation. This bidirectional neural communication is important for energy balance and metabolic control, as well as maintaining adipose tissue healththrough processes like browning (development of metabolically healthy brown adipocytes in WAT), thermogenesis, lipolysis,and adipogenesis. Decades of sensory nerve denervation studies have demonstrated the particular importance of adiposesensory nerves for brown adipose tissue and WAT functions, but far less is known about the tissue’s sensory innervationcompared to the better-studied sympathetic nerves and their neurotransmitter norepinephrine. In this review, we cover what isknown and not yet known about sensory nerve activities in adipose, focusing on their effector neuropeptide actions in the tissue.
Sensory nerve and neuropeptide diversity in adipose tissues
Gargi Mishra,Kristy L. Townsend Korean Society for Molecular and Cellular Biology 2024 Molecules and cells Vol.47 No.2
Both brown and white adipose tissues (BAT/WAT) are innervated by the peripheral nervous system, including efferent sympathetic nerves that communicate from the brain/central nervous system out to the tissue, and afferent sensory nerves that communicate from the tissue back to the brain and locally release neuropeptides to the tissue upon stimulation. This bidirectional neural communication is important for energy balance and metabolic control, as well as maintaining adipose tissue health through processes like browning (development of metabolically healthy brown adipocytes in WAT), thermogenesis, lipolysis, and adipogenesis. Decades of sensory nerve denervation studies have demonstrated the particular importance of adipose sensory nerves for brown adipose tissue and WAT functions, but far less is known about the tissue's sensory innervation compared to the better-studied sympathetic nerves and their neurotransmitter norepinephrine. In this review, we cover what is known and not yet known about sensory nerve activities in adipose, focusing on their effector neuropeptide actions in the tissue.