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Association of 8q24.21 rs10505477-rs6983267 Haplotype and Age at Diagnosis of Colorectal Cancer
Haerian, Monir Sadat,Haerian, Batoul Sadat,Rooki, Hassan,Molanaei, Saadat,Kosari, Farid,Obohhat, Maedeh,Hosseinpour, Parisa,Azimzadeh, Pedram,Mohebbi, Seyed Reza,Akbari, Zahra,Zali, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Background: Colorectal cancer (CRC) is the fourth most common cause of cancer death in the world. Genetic variants in 8q24.21 including rs10505477 and rs6983267 have been hypothesized to be involved in susceptibility to CRC. This study aims to investigate the possible association between these loci and their haplotypes with CRC risk in Iranian population. Materials and Methods: Subjects were recruited from two hospitals in Tehran. The rs10505477 and rs6983267 polymorphisms were genotyped by TaqMan real time PCR using subject genomic DNA, extracted either from formalin-fixed, paraffin-embedded tissue of patients or from blood of the controls by standard methods. Results: A total of 715 subjects (380 CRC patients and 335 matched controls) were genotyped in this study. Allele and genotype analysis of the rs10505477 and rs6983267 polymorphisms by gender, age at diagnosis, tumor location, tumor grade, and tumor node metastasis (TNM) showed no significant association with CRC risk. There was a significant relationship between GG haplotype and susceptibility to age at diagnosis for both <60 and ${\geq}60$ (p=0.0005 and p=0.000004, respectively) and between GT and CRC in the age at diagnosis ${\geq}60$ (Table 3: p=0.031). The GG haplotype was less frequent in CRC patients with the age at diagnosis <60, but was more common in subjects with the age at diagnosis ${\geq}60$. Conclusions: Results of this study suggests that the rs6983267 and rs10505477 polymorphisms alone may not be relevant to CRC risk, but their GG haplotype plays a notable role in age at diagnosis of CRC in the Iranian population.
S. Hejazi,Sh. Mohajernia,M.H. Moayed,A. Davoodi,M. Rahimizadeh,M. Momeni,A. Eslami,A. Shiri,A. Kosari 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.25 No.-
Inhibitive performance of a new thiazolo-pyrimidine derivative has been investigated on mild steel in a solution of 1 M H2SO4. Electrochemical measurement, scanning electron microscope analysis and quantum chemical calculations are the tests and methods used to assess the performance of the inhibitors. The results indicate that the thiazolo-pyrimidine derivative used acts as a mixed-type inhibitor retarding the anodic and cathodic corrosion reactions. The studied compounds followed the Langmuir adsorption isotherm. Thermodynamic parameters showed that inhibitor adsorption is physical as determined by those parameters. The effect of molecular structure on the inhibition efficiency was investigated by quantum chemical calculations.