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Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
Dan Richard Laks,Koppany Visnyei,Harley Ian Kornblum 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.5
At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem cells may represent an essential cellular target for glioma therapy as they are postulated to be the tumorigenic cells responsible for recurrence. Targeting oncogenic pathways that are essential to the survival and growth of brain tumor stem cells represents a promising area for developing therapeutics. However, due to the multiple oncogenic pathways involved in glioma,it is necessary to determine which pathways are the essential targets for therapy. Furthermore, research still needs to comprehend the morphogenic processes of cell populations involved in tumor formation. Here, we review research and discuss perspectives on models of glioma in order to delineate the current issues in defining brain tumor stem cells as therapeutic targets in models of glioma.
Kim, Tae Cheol,Ojha, Shuchi,Tian, Guo,Lee, Seung Han,Jung, Hyun Kyu,Choi, Jun Woo,Kornblum, Lior,Walker, Frederick J.,Ahn, Charles H.,Ross, Caroline A.,Kim, Dong Hun The Royal Society of Chemistry 2018 Journal of materials chemistry. C, Materials for o Vol.6 No.20
<P>Self-assembled nanocomposites consisting of ferrimagnetic CoFe2O4 and ferroelectric BiFeO3 were grown on Nb-doped SrTiO3 (001) or SrTiO3-buffered Si (001) substrates using radio frequency magnetron sputtering. Spinel CoFe2O4 formed as epitaxial pillars within a perovskite BiFeO3 matrix, similar to nanocomposites grown by pulsed laser deposition. CoFe2O4 and BiFeO3 grew with a cube-on-cube epitaxy on Nb-doped SrTiO3, with partial relaxation of the in-plane strain of BiFeO3. The sputter-grown nanocomposites showed an out-of-plane magnetic easy axis as a result of both the shape anisotropy of the pillars and the magnetoelastic anisotropy of CoFe2O4, but the latter was dominant. The BiFeO3 matrix exhibited ferroelectric domains, and the removal of BiFeO3 led to the reduction of magnetic anisotropy by the strain relaxation of CoFe2O4. For potential application in devices, the nanocomposites were integrated on buffered silicon substrates. Templating of the CoFe2O4 nanopillars was achieved by substrate patterning. These techniques facilitate the incorporation of multiferroic nanocomposites into memory and other devices.</P>