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Kai Bin Liew,Kok Khiang Peh 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
Orally disintegrating tablet (ODT) is a userfriendly and convenient dosage form. The study aimed toinvestigate the effect of polymers and wheat starch on thetablet properties of lyophilized ODT, with dapoxetine asmodel drug. Three polymers (hydroxypropylmethyl cellulose,carbopol 934P and Eudragit EPO) and wheat starchwere used as matrix forming materials in preparation oflyophilized ODT. The polymeric dispersion was casted intoa mould and kept in a freezer at -20 C for 4 h beforefreeze dried for 12 h. It was found that increasing in HPMCand Carbopol 934P concentrations produced tablets withhigher hardness and longer disintegration time. In contrast,Eudragit EPO was unable to form tablet with sufficienthardness at various concentrations. Moreover, HPMCseems to have a stronger effect on tablet hardness comparedto Carbopol 934P at the same concentration level. ODT of less friable was obtained. Wheat starch acted asbinder which strengthen the hardness of ODTs and prolongedthe disintegration time. ODT comprising of HPMCand wheat starch at ratio of 2:1 was found to be optimumbased upon the tablet properties. The optimum formulationwas palatable and 80 % of the drug was released within30 min in the dissolution study.