관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

황해 폐기를 투기해역(서해병) 표층 퇴적물의 금속원소 분포

고혁준 ( Hyuk Joon Koh ),최영찬 ( Young Chan Choi ),박성은 ( Sung Eun Park ),차형기 ( Hyung Kee Cha ),장대수 ( Dae Soo Chang ),이충일 ( Chung Il Lee ),윤한삼 ( Han Sam Yoon ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.7

The aim of this study was to investigate the accumulation of metallic elements and the control effect of marine pollution caused by ocean dumping in the sediments at a waste disposal area in the Yellow Sea. In July 2009, concentrations of organic matter and metallic elements (Al, Fe, As, Cd, Cr, Co, Hg, Ni, Mn, Pb, and Zn) were measured in surface sediments at the site. The ignition loss (IL) in the surface sediments showed a mean value of 15.4%, about 1.5 times higher than the mean value of the sediments in the coastal areas of Korea. The chemical oxygen demand (COD) at some disposal sites exceeded 20 ㎎ O2/gㆍdry. Which signifies the initial concentration of marine sediment pollutants in Japan. The disposal sites contain higher concentrations of Cr, Cu and Zn than the sediments of bays and estuaries that might be contaminated. The magnitude of both metal enrichment factors (EF) and adverse biological effects suggest that pollution with Cr and Ni occurred due to the dumping of waste in the study area. In addition, the geoaccumulation index (Igeo) showed that the surface sediments were moderately contaminated. By the mid-2000s, when the amount of waste dumped at this site was the highest, the concentration of metallic elements was higher than ever recorded. On the other hand, in 2008-09, the need for environmental management was relatively low compare with the peak. As a result, the quality of marine sediment has been enhanced, considering the effect of waste reduction and natural dilution in the disposal area.

한국 서해 폐기물 투기해역의 하계 수질인자 분포특성과 장기 투기행위로 인한 영양염 농도 변화

고혁준 ( Hyuk Joon Koh ),최영찬 ( Young Chan Choi ),박성은 ( Sung Eun Park ),차형기 ( Hyung Kee Cha ),장대수 ( Dae Soo Chang ),윤한삼 ( Han Sam Yoon ),이충일 ( Chung Il Lee ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.11

This paper focuses on the impacts of waste dumping on inorganic nutrients in the dumping area of the Yellow Sea, and the effect of an governmental regulation of pollution in dumping areas. The environmental variables and parameters of the dumping and reference areas in the Yellow Sea were measured during July 2009 and analyzed. In addition, the analyzed data for inorganic nutrients over the last 10 years were obtained from the Korea Coast Guard (KCG) and the National Fisheries Research and Development Institute (NFRDI). The chemical environment of the study area revealed increases in concentrations of inorganic nutrients, Chemical Oxygen Demand (COD), and Volatile Suspended Solids (VSS) in the bottom layer. On the contrary, the pH level was decreased. Most notably, the time series data of inorganic nutrients showed gradual increase over time in the dumping area, and thus, the oligotrophic waters trend toward eutrophic waters. The increases appears to be due to the disposal of large amounts of organic waste . In recent times, the wastes disposed at the area were largely comprised of livestock wastewater, and food processing waste water. The liquefied waste, which contains an abundance of nutrients, causes a sharp increase in concentrations of inorganic nitrogen in the dumping area. On the one hand, the dumping sites have been deteriorated to such an extent that pollution has become a social problem. Consequentially, the government had a regulatory policy for improvement of marine environmental since 2007 in the dumping area. Hence, the quality of marine water in the dumping site has improved.

Parametric study of lateral stability for a railway vehicle

Joon-Hyuk Park,Hyo-In Koh,Nam-Po Kim 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.7

This paper deals with the lateral stability for a railway vehicle. Particularly, nonlinear critical speed is investigated via bifurcation analysis. Shooting method and trust region algorithm are applied to calculate the limit cycle of the nonlinear dynamic vehicle model. In case of the investigated vehicle model, the influences of the suspension parameters on the critical speeds are not large. The effects of friction coefficient are also small. However, there is an overall consistency that the nonlinear critical speed is decreased when the stiffness of the suspension is reduced. Study of the excitation conditions where the stable limit cycles occur gives very useful information to understand the nonlinear dynamic behavior of a railway vehicle and to test the vehicle with roller rig test stands. According to the results, the direction of the excitation is very important as well as the amplitude and frequency to acquire accurate nonlinear critical speed.

The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation

( Hyuk Kim ),( Kui Young Park ),( Sun Young Choi ),( Hyun Ju Koh ),( Sun Young Park ),( Won Seok Park ),( Il Hong Bae ),( Beom Joon Kim ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. Objective: The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections. Methods: A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS). Results: In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone. Conclusion: A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation. (Ann Dermatol 26(4) 447~456, 2014)

Instability Analysis in Curve Noise of Urban Railway Systems for Optimal Steering Bogie Development

Koh, Hyo-In,Park, Joon-Hyuk ASME International 2011 Journal of vibration and acoustics Vol.133 No.6

Orbicularis oris muscle reconstruction and cheiloplasty with Z-plasty in a patient with a transverse facial cleft

Koh, Sung-Hyuk,Jeong, Yeon-Woo,Han, Jeong Joon,Jung, Seunggon,Kook, Min-Suk,Oh, Hee-Kyun,Park, Hong-Ju Korean Association of Maxillofacial Plastic and Re 2019 Maxillofacial Plastic Reconstructive Surgery Vol.41 No.-

Background: Transverse facial clefts are Tessier's number 7 facial cleft among numbers 1-15 in Tessier's classification of craniofacial malformations, which varies from a simple widening oral commissure to a complete fissure extending towards the external ear. Case presentation: In a patient with a transverse facial cleft, to functionally arrange the orbicularis oris muscle and form the oral commissure naturally, we performed a surgical procedure including orbicularis oris muscle reconstruction and cheiloplasty with Z-plasty. Conclusion: We achieved good results functionally and esthetically by orbicularis oris muscle reconstruction and cheiloplasty with Z-plasty. The surgical modality of our anatomical repair and 3 months follow-up results are presented.

Basilar Artery Plaque and Pontine Infarction Location and Vascular Geometry

Bum Joon Kim,Kyung Mi Lee,Hyun Young Kim,Young Seo Kim,Seong-Ho Koh,Sung Hyuk Heo,장대일 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1

Background and Purpose Subclinical atherosclerotic plaques are common in patients with pontine infarctions (PIs) but without basilar artery (BA) stenosis. We hypothesized that BA plaque locations may differ by PI type and vertical location as well as vertebrobasilar artery geometry. Methods Ninety-six patients with PI but without BA stenosis on magnetic resonance imaging (MRI) and magnetic resonance angiography were enrolled. PIs were classified by type (paramedian, deep, or lateral) and vertical location (rostral, middle, or caudal). Patients underwent highresolution MRI to evaluate BA plaque location (anterior, posterior, or lateral). The mid-BA angle on anteroposterior view and angle between the BA and dominant vertebral artery (BA-VA angle) on lateral view were measured. Results The PIs were paramedian (72.9%), deep (17.7%), and lateral (9.4%) type with a rostral (32.3%), middle (42.7%), and caudal (25.0%) vertical location. The BA plaque locations differed by PI type (P=0.03) and vertical location (P<0.001); BA plaques were most frequent at the posterior wall in paramedian (37.1%) and caudal (58.3%) PIs and at the lateral wall in lateral (55.5%) and middle (34.1%) PIs. The BA-VA and mid-BA angles differed by BA plaque and PI vertical location; the greatest BA-VA angle was observed in patients with posterior plaques (P<0.001) and caudal PIs (P<0.001). Greatest mid-BA angles were observed with lateral BA plaques (P=0.03) and middlelocated PIs (P=0.03). Conclusions Greater mid-BA angulation may enhance lateral plaque formation, causing lateral and middle PIs, whereas greater BA-VA angulation may enhance posterior plaque formation, causing paramedian or caudal PIs.

Design and analysis of an active steering bogie for urban trains

Park, Joon-Hyuk,Koh, Hyo-In,Hur, Hyun-Moo,Kim, Min-Soo,You, Won-Hee 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.6

The conventional railway vehicle was designed to ensure running stability using high stiffness elements for primary suspensions. Curving performance of the railway vehicle is relatively low because the natural steering motion of a wheelset is constrained by the high stiffness suspensions. High running stability has always been in conflict with good curving performance in conventional design processes. This conflict problem can be solved with an active steering bogie since active elements properly control the wheelset motions according to track conditions such as straight or curved lines. In this paper, an active steering mechanism for railway vehicle is introduced, and the curving performance of the proposed active steering bogie is investigated through simulation and experiments. According to the results, the proposed active steering bogie is highly effective for curve negotiation.

만성 기능성 변비 환자에서 락툴로오스 제제가 대장 통과시간 및 증상 개선에 미치는 효과

이준성 ( Joon Seong Lee ),김영대 ( Yong Dae Kim ),임희혁 ( Hee Hyuk Im ),조영만 ( Young Man Cho ),정인섭 ( In Seop Jung ),고봉민 ( Bong Min Koh ),홍수진 ( Su Jin Hong ),유창범 ( Chang Bum Ryu ),김진오 ( Jin Oh Kim ),조주영 ( Joo Y 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2

목적: 기능성 변비환자를 대상으로 락툴로오스 제제의 대장 운동능 개선효과 및 변비증상 개선효과를 평가하고자 하였다. 대상 및 방법 : 로마진단기준 II에 의한 만성 기능성 변비 환자 15명에서 대장통과 신티그래피를 시행한 후 7일간 락툴로오스 45-60 ㎖를 투여하고 다시 신티그래피 검사를 하여 약물 투여 전과 비교하였다. 환자는 매일 배변일기를 작성하였고, 순위척도 및 변형된 사각상사척도로 평가한 각 변바 증상의 정도 및 빈도 변화를 약물 투여 전후를 비교 검토하였다. 최종 치료 후 전반적인 변비 개선도에 대한 환자 자신의 평가를 시각상사척도로 시행하였다. 결과: 신티그래피에서 근위부 결장의 절반 배출시간은 40.5±22.0시간에서 약물 투여 중 32.2±14.5시간으로 감소하는 경향을 보였으나 그외 다른 지표에서 차이는 없었다. 대장통과지연형 변비환자 5명에서는 GC48 (2.61±0.61 vs. 3.43±1.04)가 약물투여로 유의한 증가를, 근위부 결장의 절반 배출 시간(63.5±23.2 vs. 38.9±20.1)과 상행 결장의 절반 배출시간(24.3±11.6 vs. 15.5±6.7)은 약물투여로 유의한 감소를 보였다(p<0.05). 배변 횟수(3.8±l.3/w vs. 6.9±3.3/w), 대변 형태(변형된 Bristol 분류 2.5±0.6 vs. 4.5±1.1), 배변 과정 시 난이도(3.3±0.5 vs. 4.1±0.9)는 약물투여로 유의한 개선을 보였다(p<0.05). 배변시 과도한 힘주기, 배변시 항문이 막힌 느낌, 단단한 대변 횟수에 대한 증상의 빈도와 정도는 모두 약물 투여로 유의한 감소를 보였다 (p<0.05). 환자가 직접 주관적 판단에 의해 VAS로 평가한 변비증상의 전반개선률은 58±23%이였다. 결론: 락툴로오스는 가능성 변비환자의 대부분의 증상을 호전시키므로 효과적이고 안전하게 사용할 수 있는 약물로 생각한다. 특히 대장통과 지연형 환자에 있어서 이와 같은 증상의 호전은 대장 통과시간의 개선에 따른 것으로 생각한다. Background/Aims: We wanted to evaluate the effect of lactulose on the various symptoms of constipation and colon transit in patients suffering with functional constipation. Methods: Colon transit was measured by scintigraphy before and 1 week after lactulose treatment (45-60 ㎖/day) in 15 female patients with functional constipation. The frequency and severity of constipation symptoms were measured by using an ordinary scale and daily diaries. Results: There was no significant difference in the geometric centers before and after treatment. Only the t1/2 of the proximal colon tended to be shortened after treatment. In 5 patients with slow transit constipation, lactulose accelerated colonic transit at 48 hours (GC48: 2.6±0.6 vs. 3.4±1.0, p<0.05) and there was reduction of the t1/2 for proximal colonic emptying (63.5±23.2 h vs. 38.9±20.1 h, p<0.05). Lactulose increased stool frequency (3.8±1.3/wk vs. 6.9±3.3/wk, p<0.05), changed the form of the stool (p<0.05), facilitated passage of stool (p<0.01), and improved the frequency and severity of straining, the sensation of anorectal obstruction and the sensation of incomplete evacuation in 15 constipated patients (p<0.05). Conclusions: Lactulose improved most of the constipation symptoms in the patients suffering with functional constipation. In the patients with slow transit constipation, these improvements of symptoms may be due to acceleration of the proximal colonic transit via lactulose. (Kor J Neuro-gastroenterol Motil 2006;12:127-135)