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Impact of Severe Cervical Foraminal Stenosis on Contralateral C7 Nerve Transfer Outcomes
Youngjoon Kim,Seondeuk Kim,Seungae Kim,Hyung-Min Kwon 대한신경초음파학회 2023 대한신경초음파학회지 (JNN) Vol.15 No.1
This report presents the case of a 67-year-old male patient with severe bilateral C6/7 foraminal stenoses who underwent contralateral seventh cervical nerve (C7) transfer as a treatment for left spastic hemiparesis resulting from a right middle cerebral artery infarction. The initial postoperative results showed improved spasticity and motor function, but these gains plateaued and even receded, unlike other studies that noted progress at 10–18 months post-surgery. We hypothesized that the presence of C7 radiculopathy due to severe cervical foraminal stenosis may affect long-term outcomes after contralateral C7 transfer and serve as a contraindication for this surgery. These findings emphasize the importance of thoroughly assessing patients with cervical foraminal stenosis and the associated risk of radiculopathy before considering a contralateral C7 transfer. Further research is needed to assess the prevalence of cervical foraminal stenosis in patients undergoing contralateral C7 transfer and explore alternative surgical approaches or adjunctive treatments to optimize postoperative outcomes.
JaeMin Kim,KyungYeol Bae,HeeJu Kang,SungWan Kim,IlSeon Shin,YoungJoon Hong,JuHan Kim,HeeYoung Shin,YoungKeun Ahn,JongKeun Kim,MyungHo Jeong,JinSang Yoon 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.1
Depression is common after acute coronary syndrome (ACS), adversely affecting cardiac course and prognosis. There have been only a few evidence-based treatment options for depression in ACS. Accordingly, we planned the Korean Depression in ACS (K-DEPACS) study, which investigated depressive disorders in patients with ACS using a naturalistic prospective design, and the Escitalopram for DEPACS (EsDEPACS) trial, which assessed the efficacy and safety of escitalopram for treating major or minor depression in patients with ACS. Participants in the K-DEPACS study were consecutively recruited from patients with ACS who were recently hospitalized at Chonnam National University Hospital, Gwangju, South Korea. Diagnoses were confirmed by coronary angiography from 2005. Data on depressive and cardiovascular characteristics were obtained at 2 weeks, 3 months, 12 months, and every 6 months thereafter following the index ACS admission. The K-DEPACS participants who met the DSM-IV criteria for major or minor depressive disorder were randomly assigned to groups in the 24-week, double-blind, placebo-controlled EsDEPACS trial beginning in 2007. The outcome of treatments for depressive and other psychiatric symptoms, issues related to safety, including general adversity, and cardiovascular factors were assessed. The K-DEPACS study can significantly contribute to research on the complex relationships between depression and ACS. The results of the EsDEPACS trial provide an additional treatment option for clinicians treating these patients.
Choi, HongRan,Lim, WonBong,Kim, InAe,Kim, JiSun,Ko, YoungJong,Kwon, Hyukil,Kim, SangWoo,Kabir, K M Ahsan,Li, Xiaojie,Kim, Oksu,Lee, YoungJoon,Kim, SeoYune,Kim, OkJoon Baillière Tindall ; Springer London 2012 LASERS IN MEDICAL SCIENCE Vol.27 No.2
<P>Human gingival fibroblasts (hGFs) play an important role in the inflammatory reaction to lipopolysaccharide (LPS) from P. gingivalis, which infects periodontal connective tissue. In addition, although light-emitting diode (LED) irradiation has been reported to have biostimulatory effects, including anti-inflammatory activity, the pathological mechanisms of these effects are unclear. This study examined the effects of 635-nm irradiation of P. gingivalis LPS-treated human gingival fibroblasts on inflammatory cytokine profiles and the mitogen-activated protein kinase (MAPK) pathway, which is involved in cytokine production. Gingival fibroblasts treated or not treated with P. gingivalis LPS were irradiated with 635-nm LED light, and cytokine profiles in the supernatant were assessed using a human inflammation antibody array. Expression of cyclooxyginase-2 (COX-2) protein and phosphorylation of extracellular signal-regulated kinase (ERK 1/2), p38, and c-Jun-N-terminal kinase (JNK) were assessed by Western-blot analysis to determine the effects on the MAPK pathway, and prostaglandin E(2) (PGE(2)) in the supernatant was measured using an enzyme-linked immunoassay. COX-2 protein expression and PGE(2) production were significantly increased in the LPS-treated group and decreased by LED irradiation. LPS treatment of gingival fibroblasts led to the increased release of the pro-inflammatory-related cytokines interleukin-6 (IL-6) and IL-8, whereas LED irradiation inhibited their release. Analysis of MAPK signal transduction revealed a considerable decrease in p38 phosphorylation in response to 635-nm radiation either in the presence or absence of LPS. In addition, 635-nm LED irradiation significantly promoted JNK phosphorylation in the presence of LPS. LED irradiation can inhibit activation of pro-inflammatory cytokines, mediate the MAPK signaling pathway, and may be clinically useful as an anti-inflammatory tool.</P>
Kim, Youngjoon,Lee, Byeongho,So, Hyoungmin,Kim, Seong-Cheol IEEE 2018 IEEE SENSORS JOURNAL Vol.18 No.3
<P>This paper proposes a distributed localization algorithm in wireless sensor networks. The algorithm considers the position uncertainty of reference nodes, which have been ignored in the past research, in which imperfect position information of reference nodes intensifies the error accumulation phenomenon. The algorithm calculates position uncertainty by the dilution of precision and presents a balance point between range errors and position errors by applying the modified spring mass method. We verify the feasibility of the proposed algorithm by changing multiple parameters under various circumstances. The result proves that the overall performance of localization is enhanced by considering the position uncertainty.</P>