척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

교정환자의 브라켓과 치아 경계부에 존재하는 치면세균막내 mutans streptococci 종 및 생물형의 식별

김미애,유소영,김화숙,국중기,임성훈,윤영주,김광원 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.1

본 연구는 교정환자의 브라켓과 치아 경계부 및 브라켓으로부터 2 mm 이상 떨어진 치아 평활면의 치면세근막에 존재하는 mutaus streptococci의 종 및 생물형에 차이가 있는지를 알아보고자 시행되었다. 조선대학교 치과병원에 내원한 13세 이상 35세 미만의 환자 28명으로부터 브라켓을 장착하고 있는 61개 치아에서 치균세균막을 채취하여 mutans streptococci를 MSB 배지에서 선택적으로 분리한 다음, 이들의 지놈 DNA를 추출하여 dextranase 유전자를 표적으로 하는 중합효소연쇄반응법을 시행하고, 그 증폭물을 Hae Ⅲ로 소화하고, 이를 전기영동하여 제한효소절편길이에 따라 그 종을 식별하였다. 또한 생물형을 조사하기 위하여 생화학적 검사를 실시하였다. 그 결과 브라켓과 치아 경계부 및 브라켓으로부터 2 mm 이상 떨어진 평활면의 치면세균막에 존재하는 mutans streptococci 종은 서로 비슷한 검출 빈도를 보이나 두 곳에 존재하는 mutans streptococci 생물형은 서로 차이가 있는 것으로 나타났다. 향후 브라켓과 치아 경계부 및 치아 평활면의 치면세균막의 mutans streptococci 생물형의 차이와 브라켓 주위의 법랑질 탈회 및 치아우식증 발병과의 상관관계에 대한 연구가 필요하다. The aim of this study was to compare the species and biotypes of mutans streptococci isolated from dental plaques sampled from the interfaces between the bracket and tooth surface and smooth tooth surfaces in orthodontic patients. Dental plaque was collected from the interfaces between brackets and teeth (test group), and from smooth tooth surfaces distant from brackets by more than 2 mm (control group). The dental plaque collected by a sterilized curette was transferred into a vial of 1 X PBS. The sample in the vial was vigorously vortexed for1 min and plated on mitissalivarius bacitracin (MSB) agar plate using cotton tips. The agar plates were incubated at 37℃ in a candle jar for 2 days, and again incubated for 1 more day at anambient temperature. Individual colonies were cultured in TH broth at 37℃ CO₂ incubator. The PCR-RFLP based on dextranase gene was performed for the identification of mutans streptococci at the species-level. For biotyping of mutans streptococci, biochemical tests were performed. There was no significant difference of the species of mutans streptococci isolated from both test and control groups. However, the biotypes of the mutans streptococci isolated from test and control groups were different. These results may offer the basic data to verify the relationship between the mutans streptococci biotype and enamel decalcification or dental caries in orthodontic patients with fixed appliances.

이종 재료 접합부의 응력확대계수

김문기,국정한,유중학,성호현 韓國技術敎育大學校 1996 論文集 Vol.3 No.1

In this study, fracture aspects for dissimilar materials welded by right and left or up and down in symmetry are examined by using Finite Element Method(FEM) in case that holes exist at up and down in symmetry for the center of crack, and the results of this study are as follows ; 1. When the strength(E₁) of a material with a center crack is lower than that (E₂) of the dissimilar material which is welded by right and left in symmetry, the crack propagation rate decreases by about 25%, while it increases by about 20% when the E₁ is higher than E₂. 2. When the E₁ is lower than the E₂ which is welded by up and down in symmetry, the crack propagation rate decreases by about 25% while it increases by about 75% when the E₁ is higher than the E₂. 3. The value of K₁/K?? is constant up to 2.0 in which is the ratio (a/R) between crack length and hole radius, and the value is decreased or increased a little above 2.0. It is regarded that a phenomenon of crack closure is applied according to the welded type of dissimilar material. In addition, It is noticed that retardation effect of crack propagation is changed greatly according to the distributed position of dissimilar material.

산업장 근로자들의 건강증진 프로그램에 대한 수요

유중선,김석범,강복수 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

산업장 근로자들의 건강과 관련된 변수 및 행태를 조사하고, 그들이 원하는 건강증진 내용을 각 근로자의 특성별로 조사하여 비용-효과적인 근로자 건강 증진 프로그램을 개발하기 위해 1995년 12월부터 1996년 1월 사이에 실시된 40개의 근로자 일반 건강검진 및 특수검진 사업장에 근무하는 근로자 500명을 무작위로 추출하여 검진 실시와 병행하여 이 연구를 위해 개발된 설문지를 이용하여 자기기입식 방법에 의해 자료를 수집하였다. 현재 직장에서 실시하고 있는 건강증진 활동으로는 야외운동이 14.8%로 가장 많았으며, 정기적 건강검진, 실내운동 및 맨손체조 순이었다. 남자에서는 야외운동이 가장 많이 수행하는 건강증진 활동이었으며, 여자에서는 정기적 건강검진이 가장 많았다. 전체적으로 여자에 비해 남자의 건강증진 활동률이 더 높았다. 앞으로 현재근무하는 직장에서 실시되기를 희망하는 건강증진 활동은 정기적 건강검진이 26.2%로 가장 많았으며, 건강상담, 실내운동 및 야외운동 순이었다. 남자에서는 정기적 건강검진이 33.7%로 가장 많았으며, 그 외에도 건강상담, 실내운동, 야외운동 순으로 희망하였다. 여자에서는 체중관리 프로그램이 21.4%로 가장 많았고, 정기적 건강검진, 건강상담 등의 순이었다. 근무부서별 희망 건강증진 활동은 생산직의 경우 남녀근로자 모두 정기적 건강검진을 가장 선호하였고, 사무직의 경우 남자는 정기적 건강검진을, 여자는 체중관리 프로그램을 가장 많이 희망하였다. BMI 지수별 희망 건강증진 활동은 저체중 근로자 중 남자는 영양교육을, 여자는 체중관리 프로그램을 가장 선호하였다. 정상체중에 속하는 여자 근로자들도 체중관리 프로그램을 가장 선호하였다. 규칙적인 운동 및 식사를 하는 근로자는 남녀 모두 정기적 건강검진을 가장 선호하였으며, 규칙적인 운동 및 식사를 하지 않는 근로자 중 여자는 체중관리 프로그램을 가장 선호하였다. 남자 근로자는 음주 및 흡연 여부에 관계없이 정기적 건강검진, 건강상담 및 실내운동 순으로 선호하였다. 이상의 결과로 앞으로 가장 우선적으로 실시해야 할 건강증진프로그램은 정기적 건강검진이며 현대 실시중인 근로자 정기신체검사에 대한 만족도가 낮아 검진의 내용과 방법에 대한 개선이 요구되며 여성근로자들에 대한 체중 및 영양에 대한 올바른 지식 및 태도를 갖도록 하는 교육프로그램과 흡연근로자들을 대상으로 하는 금연프로그램의 필요성을 고취시켜야 하겠다. This study was conducted to identify the demand of work-site health promotion program of employees. A self-administered questionnaire method was used to collect data from 492 employees from 40 work-sites in Taegu City and Kyungpook Provincial area. The work-site health screening programs conducted for several years were placed low value by employees. The out-door exercise was the most popular health promotion activity implemented at work-site as a whole. The employees expressed that periodic health check-up, the health counseling, indoor exercise would be implemented as a health promotion program in the future. The male employees regarded that the periodic health check-up program should be established preferentially at work-site. However, the female employees gave priority to fitness program. The health related behavioral patterns slightly influenced the preference of health promotion program. The health screening program for employees should be improved and the health education of nutrition and diet for female employees should be implemented.

제 2형 당뇨병 환자에서 혈중 Metalliproteinase-9의 농도

김상용,김희중,주유철,최동현,배학연 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Purpose : Diabetic nephropathy is a serious complication of diabetes and accounts for much of its morbidity and mortality. It is well known that the overt clinical phase of diabetic nephropathy is preceded for many years by the presence of microalbuminuria. Microalbuminuria is thought to be a marker of widespread vascular damage and may underlie the propensity toward severe extrarenal vascular disease in microalbuminuric patients. Metalloproteinase-9 has a broad substrate specificity for native collagens as well as proteoglycan and elastin. One study reported that an increased plasma metalloproteinase-9 concentration precedes the development of microalbuminuria in type 2 diabetic patients. Another study reported that a high glucose concentration cause a abnormality on the activity of metalloproteinase by the mesangeal cell. The purpose of the present study was to examine whether palsma metalloproteinase-9 concentrations are altered at various complications in type 2 diabetic patients. Methods : Sixty patients with type 2 diabetes and thirty healthy control were recruited for the present study. No patient had any malignancy or history of heart disease, liver disease, collagen disease. We recorded age, duration of diabetes, and blood pressure. After an overnight fast, blood was drawn from an antecubita1 vein of measurement of glucose, metalloproteinase-9, HbA1C, and serum creatinine. To measure plasma concentration of metalloproteinase-9, a one step sandwich enzyme immunoassay using two monoclonal antibodies was used. Patients were divided into two group according to the presence or abscence of microalbuminuria. The groups were then compared with regard to clinical and laboratory characteristics and serum concentration of metalloproteinase-9. Results : The mean serum levels of metalloproteinase-9 in diabetic patients (62.32±25.83ng/㎖) were significantly higher than in healthy controls(12.92±4.97ng/㎖) (p<01). The mean serum levels of metalloproteinase-9 in diabetic patients with microalbuminuria(81.16±41.43ng/㎖) were significantly higher than in those with normoalbuminuria(31.48±7.34ng/㎖) (p<01) and much more than in healthy control(12.92±4.97ng/㎖) (p<05). Furthermore, the severity of nephropathy were closely associated with the serum metalloproteinase-9 level and the serum metalloproteinase-9 level was significantly correlated with microalbuminuria. The mean serum level of metalloproteinase-9 in diabetic patients with retinopathy(61.74±39.07ng/㎖) was significantly higher than in those with no retinopathy(34.98±9.02ng/㎖) (p<05). But, in diabetic patients with normoalbuminuria, there is no difference between the groups with retinopathy versus no retinopathy. Conclusion : In summary, a sustained increase in serum metalloproteinase-9 in patients with type 2 diabetes is associated with a high risk for the development of microalbuminuria. The results of this study suggest that the serum rnetalloproteinase-9 was a useful and noninvasive marker for the development of diabetic nephropathy. It could be also used to predict the development of diabetic complications and to assess therapeutics or the prognosis of diabetes. The usefulness of this model will be clarified by a larger scale and serial study.

내측두엽 간질에서 위스콘신카드 분류검사

김철호,이상암,유희정,강중구,이정교 대한간질학회 2003 대한간질학회지 Vol.7 No.1

TiAIN 코팅 평 엔드밀의 성능평가에 관한 기초 연구

유중학,국정한,김문기 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.5

The purpose of this study is an evaluation of flat end mills to develop appropriate tools for the high speed machining. First of all, several flat end mills which are produced by different markers are selected to analyze the performances of the tools. Experimental works are also executed to measure cutting force, tool wear and surface roughness for different cutting conditions. And then the results are compared and analyzed for developing optimal cutting tool in the high speed condition.

한국·미국·스페인 청소년의 태권도 수련이 인성교육에 미치는 영향

유창재,양정옥,이중숙,이상돈,김영수,조만태 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to analyzed what effect Taekwondo training has upon Juvenile trainees in Korea, America, and Spain. to see if there is a significant difference in their Human nature Education. The subject of this study was set up as 547 Juvenile trainees who are including 183 Koreans, 185 Americans and 179 Spanish people belonging to gymnasia in their own countries, and sampling by purpose sampling. The means in this study is used to amend and complemented after confirming suitability of the contents in the questionnaire that is made on the basis of questionnaire Lee Chul Ho(1996). it is used as study means after modified, whether the substance of question is right in fitness and applicability or not, Reliability of the question, the range of Cronbach's a is showed from .7924 to .8450. The method of statistically analysis adapted one-way ANOVA, two-way ANOVA by using SPSS WIN 10.0 Program. The result of this study are as followed : First, it can be seen that American Juvenile and Spanish Juvenile show more significant change than Korean Juvenile in their Human nature Education by the Taekwondo training according to their nationality. Second, it can be seen that Juvenile who have had the Taekwondo training for more than from three to five year show more significant change in their emotion, sociability and attitude towards life than those who have had the same training for more than other period in their Human nature Education according to their Taekwondo training period. Third, as a result of analytic investigation of what effect the same training has upon the change factors in their Human nature Education in accordance with their training period and nationality, it can be seen that the training itself and nationality has the greater influence on them than the training period. Therefore, judging from the above findings, it can be proved that the Taekwondo training has much more significant and positive effect on Juvenile in their change of emotion, sociability and attitude towards life.

중합효소연쇄반응법을 이용한 급성 치수 및 치근단 질환의 병원성 세균의 동정

김지훈,유소영,임선아,국중기,임상수,박슬희,황호길 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.2

The purpose of this study was to investigate the frequency of 7 putative pathogens in endodontic infections. The specimens were collected from infected pulpal tissue of patients who were referred for root canal treatment to the department of conservative dentisty, Chosun University. Samples were collected aseptically using a barbed broach and a paper point. The cut barbed broaches and paper points were transferred to an eppendorf tube containing 500 ml of 1 X PBS. DNAs were extracted from the samples by direct DNA extraction method using lysis buffer (0.5% EDTA, 1% Triton X-100). Identification of 7 putative pathogens was performed by PCR based on 16S rDNA. The target species were as follows: Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Actinobacillus actinomycetemcomitans, and Treponema denticola. Our data revealed that the prevalence of P.endodontalis was found in 88.6% (39 / 54), P.gingivalis 52.3% (23 / 44), P.nigrescens 18.2%(8 / 44), P.intermedia 15.9% (7 / 44), B.forsythus 18.2% (8 / 44), A.actinomycetemcomitans 2.3% (1 / 44), T.denticola 25% (11 / 44) of the samples. The high prevalence of P. endodontalis and P.gingivalis suggests that they may play an important role in the etiology of endodontic infections.

打擊速度 및 溫度變化가 豫크랙을 가진 衝擊試驗片의 動的破壞靭性에 미치는 影響

兪在煥,李敬奉,金重吉,李致雨,吳世旭 慶南大學校 附設 工業技術硏究所 1989 硏究論文集 Vol.7 No.-

計裝化衝擊試驗에서 打擊速度와 溫度의 變化가 豫크랙을 揷入한 衝擊試驗片의 動的破壞靭性에 미치는 影響을 考察한 結果 다음을 알 수 있었다. 豫크랙을 揷入한 試驗片이 V-노치 試驗片에 比하여 實驗値의 分散度가 적으며 0℃以下의 溫度領域에서 動的破壞靭性의 有效性이 있었다. 또한 打擊速度와 實驗溫度의 影響은 溫度가 速度보다 훨씬 上廻하는 傾向이었다. The effect of various impact velocity and temperature on dynamic fracture toughness is tested with precracked Charpy specimen, and conclude following results. Precracked specimen has less dispersion of test results than V-notched specimen, unstable crack initiation load didn't agreed to maximum load at room temperature but at 0℃ below, thus, the availability of dynamic fracture toughness is relatively high. Comparing V-notched specimen, the precracked Charpy specimen represented lower shelf of temperature different. But, at this time, the absorbed energy is estimated equivalently. With the decrease of temperature, the reduction of fracture toughness was obvious, but the effect of impact velocity didn't appear.