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Kim, Yeon Joo,Kim, Jong Hoon,Yu, Chang Sik,Kim, Tae Won,Jang, Se Jin,Choi, Eun Kyung,Kim, Jin Cheon,Choi, Wonsik The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: The concentration of capecitabine peaks at 1-2 hours after administration. We therefore assumed that proper timing of capecitabine administration and radiotherapy would maximize radiosensitization and influence survival among patients with locally advanced rectal cancer. Materials and Methods: We retrospectively reviewed 223 patients with locally advanced rectal cancer who underwent preoperative chemoradiation, followed by surgery from January 2002 to May 2006. All patients underwent pelvic radiotherapy (50 Gy/25 fractions) and received capecitabine twice daily at 12-hour intervals ($1,650mg/m^2/day$). Patients were divided into two groups according to the time interval between capecitabine intake and radiotherapy. Patients who took capecitabine 1 hour before radiotherapy were classified as Group A (n = 109); all others were classified as Group B (n = 114). Results: The median follow-up period was 72 months (range, 7 to 149 months). Although Group A had a significantly higher rate of good responses (44% vs. 25%; p = 0.005), the 5-year local recurrence-free survival rates of 93% in Group A and 97% in Group B did not differ significantly (p = 0.519). The 5-year disease-free survival and overall survival rates were also comparable between the groups. Conclusions: Despite the better pathological response in Group A, the time interval between capecitabine and radiotherapy administration did not have a significant effect on survivals. Further evaluations are needed to clarify the interaction of these treatment modalities.
Imaging the Completely Buried Anomaly using a Small-ship Three-dimensional Seismic Survey System
Kim, Wonsik,Shin, Jungkyun,Kim, Hyundo,Yi, Bo-Yeon,Park, Chanho,Kim, Chansu,Seo, Gabseok,Cho, Dongwoo,Jung, Yonghwa,Lee, Ho-Young,Kang, Dong-Hyo BioOne (Coastal Education and Research Foundation) 2018 JOURNAL OF COASTAL RESEARCH Vol.85 No.special
KoFlux: A New Tool to Study the Biosphere-Atmosphere Interactions in Asia
Joon Kim,Wonsik Kim,Byong-lyol Lee,Ki-hyun Kim,Kyu-rang Kim,Min-young Kim,Bang-yong Lee,Do-won Lee,Gang-woong Lee,Jeong-taek Lee,Jong-hwan Lim,Jai-ho Oh,Eun-woo Park,Jae-seol Shim,Jin-il Yun,Chae-shik 한국기상학회 2002 대기 Vol.12 No.1
Light-induced electrical switch <i>via</i> photo-responsive nanocomposite film
Lee, Wonsik,Kim, Dongjun,Lim, Joonyoung,Kim, Geonho,Kim, Ikyon,Kim, Songkuk,Kim, Jiwon Elsevier 2018 Sensors and actuators. B Chemical Vol.266 No.-
<P><B>Abstract</B></P> <P>Photo-responsive nanomaterials have attracted a lot of attention since they allow a remote control with a non-invasive stimulus—light. Owing to this property, it has been applied to next-generation electrical devices, which are desired to be flexible and transparent for a wider range of applications. Herein, we developed a flexible, transparent and conductive film which can change its shape <I>via</I> light of specific wavelength to control the electrical conductivity between electrodes. The film is composed of three layers: azobenzene incorporated poly(dimethylsiloxane), AzoPDMS; silk fibroin; and silver nanowires, AgNWs. When azobenzene within the polymer changes its molecular arrangement upon irradiation, the difference in volume changes of AzoPDMS and silk fibroin layer results in the film to bend. Since a silk fibroin layer folds inward upon irradiation, AgNWs are coated onto the silk fibroin layer to be selectively in contact with the electrodes. This photo-responsive nanocomposite film is flexible, transparent and conductive which can be connected to the circuit on demand <I>via</I> light acting as an electrical switch. We believe it can be combined with various transparent electronic devices to further expand its applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A flexible, transparent and conductive photo-bending film was fabricated. </LI> <LI> The photo-responsive film consists of photo-responsive/support/conductive layers. </LI> <LI> The film could bend up to 90° with switching time of a few seconds upon irradiation. </LI> <LI> The conductivity of film can be optimized by changing the concentration of silver nanowires. </LI> <LI> The film can be connected to the circuit on demand acting as a light-induced electrical switch. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yeon Joo Kim,Jong Hoon Kim,Chang Sik Yu,Tae Won Kim,Se Jin Jang,Eun Kyung Choi,Jin Cheon Kim,Wonsik Choi 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: The concentration of capecitabine peaks at 1–2 hours after administration. We therefore assumed that proper timing of capecitabine administration and radiotherapy would maximize radiosensitization and influence survival among patients with locally advanced rectal cancer. Materials and Methods: We retrospectively reviewed 223 patients with locally advanced rectal cancer who underwent preoperative chemoradiation, followed by surgery from January 2002 to May 2006. All patients underwent pelvic radiotherapy (50 Gy/25 fractions) and received capecitabine twice daily at 12-hour intervals (1,650 mg/m 2 /day). Patients were divided into two groups according to the time interval between capecitabine intake and radiotherapy. Patients who took capecitabine 1 hour before radiotherapy were classified as Group A (n = 109); all others were classified as Group B (n = 114). Results: The median follow-up period was 72 months (range, 7 to 149 months). Although Group A had a significantly higher rate of good responses (44% vs. 25%; p = 0.005), the 5-year local recurrence-free survival rates of 93% in Group A and 97% in Group B did not differ significantly (p = 0.519). The 5-year disease-free survival and overall survival rates were also comparable between the groups. Conclusions: Despite the better pathological response in Group A, the time interval between capecitabine and radiotherapy administration did not have a significant effect on survivals. Further evaluations are needed to clarify the interaction of these treatment modalities.
Kim, Yeon Joo,Song, Si Yeol,Jeong, Seong-Yun,Kim, Sang We,Lee, Jung-Shin,Kim, Su Ssan,Choi, Wonsik,Choi, Eun Kyung The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: To determine failure patterns and survival outcomes of T4N0-1 non-small cell lung cancer (NSCLC) treated with definitive radiotherapy. Materials and Methods: Ninety-five patients with T4N0-1 NSCLC who received definitive radiotherapy with or without chemotherapy from May 2003 to October 2014 were retrospectively reviewed. The standard radiotherapy scheme was 66 Gy in 30 fractions. The main concurrent chemotherapy regimen was $50mg/m^2$ weekly paclitaxel combined with $20mg/m^2$ cisplatin or AUC 2 carboplatin. The primary outcome was overall survival (OS). Secondary outcomes were failure patterns and toxicities. Results: The median age was 64 years (range, 34 to 90 years). Eighty-eight percent of patients (n = 84) had an Eastern Cooperative Oncology Group performance status of 0-1, and 42% (n = 40) experienced pretreatment weight loss. Sixty percent of patients (n = 57) had no metastatic regional lymph nodes. The median radiation dose was EQD2 67.1 Gy (range, 56.9 to 83.3 Gy). Seventy-one patients (75%) were treated with concurrent chemotherapy; of these, 13 were also administered neoadjuvant chemotherapy. At a median follow-up of 21 months (range, 1 to 102 months), 3-year OS was 44%. The 3-year cumulative incidences of local recurrence and distant recurrence were 48.8% and 36.3%, respectively. Pretreatment weight loss and combined chemotherapy were significant factors for OS. Acute esophagitis over grade 3 occurred in three patients and grade 3 chronic esophagitis occurred in one patient. There was no grade 3-4 radiation pneumonitis. Conclusion: Definitive radiotherapy for T4N0-1 NSCLC results in favorable survival with acceptable toxicity rates. Local recurrence is the major recurrence pattern. Intensity modulated radiotherapy and radio-sensitizing agents would be needed to improve local tumor control.
Neural correlates of bridging inferences and coherence processing.
Kim, Sung-il,Yoon, Misun,Kim, Wonsik,Lee, Sunyoung,Kang, Eunjoo Plenum Press 2012 JOURNAL OF PSYCHOLINGUISTIC RESEARCH Vol.41 No.4
<P>We explored the neural correlates of bridging inferences and coherence processing during story comprehension using Positron Emission Tomography (PET). Ten healthy right-handed volunteers were visually presented three types of stories (Strong Coherence, Weak Coherence, and Control) consisted of three sentences. The causal connectedness among sentences in the Strong Coherence story was strong that readers would not have to generate bridging inferences, whereas the causal antecedent of the last sentence in the Weak Coherence story was not explicitly stated so that readers should draw bridging inferences to fill the gap between sentences. It was found that the left middle temporal gyrus was activated while participants read the Weak Coherence stories. In contrast, the dorsomedial prefrontal cortex (dmPFC) and posterior cingulate cortex were activated only in the Strong Coherence condition. This suggests that the dmPFC was involved in coherence processing whereas bridging inference was mediated by the left middle temporal gyrus. It was also found that anterior temporal pole and the temporo-parietal junction mediated general semantic processing.</P>
Kim, Hoijoon,Park, Taejin,Park, Seongjae,Leem, Mirine,Ahn, Wonsik,Lee, Hyangsook,Lee, Changmin,Lee, Eunha,Jeong, Seong-Jun,Park, Seongjun,Kim, Yunseok,Kim, Hyoungsub Elsevier 2019 THIN SOLID FILMS - Vol.673 No.-
<P><B>Abstract</B></P> <P>For the fabrication of high-performance top-gated MoS<SUB>2</SUB> transistors, a uniform atomic layer deposition (ALD) of an ultrathin high-<I>k</I> gate dielectric film without abnormal leakage paths on a MoS<SUB>2</SUB> channel is required. In this study, we fabricated a ~5.2 nm-thick monolithic HfO<SUB>2</SUB> gate dielectric film by utilizing an e-beam-evaporated Hf seed layer (target thickness of 3 nm) prior to the ALD of a HfO<SUB>2</SUB> film (~2 nm). The Hf seed layer was fully converted to HfO<SUB>2</SUB> without metallic residues during the following ALD process, without damages to the Raman and photoluminescence characteristics of the underlying MoS<SUB>2</SUB>. The conformal and pinhole-free ALD of the subsequent HfO<SUB>2</SUB> film was verified using conductive atomic force microscopy. In addition, operation of a top-gated MoS<SUB>2</SUB> transistor was demonstrated by integrating the Hf-seeded HfO<SUB>2</SUB> gate dielectric film.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Conformal and monolithic Hf-seeded ALD-HfO<SUB>2</SUB> film is formed on MoS<SUB>2</SUB>. </LI> <LI> Hf seed layer formation does not impose significant damages on MoS<SUB>2</SUB>. </LI> <LI> Hf-seeded HfO<SUB>2</SUB> gate dielectric film can be integrated in top-gated MoS<SUB>2</SUB> transistor. </LI> </UL> </P>
Wonsik Kim,Seungsun Choi,Woojin Shin,Jaewon Oh,Mee-Yi Ryu,Hyunbok Lee 한국진공학회(ASCT) 2021 Applied Science and Convergence Technology Vol.30 No.1
Ultraviolet-ozone (UVO) treatment modifies the surface properties of film for use in thin-film optoelectronics. In particular, the hydrophobic nature of the surface of organic films can be changed to a hydrophilic nature, thereby enabling a multilayer structure using a solution process. However, the electronic structure of organic films with UVO treatment has not been investigated in detail. In this study, the changes in the electronic structure of tetra-tert-butyl copper phthalocyanine (ttb-CuPc) films by UVO treatment were explored using UV-vis absorption spectroscopy and X-ray photoelectron spectroscopy (XPS). The ttb-CuPc film was fabricated by spin coating, and various UVO treatment times were applied. As the UVO treatment time increased, the absorption intensity of the ttb-CuPc films exponentially decayed. In the XPS spectra, the oxidation process was observed in two stages (macrocyclic isoindole units followed by peripheral ttb units). Upon oxidation, while the C and N atoms in the ligands exhibited an electron-donating characteristic, the central Cu atom showed an electron-withdrawing nature. Such an altered charge distribution on the ttb-CuPc molecule can significantly influence charge transport in optoelectronic devices.