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Kim, Taesoo,Kim, Kabsun,Lee, Seoung Hoon,So, Hong-Seob,Lee, Junwon,Kim, Nacksung,Choi, Yongwon American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.22
<P>Osteoblasts are the primary cells responsible for bone formation. They also support osteoclast formation from bone marrow precursors in response to osteotropic factors by inducing receptor activator of NF-kappaB ligand (RANKL) expression and down-regulating osteoprotegerin (OPG) production. In addition to the RANKL-RANK-OPG signaling axis, other factors produced by osteoblasts/stromal cells are involved in osteoclastogenesis. Here, we describe the identification and characterization of leucine-rich repeat-containing 17 (LRRc17), a member of the LRR superfamily that acts as a negative regulator of RANKL-induced osteoclast differentiation. Osteoblasts showed high levels of LRRc17 expression, which was down-regulated in response to the pro-osteoclastogenic factor 1,25-dihydroxyvitamin D(3). Recombinant LRRc17 protein inhibited RANKL-induced osteoclast differentiation from bone marrow precursors, whereas it did not affect the differentiation or activation of macrophages and dendritic cells. These results suggest that among the cell types derived from common myeloid precursors, LRRc17 specifically regulates osteoclasts. Further analysis revealed that LRRc17 attenuated RANKL-induced expression of NFATc1 by blocking phospholipase C-gamma signaling, which, in turn, inhibited RANKL-mediated osteoclast differentiation. Taken together, our results demonstrated a novel inhibitory activity of LRRc17 in RANKL-induced osteoclastogenesis.</P>
Kim, TaeSoo,Cho, YongHyun BUTTERWORTH - HEINEMANN 2014 MATERIALS AND DESIGN Vol.58 No.-
Aluminum alloys have been utilized in various industrial fields and building structures due to high strength-to-weight ratio, increased durability, formability and enhanced service life. They can be classified into seven groups from 1000 to 7000 series according to alloyed chemical compositions except main pure aluminum component. Experiments of single-lap joints with 6061 type alloys were performed by Kim et al. and the results show that curling (out-of-plane deformation toward plate thickness direction) occurred in bolted joints with a long end distance and it is found that the curling influenced mechanical strength. In this paper, ultimate strength and failure mechanism of single shear sheet bolted joints fabricated with two different aluminum alloys; 6061-T6 (aluminum-magnesium-silicon series) and 7075-T6 (aluminum-zinc-magnesium-copper series), which are the most widely used materials due to the need of high strength were compared. Alloy type, plate thickness, end distance and bolt arrangement were considered as main variables. Monotonic tensile tests have been conducted for specimens and two fracture modes such as shear fracture and block shear fracture were observed. Some bolted joints with relatively thinner plate and longer end distance were accompanied by curling and the curling led to sudden strength reduction. The difference of material properties and plate thickness affected failure mechanism and curling occurrence. Moreover, strain distribution and curling deformation pattern against enforced displacement were investigated to grasp the curling effect on the behaviors of joints. (C) 2014 Elsevier Ltd. All rights reserved.
Full-Body Animation of Human Locomotion in Reduced Gravity Using Physics-Based Control
Kim, Yun-hyeong,Kwon, Taesoo,Song, Daeun,Kim, Young J. IEEE 2017 IEEE computer graphics and applications Vol.37 No.6
<P>The proposed physics-based approach can generate stable and robust full-body animation of various gaits under different gravitational conditions. As input, this method takes motion-captured human motions in the Earth’s gravity and builds an inverted-pendulum on cart (IPC) control model, which is analyzed using the motion-captured data. The authors use a pre-estimation model based on the Froude number to predict the desired velocity and stride frequency of a character model in hypogravity and then generate full-body animation using a pendulum trajectory generator, motion planner, and tracking.</P>
Kim Taesoo,Jo Kyubong 한국바이오칩학회 2023 BioChip Journal Vol.17 No.3
Microfl uidics is fl ourishing due to its signifi cant applications in life sciences and biomedical engineering. One of the key challenges in microfl uidics is the manipulation and control of fl uids within microscale channels. Capillary force-driven fl ows provide a potential solution to this challenge by eliminating the need for an external power source. Capillary force- driven fl ows are particularly useful for the reproducible and reliable quantitative analysis of single-molecule DNA. We have designed several microfl uidic devices that employ capillary force to enhance the deposition of DNA molecules onto a positively charged glass surface from a sample solution. The optimization of specifi c dimensions within the microfl uidic device resulted in increased effi ciency of DNA deposition. Shortening the microchannel length reduced fl ow resistance and decreasing the microchannel height enhanced capillary force. Additionally, increasing the outlet reservoir capacity achieves mechanical equilibrium in situations where fl uid fl ow is maximized. These optimizations served to maximize capillary force and improve DNA deposition on the glass surface. The developed device represents an ultra-sensitive platform for quantitative DNA analysis and rapid, accurate point-of-care testing with a minimum detection limit achieved. In conclusion, our work demonstrates the potential of capillary force-driven microfl uidics for the reproducible and effi cient manipulation of fl uids within microscale channels.
SGX-Tor: A Secure and Practical Tor Anonymity Network With SGX Enclaves
Kim, Seongmin,Han, Juhyeng,Ha, Jaehyeong,Kim, Taesoo,Han, Dongsu Institute of Electrical and Electronics Engineers, 2018 IEEE/ACM transactions on networking Vol.26 No.5
<P>With Tor being a popular anonymity network, many attacks have been proposed to break its anonymity or leak information of a private communication on Tor. However, guaranteeing complete privacy in the face of an adversary on Tor is especially difficult, because Tor relays are under complete control of world-wide volunteers. Currently, one can gain private information, such as circuit identifiers and hidden service identifiers, by running Tor relays and can even modify their behaviors with malicious intent. This paper presents a practical approach to effectively enhancing the security and privacy of Tor by utilizing Intel SGX, a commodity trusted execution environment. We present a design and implementation of Tor, called SGX-Tor, that prevents code modification and limits the information exposed to untrusted parties. We demonstrate that our approach is practical and effectively reduces the power of an adversary to a traditional network-level adversary. Finally, SGX-Tor incurs moderate performance overhead; the end-to-end latency and throughput overheads for HTTP connections are 3.9% and 11.9%, respectively.</P>