랜덤화 블록 계획법에서 위치를 이용한 비모수 검정법

심수진,김동재,Sim, Sujin,Kim, Dongjae 한국데이터정보과학회 2013 한국데이터정보과학회지 Vol.24 No.6

반복이 있는 랜덤화 블록 계획법에서 우산형 대립가설을 검정하기 위한 비모수 방법에는 Kim과 Kim (1992)이 제안한 방법이 있다. 본 논문에서는 Orban과 Wolfe (1982)가 제안한 위치와 Kim (1999)이 제안한 대조군과 처리군의 방법을 확장하여 랜덤화 블록 계획법에서 우산형 대립가설에서의 검정법을 제안하였다. 또한 여러 분포에 대한 모의실험 통하여 기존의 방법과의 검정력을 비교하였다. Kim and Kim (1992) proposed typical nonparametric method for umbrella alternative in randomized block design with replications. In this paper, We consider a test procedure for umbrella alternatives in a randomized block design using extension of the two sample placement tests described in Orban and Wolfe (1982) and treatment tests described in Kim (1999). We perform a Monte Carlo study to compare the empirical powers of the test statistics for underlying distributions.

한국어교육에서 다중언어능력 및 다중문화능력의 개념과 적용

조수진 ( Cho¸ Sujin ),김태나 ( Kim¸ Taena ),강승혜 ( Kang¸ Seunghae ) 한국언어문화교육학회 2021 언어와 문화 Vol.17 No.3

This study examines the concept of plurilingual and pluricultural competence presented by the CEFR(2018) and proposes application methods in Korean language education. In Korean language education, learners can improve their competence to target language and culture by understanding that learners have various languages and cultural backgrounds and utilizing such resources and experiences. To this end, the understanding and acceptance of culture can be facilitated by establishing a pluricultural repertoire. The target language can be learned by utilizing various language resources through plurilingual understanding of plurilingualism. Furthermore, by building a plurilingual repertoire, it is possible to take advantage of the language resources that learners have to take the initiative in language learning. By applying this concept, a teaching-learning method can be proposed so that learners can utilize each other's language and cultural resources in professor learning, which used only Korean, the target language in Korean education. (Sogang UniversityㆍSogang UniversityㆍYonsei University)

Age-dependent gait abnormalities in mice lacking the <i>Rnf170</i> gene linked to human autosomal-dominant sensory ataxia

Kim, Youngsoo,Kim, Seong Hun,Kim, Kook Hwan,Chae, Sujin,Kim, Chanki,Kim, Jeongjin,Shin, Hee-Sup,Lee, Myung-Shik,Kim, Daesoo IRL Press 2015 Human molecular genetics Vol.24 No.25

<P>Really interesting new gene (RING) finger protein 170 (RNF170) is an E3 ubiquitin ligase known to mediate ubiquitination-dependent degradation of type-I inositol 1,4,5-trisphosphate receptors (ITPR1). It has recently been demonstrated that a point mutation of <I>RNF170</I> gene is linked with autosomal-dominant sensory ataxia (ADSA), which is characterized by an age-dependent increase of walking abnormalities, a rare genetic disorder reported in only two families. Although this mutant allele is known to be dominant, the functional identity thereof has not been clearly established. Here, we generated mice lacking <I>Rnf170</I> (<I>Rnf170<SUP>−/−</SUP></I>) to evaluate the effect of its loss of function <I>in vivo</I>. Remarkably, <I>Rnf170<SUP>−/−</SUP></I> mice began to develop gait abnormalities in old age (12 months) in the form of asynchronous stepping between diagonal limb pairs with a fixed step sequence during locomotion, while age-matched wild-type mice showed stable gait patterns using several step sequence repertoires. As reported in ADSA patients, they also showed a reduced sensitivity for proprioception and thermal nociception. Protein blot analysis revealed that the amount of Itpr1 protein was significantly elevated in the cerebellum and spinal cord but intact in the cerebral cortex in <I>Rnf170<SUP>−/−</SUP></I> mice. These results suggest that the loss of <I>Rnf170</I> gene function mediates ADSA-associated phenotypes and this gives insights on the cure of patients with ADSA and other age-dependent walking abnormalities.</P>

Associations of Clozapine Use With Psychosocial Functioning and Quality of Life in Patients With Schizophrenia: A Community-Based Cross-Sectional Study

Sujin Kim,Seoyoung Kim,Ah Young Choe,Euitae Kim 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.10

Objective More attempts have been made recently to improve psychosocial functioning and quality of life in patients with schizophrenia, due to their crucial role in long-term outcomes. Previous studies on the effects of clozapine on psychosocial functioning have been limited in terms of generalizability and application to clinical practice. This study examined the relationship of clozapine use with psychosocial functioning and quality of life in patients with schizophrenia in a real-world setting. Methods Data were obtained from a survey targeting community-dwelling patients with schizophrenia. The Behavior and Symptom Identification Scale (BASIS) and Satisfaction with Life Scale (SWLS) were administered to evaluate psychosocial functioning and quality of life, and patients were classified into Clozapine and Non-clozapine groups. Group differences were assessed using ANCOVA, with additional sensitivity analyses for participants on atypical antipsychotic medications only. Results Of 292 patients, the Clozapine group (n=34) had significantly better psychosocial functioning and quality of life than the Nonclozapine group (n=258), as demonstrated by their low BASIS score (F=4.651, df=1, 290, p=0.032) and high SWLS score (F=14.637, df=1, 290, p<0.001). Similar findings for psychosocial outcomes were observed in the analyses of the atypical antipsychotic subgroup (n=195). Conclusion For optimal recovery in schizophrenia, restoration of impaired social functioning and enhanced satisfaction with life are essential. In this study, clozapine use was related to high levels of psychosocial functioning and quality of life in real-world settings. Further research on the causal relationship between clozapine use and psychosocial functioning is needed.

Synthesis and electroluminescent properties of <i>tert</i>-butylated arylamine substituted 9,10-diphenylanthracene derivatives for organic light-emitting diodes

Kim, Dong Young,Kim, Young Seok,Kim, Se Hyun,Jeong, Sujin,Lee, Song Eun,Kim, Young Kwan,Yoon, Seung Soo Elsevier 2016 Synthetic metals Vol.220 No.-

<P><B>Abstract</B></P> <P>This paper reports synthesis and electroluminescent properties of the <I>tert</I>-butylated arylamine-substituted 9,10-diphenylanthracene derivatives for organic light-emitting diodes. The devices using these materials were fabricated in the following sequence: indium-tin-oxide/<I>N</I>,<I>N'</I>-di(1-naphthyl)-<I>N</I>,<I>N'</I>-diphenyl-(1,1′-biphenyl)-4,4′-diamine/emitting material/bathophenanthroline/lithium quinolate/aluminum. All devices showed the efficient electroluminescence depending on the photoluminescent properties of emitters. In particular, a device using 2-<I>tert</I>-butyl-9-(9,10-diphenylanthracen-2-yl)-9<I>H</I>-carbazole exhibited blue emission with the maximum luminance, luminous efficiency, power efficiency and external quantum efficiency of 2552cd/m<SUP>2</SUP>, 2.14cd/A, 1.17lm/W and 2.04% at 20mA/cm<SUP>2</SUP>, respectively, and Commission Internationale d′Éclairage (CIE) coordinates of (0.15, 0.12) at 6.0V. These results suggest that the degree of self-aggregation of the emitters and charge-balances in the emitting layers of devices would be important roles in electroluminescent properties of devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We synthesized the fluorescent materials based on arylamine substituted anthracene. </LI> <LI> These materials showed efficient blue and greenish-blue electroluminescence. </LI> <LI> These materials have appropriate potentials for applications in fluorescent OLEDs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Prenatal exposure to persistent organic pollutants and methylation of LINE-1 and imprinted genes in placenta: A CHECK cohort study

Kim, Sujin,Cho, Yoon Hee,Lee, Inae,Kim, Wonji,Won, Sungho,Ku, Ja-Lok,Moon, Hyo-Bang,Park, Jeongim,Kim, Sungkyoon,Choi, Gyuyeon,Choi, Kyungho Elsevier 2018 Environment international Vol.119 No.-

<P><B>Abstract</B></P> <P>Prenatal exposure to persistent organic pollutants (POPs) has been linked to numerous adverse birth outcomes among newborn infants in many epidemiological studies. Although epigenetic modifications have been suggested as possible explanations for those associations, studies have rarely reported a relationship between POP exposure during pregnancy and DNA methylation in the placenta.</P> <P>In the present study, we investigated the association between prenatal exposure to several POPs, including organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), and methylation levels of long interspersed element 1 (LINE-1), as well as imprinted genes in placental DNAs among Korean mother-child pairs (N = 109). We assessed the association of DNA methylation not only with each target POP (single-POP models) but also with multiple POPs applying principal component analysis (multiple-POP models). Potential associations between placental DNA methylation and birth outcomes of newborn infants were also estimated.</P> <P>In single-POP models, significant associations were detected between OCP measurements and placental DNA methylation. Elevated concentrations of β-hexachlorhexane (β-HCH) in maternal serum collected during delivery were significantly associated with a decrease in methylation of LINE-1 in the placenta. Higher levels of <I>p</I>,<I>p</I>′-dichlorodiphenyltrichloroethane (<I>p</I>,<I>p</I>′-DDT) in maternal serum were associated with hypermethylation of <I>insulin-like growth factor 2</I> (<I>IGF2</I>). In multiple-POP models, a significant and positive association between DDTs and <I>IGF2</I> methylation was also observed. Placental LINE-1 methylation was inversely associated with birth length. Our observations indicate that prenatal exposure to several POPs including DDTs is associated with the changes in methylation of genes, including major imprinted genes in the placenta. The consequences of these epigenetic alterations in placenta during development deserve further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Associations between POP exposure and placental DNA methylation were evaluated. </LI> <LI> A multi-pollutant exposure was added in the models with principal component analysis. </LI> <LI> Exposure to DDTs, including <I>p</I>,<I>p</I>′-DDT, was related to methylation of <I>IGF2</I> in the placenta. </LI> <LI> Several POPs might affect epigenetic regulation of key placental DNAs. </LI> </UL> </P>

Associations of Polyp Characteristics in Children and Adolescents Presenting with Less Than Five Colorectal Polyps: A Full Colonoscopy Is Still Required

Kim Ju Young,Kim Yu Bin,Choi Sujin,Lee Yoo Min,Kim Hyun Jin,Kim Soon Chul,Jang Hyo-Jeong,Choi So Yoon,Yi Dae Yong,Lee Yoon,Choi You Jin,Kang Yunkoo,Lee Kyung Jae,Suk Jin Hong,Hwang Jun Hyun,Kwak Sangg 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.3

Background/Aims: A full colonoscopy is currently required in children and adolescents with colorectal polyps, because of their potential of neoplastic transformation and complications such as intussusception. We aimed to analyze the associations of polyp characteristics in children and adolescents with colorectal polyps. Based on these findings, we also aimed to reevaluate the necessity of conducting a full colonoscopy. Methods: Pediatric patients <18 years of age who had undergone a colonoscopic polypectomy and those with <5 colorectal polyps were included in this multicenter, retrospective study. Baseline clinicodemographics, colonoscopic and histologic findings were investigated. Results: A total of 91 patients were included. Multivariate logistic regression analysis showed that polyp size was the only factor associated with the presence of any polyps located proximal to the splenic flexure (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.28 to 4.28; p=0.007). Furthermore, polyp location proximal to the splenic flexure and sessile morphology were associated with the presence of any adenomatous polyp (OR, 8.51; 95% CI, 1.43 to 68.65; p=0.023; OR, 18.41; 95% CI, 3.45 to 173.81; p=0.002, respectively). Conclusions: In children and adolescents presenting with <5 colorectal polyps, polyp size and the presence of any adenomatous polyp were positively associated with polyp location proximal to the splenic flexure. This finding supports the necessity of a full colonoscopic exam in pediatric patients with colorectal polyps for the detection of polyps before the occurrence of complications such as intussusception or neoplastic transformation.

Proteomic analysis for the effects of non-saponin fraction with rich polysaccharide from Korean Red Ginseng on Alzheimer's disease in a mouse model

Sujin Kim,Yunkwon Nam,Min-jeong Kim,Seung-hyun Kwon,Junhyeok Jeon,Soo Jung Shin,Soyoon Park,Sungjae Chang,Hyun Uk Kim,Yong Yook Lee,Hak Su Kim,Minho Moon The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

Background: The most common type of dementia, Alzheimer's disease (AD), is marked by the formation of extracellular amyloid beta (Aβ) plaques. The impairments of axons and synapses appear in the process of Aβ plaques formation, and this damage could cause neurodegeneration. We previously reported that non-saponin fraction with rich polysaccharide (NFP) from Korean Red Ginseng (KRG) showed neuroprotective effects in AD. However, precise molecular mechanism of the therapeutic effects of NFP from KRG in AD still remains elusive. Methods: To investigate the therapeutic mechanisms of NFP from KRG on AD, we conducted proteomic analysis for frontal cortex from vehicle-treated wild-type, vehicle-treated 5XFAD mice, and NFP-treated 5XFAD mice by using nano-LC-ESI-MS/MS. Metabolic network analysis was additionally performed as the effects of NFP appeared to be associated with metabolism according to the proteome analysis. Results: Starting from 5,470 proteins, 2,636 proteins were selected for hierarchical clustering analysis, and finally 111 proteins were further selected for protein-protein interaction network analysis. A series of these analyses revealed that proteins associated with synapse and mitochondria might be linked to the therapeutic mechanism of NFP. Subsequent metabolic network analysis via genome-scale metabolic models that represent the three mouse groups showed that there were significant changes in metabolic fluxes of mitochondrial carnitine shuttle pathway and mitochondrial beta-oxidation of polyunsaturated fatty acids. Conclusion: Our results suggested that the therapeutic effects of NFP on AD were associated with synaptic- and mitochondrial-related pathways, and they provided targets for further rigorous studies on precise understanding of the molecular mechanism of NFP.

Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer’s Disease

Kim, Sujin,Nam, Yunkwon,Jeong, Yu-on,Park, Hyun Ha,Lee, Seong-kyung,Shin, Soo Jung,Jung, Haram,Kim, Byeong-Hyeon,Hong, Sang Bum,Park, Yong Ho,Kim, Jihee,Yu, Jaemin,Yoo, Doo-Han,Park, Sun-Hyun,Jeon, Se MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.16

<P>It is widely known that the degeneration of neural circuits is prominent in the brains of Alzheimer’s disease (AD) patients. The reciprocal connectivity of the medial septum (MS) and hippocampus, which constitutes the septo-hippocampo-septal (SHS) loop, is known to be associated with learning and memory. Despite the importance of the reciprocal projections between the MS and hippocampus in AD, the alteration of bidirectional connectivity between two structures has not yet been investigated at the mesoscale level. In this study, we adopted AD animal model, five familial AD mutations (5XFAD) mice, and anterograde and retrograde tracers, BDA and DiI, respectively, to visualize the pathology-related changes in topographical connectivity of the SHS loop in the 5XFAD brain. By comparing 4.5-month-old and 14-month-old 5XFAD mice, we successfully identified key circuit components of the SHS loop altered in 5XFAD brains. Remarkably, the SHS loop began to degenerate in 4.5-month-old 5XFAD mice before the onset of neuronal loss. The impairment of connectivity between the MS and hippocampus was accelerated in 14-month-old 5XFAD mice. These results demonstrate, for the first time, topographical evidence for the degradation of the interconnection between the MS and hippocampus at the mesoscale level in a mouse model of AD. Our results provide structural and functional insights into the interconnectivity of the MS and hippocampus, which will inform the use and development of various therapeutic approaches that target neural circuits for the treatment of AD.</P>

The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa

Kim, Hyun Jik,Kim, Chang-Hoon,Kim, Min-Ji,Ryu, Ji-Hwan,Seong, Sang Yeop,Kim, Sujin,Lim, Su Jin,Holtzman, Michael J.,Yoon, Joo-Heon American Thoracic Society 2015 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR Vol.53 No.4