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Kim Hee-Hoon,Shim Young-Ri,Choi Sung Eun,Kim Myung-Ho,Lee Giljae,You Hyun Ju,Choi Won-Mook,Keungmo Yang,Ryu Tom,Kim Kyurae,김민정,Woo Chaerin,Chung Katherine Po Sin,Hong Song Hwa,Eun Hyuk Soo,Kim Seok-Hw 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased hepatic influx of lipopolysaccharide (LPS), suggesting the presence of a veiled tolerance mechanism. In addition to LPS, the liver is affected by several gut-derived neurotransmitters through the portal blood, but the effects of catecholamines on KCs have not been clearly explored in alcohol-associated liver disease (ALD). Hence, we investigated the regulatory roles of catecholamine on inflammatory KCs under chronic alcohol exposure. We discovered that catecholamine levels were significantly elevated in the cecum, portal blood, and liver tissues of chronic ethanol-fed mice. Increased catecholamines induced mitochondrial translocation of cytochrome P450 2E1 in perivenous hepatocytes expressing the β2-adrenergic receptor (ADRB2), leading to the enhanced production of growth differentiation factor 15 (GDF15). Subsequently, GDF15 profoundly increased ADRB2 expression in adjacent inflammatory KCs to facilitate catecholamine/ADRB2-mediated apoptosis. Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Genetic ablation of Adrb2 or hepatic Gdf15 robustly decreased the number of apoptotic KCs near perivenous areas, exacerbating alcohol-associated inflammation. Consistently, we found that blood and stool catecholamine levels and perivenous GDF15 expression were increased in patients with early-stage ALD along with an increase in apoptotic KCs. Our findings reveal a novel protective mechanism against ALD, in which the catecholamine/GDF15 axis plays a critical role in KC apoptosis, and identify a unique neuro-metabo-immune axis between the gut and liver that elicits hepatoprotection against alcohol-mediated pathogenic challenges.
김준석 ( Joon Seok Kim ),김용래 ( Yong Rea Kim ),심민섭 ( Min Seob Sim ),조범석 ( Beom Suk Jo ),전찬호 ( Chan Ho Jeon ),안국진 ( Gook Jin An ),이재권 ( Jae Kwon Lee ),안소영 ( Young So An ),강인정 ( In Jung Kang ),남정환 ( Jung Hw 충북대학교 과학교육연구소 2017 과학교육연구논총 Vol.33 No.1
The soybean contain several kinds of triterpenoid saponin with high preventive medicine values. This study investigates the impacts of sulfur processing soybean cultivated with sulfur processing were examined for it configurational property, and then compared with soybean without sulfur processing as a control. A significant decrease in crude saponin content of observed with sulfur processing. Contents of crude saponin decreased about 53% more than non-treated soybean. These results suggest that sulfur processing could be used in the production of teriterpene saponins.
Direct Detection of Drug-Resistant Hepatitis B Virus in Serum Using a Dendron-Modified Microarray
( Doo Hyun Kim ),( Hong Seok Kang ),( Seong-suk Hur ),( Seobo Sim ),( Sung Hyun Ahn ),( Yong Kwang Park ),( Eun-sook Park ),( Ah Ram Lee ),( Soree Park ),( So Young Kwon ),( Jeong-hoon Lee ),( Kyun-hw 대한간학회 2018 Gut and Liver Vol.12 No.3
Background/Aims: Direct sequencing is the gold standard for the detection of drug-resistance mutations in hepatitis B virus (HBV); however, this procedure is time-consuming, labor-intensive, and difficult to adapt to high-throughput screening. In this study, we aimed to develop a dendron-modified DNA microarray for the detection of genotypic resistance mutations and evaluate its efficiency. Methods: The specificity, sensitivity, and selectivity of dendron-modified slides for the detection of representative drug-resistance mutations were evaluated and compared to those of conventional slides. The diagnostic accuracy was validated using sera obtained from 13 patients who developed viral breakthrough during lamivudine, adefovir, or entecavir therapy and compared with the accuracy of restriction fragment mass polymorphism and direct sequencing data. Results: The dendron-modified slides significantly outperformed the conventional microarray slides and were able to detect HBV DNA at a very low level (1 copy/μL). Notably, HBV mutants could be detected in the chronic hepatitis B patient sera without virus purification. The validation of our data revealed that this technique is fully compatible with sequencing data of drug-resistant HBV. Conclusions: We developed a novel diagnostic technique for the simultaneous detection of several drug-resistance mutations using a dendron-modified DNA microarray. This technique can be directly applied to sera from chronic hepatitis B patients who show resistance to several nucleos(t)ide analogues. (Gut Liver 2018;12:331-341)
조남경(Cho, Nam-kyung),김채형(Kim, Chae-Hyong),김성룡(Kim, Sung-Ryung),임지혁(Lim Ji-Hyuk),김성혁(Kim Sung-Hyuk),우성필(Woo, Sung-phil),박재영,소윤석(So, Yoon-seok),이정호(Lee, Jung-ho),이승재(Lee Seong-ja),전준수(Jeon Jun-su),황창환(Hw 한국항공우주연구원 2023 항공우주산업기술동향 Vol.21 No.2
고고도 환경 하에서 작동하는 발사체 엔진의 개발 시에는 반드시 실제 비행환경과 유사한 환경 하에서 정확한 추력 및 시동특성을 검증해야 한다. 따라서 고공환경 모사시험을 통하여 엔진의 성능을 확인해야 한다. 본 논문에서는 지상 대기조건 시험설비에서의 시험과는 달라야 하는 고공모사시험 및 설비의 필요성, 고공모사의 원리, 고공모사 설비의 종류 및 구성, 고공모사 설비의 설계 및 운용에 대해 기술한다. 특히 팽창비가 큰 상단엔진의 고공 시동/종료 성능과 쓰로틀링 성능, 재점화 성능 등을 파악할 수 있고 종료시 고팽창비 노즐의 좌굴을 방지할 수 있는 스팀이젝터 방식 고공모사설비에 대해 논의한다. The development of a launch vehicle engine operating in a high-altitude environment must include verifcation of accurate thrust and starting characteristics under an environment similar to the actual flight environment, therefore, the performance of the engine must be confirmed through a high-altitude environment simulation test. This paper describes the need for high-altitude simulation test facility. The principles, configurations, design and operation of high-altitude simulation test facility are discussed. In particular, overall aspects of steam ejector type facility for testing upper engine with a high expansion ratio are deeply discussed.
Seong Soo Kang, Se Eun Kim, Kyung Mi Shim, Seok Hwa Choi 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.2
The current study was conducted in order to investigate bone formation using matrigel and angiogenic factors with HA and poly ε-caprolactone (HA/PCL) in a rat calvarial defect model. Calvarial defect formation was surgically created in Sprague Dawley rats (n=36). Rats in the control group (CD group, n=6) did not receive a graft. The HA/PCL scaffold was grafted with matrigel (M-HA/PCL group, n=6) or without matrigel (HA/PCL group, n=6); and 100 ng of vascular endothelial growth factor with HA/PCL scaffold containing matrigel (VEGF100 group, n=6), 100 ng (PDGF100 group, n=6) and 300 ng (PDGF300 group, n=6) of PDGF with HA/PCL scaffold containing matrigel were grafted in calvarial defects, respectively. Four weeks after surgery, bone formation was evaluated with micro computed tomography (micro CT) scanning, and histologically. According to the results, bone mineral density was significantly increased in the VEGF100, PDGF100, and PDGF300 groups compared to the HA/PCL group, in which angiogenic factors were not applied. In histological evaluation, more new bone formation around scaffolds was observed in the PDGF100 and the PDGF300 groups, compared with the VEGF100 group. Thus, the results indicate that HA/PCL containing matrigel with VEGF and PDGF is an effective grafting material for enhancement of bone formation in critical-sized bone defects. Especially, due to its price and capacity for bone formation, PDGF may be more effective than VEGF.
Yoon soo Park,Hyun Jin Tae,Jeong Hwi Cho,In Shik Kim,Taek Geun Ohk,Chan Woo Park,Joong Bum Moon,Myoung Cheol Shin,Tae Kyeong Lee,Jae Chul Lee,Joon Ha Park,Ji Hyeon Ahn,Seok Hoon Kang,Moo Ho Won,Jun Hw 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.2
Cardiac arrest (CA) is sudden loss of heart function and abrupt stop in effective blood flow to the body. The patients who initially achieve return of spontaneous circulation (RoSC) after CA have low survival rate. It has been known that multiorgan dysfunctions after RoSC are associated with high morbidity and mortality. Most previous studies have focused on the heart and brain in RoSC after CA. Therefore, the aim of this research was to perform serological, physiological, and histopathology study in the lung and to determine whether or how pulmonary dysfunction is associated with low survival rate after CA. Experimental animals were divided into sham-operated group (n=14 at each point in time), which was not subjected to CA operation, and CA-operated group (n=14 at each point in time), which was subjected to CA. The rats in each group were sacrificed at 6 hours, 12 hours, 24 hours, and 2 days, respectively, after RoSC. Then, pathological changes of the lungs were analyzed by hematoxylin and eosin staining, Western blot and immunohistochemistry for tumor necrosis factor (TNF-). The survival rate after CA was decreased with time past. We found that histopathological score and TNF- immunoreactivity were significantly increased in the lung after CA. These results indicate that inflammation triggered by ischemia-reperfusion damage after CA leads to pulmonary injury/dysfunctions and contributes to low survival rate. In addition, the finding of increase in TNF- via inflammation in the lung after CA would be able to utilize therapeutic or diagnostic measures in the future.
Ji-Ae Lim,Ho-Jang Kwon,Mina Ha,Ho Kim,Se Young Oh,Jeong Seon Kim,Sang-Ah Lee,Jung-Duck Park,Young-Seoub Hong,Seok-Joon Sohn,Heesoo Pyo,Kyung Su Park,Kwang-Geun Lee,Yong Dae Kim,Sangil Jun,Myung Sil Hw 환경독성보건학회 2015 환경독성보건학회지 Vol.30 No.-
Objectives: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). Methods: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. Results: Pb and Cd were the highest (median value) in the seaweed (94.2 μg/kg for Pb; 594 μg/kg for Cd), and Hg was the highest in the fish (46.4 μg/kg). The dietary exposure level (median value) of Pb was 0.14 μg/kg body weight (bw)/d, 0.18 μg/kg bw/d for Cd, and 0.07 μg/kg bw/d for Hg. Those with a blood Pb level of less than 5.00 μg/dL (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than 0.30 μg/L (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than 5.00 μg/L (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. Conclusions: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.
( Jin Won Chang ),( Jae Seung Lee ),( Hye Won Lee ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Yeon Seok Seo ),( Han Ah Lee ),( Mi Na Kim ),( Yu Rim Lee ),( Seong Gyu Hw 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Several prediction scores are available for the early detection of hepatocellular carcinoma (HCC). We validated the predictive accuracy of the AASL, RESCUE-B, PAGE-B, and modified PAGE-B (mPAGE-B) scores in patients with chronic hepatitis B (CHB) treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF). Methods: Between 2007 and 2014, 3,171 patients were recruited (1,645 with ETV and 1,517 with TDF). The predictive accuracy of each prediction score was assessed. Results: The mean age of the study population (1,977 men and 1,194 women) was 48.8 years. Liver cirrhosis was noted in 1,040 (32.8%) patients. During follow-up (median, 58.2 months), 280 (8.8%) patients developed HCC and were significantly older; were more likely to be male; had significantly higher proportions of liver cirrhosis, hypertension, and diabetes; and had significantly higher values of the four risk scores than those who did not develop HCC (all P<0.05). Older age (hazard ratio [HR]=1.048), male sex (HR=2.142), liver cirrhosis (HR=3.144), and prolonged prothrombin time (HR=2.589) were independently associated with an increased risk of HCC development (all P<0.05), whereas a higher platelet count (HR=0.996) was independently associated with a decreased risk (P<0.05). The predictive accuracy of the AASL score was highest at 3 and 5 years HCC prediction (area under the curve [AUC]=0.818 and 0.816, respectively), followed by RESCUE-B, PAGE-B, and mPAGE-B scores (AUC=0.780-0.815 and 0.769-0.814, respectively). Conclusions: Four HCC prediction scores performed acceptably in Korean patients with CHB treated with ETV or TDF. Of these, the AASL score showed the highest predictive accuracy.