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      저자 : Kim Pit Na (검색결과 3 건)
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      • Antigastritic Effects of Fruit of Poncirus trifoliata in rats

        Lee, Yu Mi,Kim, Pit Na,Jeong, Choon Sik 덕성여자대학교 대학원 2008 덕성여자대학교 대학원 논문집 Vol.10 No.-

        We investigated the effects of Poncirus trifoliate (P.trifoliate) (Ponciri Fructu, PF) extract and its constituents on gastritis in rats and human gastric cancer cells. The PF 70% ethanol extracts showed the acid-neutralizing capacities and cytotoxicity against human AGS gastric cancer cells. Neohesperidin and poncirin significantly inhibited HCl.ethanol-induced gastric lesions and increased the mucus content. In pylorus ligated rats, neohesperidin significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. From these results, we could suggest that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.

      • Antigastritic Effects of Fruit of Poncirus trifoliata in rats

        Lee, Yu Mi,Kim, Pit Na,Jeong, Choon Sik 德成女子大學校 藥學硏究所 2008 藥學論文誌 Vol.19 No.-

        We investigated the effects of Poncirus trifoliate (P. trifoliate) (Ponciri Fructus, PF) extract and its constituents on gastritis in rats and human gastric cancer cells The PF 70% ethanol extracts showed the acid-neutralizing capacities and cytotoxicity against human AGS gastric cancer cells. Neohesperidinand poncirin significantly inhibited HCl·ethanol-induced gastric lesions and increased the mucus content. In pylorus ligated rats, neohesperidinsignificantly decreased the volume of gastric secretion and gastric acid output,and increased the pH. From these results, we could suggest that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.

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        Anti-Gastritis and Anti-Oxidant Effects of Chenopodium album Linne Fractions and Betaine

        ( Choon Sik Jeong ),( Pit Na Kim ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4

        Chenopodium album Linne (CAL) is a fast-growing weedy annual plant. The leaves and young shoots may be eaten as a leafy vegetable. In oriental medicine, CAL has been used for treatment of skin disease, fever, stomach ache, toothache, and paralysis. After a preliminary screening of CAL ethanol extract and its fractions obtained from CAL leaves for anti-gastritic and anti-Helicobacter pylori (H. pylori) activity, the butanol (BuOH) fraction was found to have the most significant effect. We also examined antioxidative properties of the total CAL extract and its fractions, and also betaine as an ingredient of the BuOH fraction. To investigate the antioxidant effects of CAL on gastritis, the reducing power, free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH), and lipid peroxidation effects were determined. Additionally, the BuOH fraction reduced cell viability in a concentration dependent manner in human gastric cancer cell lines. The results of this study revealed that CAL has excellent antioxidant activity, and may be useful in treating gastritis and gastric cancer.

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