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      • 유산양 유방염에 대한 Chitosan 약침의 치료 효과

        황수현,서진석,김덕환,김명철,신상태,전무형,南三郞,김영찬,이우근,표수일 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-

        To improve the therapeutic method for mastitis, treatment effect of chitosan pharmacopuncture was examined in three milking goats(A,B and C). Mastitis was artificially induced in two milking goats(A and B) and one goat(C) was naturally infected case with mastitis. The acupoint used was Yang-Ming and chitosan suspensions(provided from Tottory University, Japan: 30㎎ of chitosan/㎖)were injected to the acupoint with 5㎖/time for 3 days, respectively. As for the change of somatic cells in milk along with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in all udders of B. In addition, as for the change of total leukocyte counts of peripheral blood with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in B and C except A which showed a increasing tendency until on the 7th day. In the change of neutrophil/lymphocyte(N/L) ratio, increasing tendency was seen in A and C but increasing tendency after slight decrease was observed in B. Further, in the change of serum total protein and A/G ratio, serum total protein content was decreased after slightly increase on the 3rd day in A, and they were decreased after increase until on the 7th day in B and C, respectively. As for the change of A/G ratio, different pattern increasing tendency was shown in A, B and C.

      • 경연 대회를 통한 초ㆍ중고생의 창의력 신장 효과에 관한 연구

        이희복,육근철,류해일,김현섭,김희수,박달원,유병환,김선효,김여상,서광수,변두원,서명석,배성효,박종석,심규철,이성희 공주대학교 과학교육연구소 2001 과학교육연구 Vol.32 No.1

        미래 사회를 대비하기 위한 개인의 개성을 존중과 창의적인 능력을 지닌 인간을 양성을 목적으로 충청남도 지역의 초 ㆍ 중고등학생들을 대상으로 한 창의력 경연대회가 공주대학교 과학교육연구소에서 개최되었다. 충청남도 초 ㆍ중 ㆍ 고등학생들을 대상으로 실시한 창의력 경연대회는 창조적 아이디어를 내어 스스로 문제를 해결해 나갈 수 있는 교육 프로그램을 제공하는 좋은 기회였음이 확인되었으나, 일부의 팀에서만 참신하고 재미있는 아이디어들이 제안되었다. 여학생의 참가자 수가 상당히 증가하였으며, 대체적으로 입상권의 학생들의 상당 부분이 여학생이라는 것이 특이할만하다. 학년이 올라감에 따라서 창의적인 아이디어를 내는 양이나 질에 있어서 뒤떨어지는 것으로 분석되었으며, 토론 학습의 적응력이 미흡하고 발표력 및 청취력에 있어서도 떨어지는 것으로 나타났다. 따라서 중 ㆍ고등학교의 학교교육에서도 학생들에게 프로젝트형 탐구학습 프로그램의 적용은 물론 토론식 수습을 통한 학생들의 사고의 전환의 기회를 제공해야 할 것으로 사료된다. The creativity competition was held to foster the creativity of elementary and secondary school students in the Institute of Science Education, Kongju national University. It was found that the creativity competition effected on the improvement of inventing creative ideas and problem solving activities. But, only some competitors participated in semifinal and final contests, presented original and interesting ideas. More female students participated in competition than last year. More female participants were awarded a prize than males. Totally, participants were defective in discussion and communication, and presentation and listening ideas. Increasing grades correlated inversely with creativity and originality. There is need of inquiry project teaming programs and presenting opportunities of conversion of thinking by discussing instructions in school

      • 한국 발전국가의 변환

        金明秀 한양대학교 민족학연구소 2003 民族과文化 Vol.12 No.-

        한국의 20세기는 외세의 '강점'으로 시작되었고 IMF라는 외세를 '초대'하는 것으로 마무리 지었다. 이제 우리도 21세기에는 외부로부터의 충격을 세련되게 흡수하고 나름대로 목표를 설정해 나아갈 수 있는 국가 모형을 재정립해야 한다. 국가 변환의 문제가 단순한 이론적·학술적 호기심을 넘어서 우리에게 매우 중요한 실천적 함의를 갖는 이유가 바로 여기에 있으며, 이 글은 이러한 시대적 명제를 염두에 두고 작성되었다. 이른바 IMF 사태 이후, 한국에서는 매우 빠른 속도로 발전국가의 전형에서 신자유주의 국가(the neo-liberal state)로이 변환이 진행되어 왔다. 과연 한국이 지향하고 있는 신자유주의 국가로의 변환이 바람직하고, 또 가능한 것인가? 이 글은 한국에서 발전국가의 '성급한' 해체와 신자유주의국가로의 '설익은' 대체가 진행되었으며, 이러한 혼돈의 결과인 국가성격의 '복잡성'(hybridity)은 국가 능력을 현저히 훼손시키고 있다고 평가한다. 나아가 지속적 경제 성장을 통한 번영과 복지의 확대라는 상충적 요구를 조화시키는데서 국가의 유능한 역할이 '여전히' 필수적이며, 이러한 과제를 유능하게 수행할 수 있는 국가 형태로서 개발독재 시기 성장이 견인차였던 '사외로부터 유리된' 발전국가는 더 이상 허용되지 않고, 현재 세계화 시대의 유일한 대안을 간주되고 있는 신자유주의 국가도 유효하지 않다는 점을 주장한다. 그렇다면 실천 가능한 대안은 무엇인가? 이 글에서는 사회를 '통해서' 국가권력이 행사되는 모델의 가능성이 모색되었다.

      • Mycophenolic Acid와 Rapamycin이 흰쥐 사구체 혈관간세포증식과 세포외기질 생성에 미치는 영향

        김명수,박제현,하헌주,허규하,서지연,김유선,김혜진,박기일 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

        Background: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such as vascular smooth muscle cells (VSMC) and glomerular mesangial cells cause chronic allograft nephropathy showing transplant vascular sclerosis and glomerulosclerosis. Mycophenolic acid (MPA) and rapamycin (RPM) are well known as strong inhibitors of VSMC proliferation, but their effects on the glomerular mesangial cells are not yet clearly understood. This study examined the effects of MPA or RPM on PDGF-induced proliferation and ECM accumulation in rat glomerular mesangial cells. Methods: Mesangial cells isolated from the glomeruli of Sprague-Dawley rats were cultured with DMEM containing 20% fetal bovine serum. Growth arrested and synchronized cells were administered with test drugs (MPA10 nM-10μM, RPM 0.1 nM-1μM) before the addition of PDGF 10 ng/mL. Cell proliferation was assessed by [³H]thymidine incorporation, collagen by [³H]proline incorporation, and fibronectin, ERK, and p38 MAPK by Western blot analysis. Results: PDGF increased mesangial cell proliferation by 4.64-fold. Compared to stimulated control, MPA above 500 nM and RPM above 10nM showed a significant inhibitory effect in a dose-dependent manner. The IC_(50) of MPA and RPM against PDGF-induced mesangial cell proliferation were around 500 nM and 100 nM, respectively. The collagen synthesis was also inhibited by MPA and RPM, but the fibronectin secretion was inhibited by MPA alone. The proliferation of mesangial cell correlated with activation of ERK and. p38 MAPK. MPA, but not RPM, inhibited ERK and p38 MAPK activation. Conclusion: This study demonstrated that MPA and RPM significantly inhibited PDGF-induced proliferation and ECM production in rat glomerular mesangial cells. The inhibitory effects of MPA, but not RPM, are correlated with ERK and p38 MAPK.

      • 사회주의 체제의 변동과 북한사회의 변동 : A State-Society Interaction Model 국가-시민사회 상호작용 모델

        김명수 漢陽大學校 民族學硏究所 1996 民族과文化 Vol.4 No.-

        This study has an assumption that the North Korea, even with her particularistic character, shares the system-embedded problems with the collapsed socialist countries. In order to speculate social change of the North Korea, therefore, this study has built a model that explains the socialist system change by synthesizing the theories for socialist civil society and the party-state. The collapsed socialist party-stales had maintained their iron law for decades regardless of the chronic and fundamental problems, such as economic depression, shortage of dally goods, corruption, the wide discrepancy between the formal ideology and reality, and the development of civil society etc. It means that the state capacity of the socialist state had been strong enough to sustain the socialist system until the functional imperatives of the state capacity, -i.e., the organizational dependence, monitoring capacity, and sanctioning capacity- eroded substantially. It becomes clear that the socialist system collapse is the problem of 'weakness 'not of 'oppression' of the state. As for the North Korea, this study illustrates that the current economic crisis and heavy industrialization provide a favorable conditions for activation of the informal sector of economy and the emergent of civil society. Furthermore these factors are considered to undermine capacities of the state. We speculate, therefore, that changes in the political regime and the system are more likely to occur if a chasm develops substantially among the party-state elites.

      • 국가의 자율성과 개입력 : 한국의 중화학공업화 계획을 중심으로

        김명수 한양대학교 사회과학대학 1988 社會科學論叢 Vol.7 No.-

        Contrary to the conventional image of an "ever-strong" Korean state in the literature, the strength of the Korean state which we could observe in the process of the state-initiated Heavy and Chemical Industrialization (HCI) was far from being strong. Although the state achieved same of its autonomously driven objectives, the shape of the project was not the one which the state intended to have. The particular shape and content of the HCI project compell us to rethink the conventional theories of the "dependent" capitalist state. At the outset of the HCI project, the Korean state had relatively high degrees of state autonomy and intervening capacity at its disposal. The state could initiate the HCI project in accordance with its own purview, most importantly, the development of self-defense industry, the deepening-of industrial structure, and the renewal of decaying political legitimacy of the President Park. The state could wield its discretionary poller over the big business groups, Jaebols, by setting terms of their entry in the HCI project. However, the Korean state put itself into a precarious position vis-a-vis Jaebols by deeply committing itself to the HCI project. The Jaebols aggressive thrust for hegemonic position in the Korean economy paralyed the strategic decision-making apparatus of the state. Incongruence among the strategic units within the state resulted in a series of incongruent state actions and a massive scales of duplicated overinvestment in the HCI sector. The state intervention in realigning the disarray was abortive primarily because the Jaebols refused to follow the state's direction and because a unit of the state apparatus 'revolted' against the state's own action. By then, the autonomy and intervening capacity' of the Korean state vis-a-vis'is the Jaebols had substantially been eroded. It is clear that the terms of alliance between the Korean state and Jaebols underwent a substantial transformation during the course of the HCI project. The case succinctly illustrates that strong state intervention with highly autonomous objectives could undercut the state strength. The above point substantially negates the utility of the static and overall typology of the state strength, either "strong state" or "weak state." It also illustrates the inadequacy of "society-centered" theories of the state, either neo-Marxist theories of "the" class-bounded capitalist state or pluralist theories of the "neutral" state. Since both perspectives deny the possibility that the state could generate and pursue autonomous objectives, both are inadequate in explaining the Korean state's action in the HCI project. Instead, it strongly suggests that it is necessary to conceive the state in its own terms.

      • 兒童彫塑에 있어서 運動하는 사람의 表現의 變容

        金壽命 대구교육대학교 1976 論文集 Vol.12 No.-

        Developmental changes in the recognition and the expession of moving shapes in the Primary School children were studied by surveying their sculptures of moving human fighres. Four types of expression were found. 1. Upright type: The body stands upright. Movement is expressed mainly by means of changing te shape of upper limbs.(lower grades; ages 6~7) 2. Inclining type: Movement is expressed by means of inclining the body and changing the shape of the upper and the lower limbs. This is the inclined expression of the upright type.(middle grade:ages 8~9) 3. Bending type:children notice the bending forward and backward of the body in motion. The movement is expressed by means of curved lines of the body. (middle grades:ages8~12) 4. Tuisting type:The movement is expressed by means of tucisting the body right or left and coordinating whole body and limbs in motion.(upper grades:ages 11~12)

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