http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
요중 N-acetyl-β-D-glucosaminidase 활성치를 이용한 신발제조업 근로자들의 만성 신기능 장애 평가
김돈균,이수일,조병만,이지호,이후락,박종욱 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1
부산지역 신발제조업 근로자중 유기용제에 폭로되고 있는 150명을 폭로군으로 하고, 일반사무직 근로자 53명을 대조군으로 하여 인적특성, 직업에 대한 만족도, 자각증상, 작업과 관련된 스트레스의 정도를 조사하고, 유기용제 폭로량의 지표가 되는 요중 마뇨산 및 근로자 건강진단 항목인 혈중 요소질소, 혈청 크레아티닌 그리고 조기 신기능 장애의 지표로 알려진 요중 NAG 활성치를 측정하여 얻은 바를 아래와 같이 요약한다. 1. 요중 NAG 활성치는 폭로군에서 4.63U/g creatinine, 대조군에서 2.95U/g creatinine로 폭로군에서 높게 측정되었고(p<0.05), 유기용제 폭로에 의한 신기능 변화에 민감한 결과를 보였다. 2. 설문조사에서 직업에 대한 불만족, 이직을 원하는 경우, 건강에 대한 염려, 직업과 관련된 스트레스 및 유기용제 폭로와 관련된 증상호소가 대조군에 비해 폭로군에서 유의하게 증가되어 있어(p<0.05), 유기용제에 폭로되고 있는 신발제조업 근로자들의 보건관리는 산업보건학적 측면에서 매우 중요한 것으로 나타났다. 3. 폭로군중 근무기간 5년 이상인 대상자에서 요중 NAG 활성치는 5.92U/g creatinine, 근무기간 5년 미만인 경우 4.34U/g creatinine으로, 유기용제 폭로 기간이 길어짐에 따라 요중 NAG활성치는 통계학적으로 유의하게 증가되어 있었다(p<0.05). 4. 요중 NAG활성치는 근무기간을 가중한 톨루엔 총 폭로량과 유의한 정의 상관관계를 보여(p<0.05), 용량-반응관계를 보여 주었다. 이상의 결과에서, 복합유기용제에 만성적으로 폭로되는 근로자들에 공통적으로 발생할 수 있는 조기 신기능 장애를 감시하기 위하여, 요중 NAG활성치를 측정한 자료를 이용하면 유기용제 폭로 근로자들의 보건관리를 위하여 자료를 제공할 수 있을 것으로 생각된다. Personal characteristics, degree of satisfaction for work, subjective symptoms, and stress related to working condition were investigated from 150 workers exposed to organic solvents in shoe factories and 53 official workers in Pusan area, and urinary hippuric acid concentration which represented the amount of exposed organic solvents, BUN and serum creatinine which were renal function tests for worker's health examination and urinary N-acetyl-β-D-glucosaminidase activity were measured. The results obtained were summarized as follows. 1. The mean value of urinary NAG activity of exposed group was higher than that of control group(p<0.01), and subjects whose NAG activities were over refrence range in exposed group were far more than in control group(p<0.05), therefore urinary NAG activity was a sensitive test for the change of renal function due to exposure of organic solvents. 2. Unsatisfaction for occupation, want to change occupation, worry about health, stress related to job and symptoms related to exposure of organic solvents investigated by questionnaire were higher in exposed group than in control group, therefore the health management for workers exposed to organic solvents in shoe factories was important in the viewpoint of occupational medicine. 3. The mean value of urinary NAG activity in the subjects whose working duration were over 5 years was higher than in the subjects whose working duration were over 5 years was higher than in the subjects whose working duration were under 5 years, therefore the longer exposured duration was, the higher urinary NAG activity was. 4. Urinary NAG activity had positive correlation with time weighted amount of total toluene exposure therefore dose-response relationship was suspected. As above results, it will be very useful to apply the data of urinary NAG activity to the health management of workers exposed to orgaic solvents in order to monitoring of early renal dysfunction which was common in the workers chornically exposed to mixed organic solvents.
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
Kim, Jongshin,Kim, Yoo Hyung,Kim, Jaeryung,Park, Do Young,Bae, Hosung,Lee, Da-Hye,Kim, Kyun Hoo,Hong, Seon Pyo,Jang, Seung Pil,Kubota, Yoshiaki American Society for Clinical Investigation 2017 The Journal of clinical investigation Vol.127 No.9
An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies
Heo, Kyun,Min, Sung-Won,Sung, Ho Jin,Kim, Han Gyul,Kim, Hyun Jung,Kim, Yun Hee,Choi, Beom Kyu,Han, Sewoon,Chung, Seok,Lee, Eun Sook,Chung, Junho,Kim, In-Hoo Elsevier 2016 Journal of controlled release Vol.229 No.-
<P><B>Abstract</B></P> <P>Aptamers have recently emerged as reliable and promising targeting agents in the field of biology. However, their therapeutic potential has yet to be completely assessed due to their poor pharmacokinetics for systemic administration. Here, we describe a novel aptamer-antibody complex, designated an “oligobody” (<U>oligo</U>mer+anti<U>body</U>) that may overcome the therapeutic limitations of aptamers. To provide proof-of-principle study, we investigated the druggability of oligobody <I>in vivo</I> using cotinine conjugated t44-OMe aptamer, which is specific for the sequence of pegaptanib, and an anti-cotinine antibody. The antibody part of oligobody resulted in extended <I>in vivo</I> pharmacokinetics of the aptamer without influencing its binding affinity. Moreover, the aptamer of oligobody penetrated deeply into the tumor tissues whereas the anti-VEGF antibody did not. Finally, the systemic administration of this oligobody reduced the tumor burden in a xenograft mouse model. Together, these results suggested that our oligobody strategy may represent a novel platform for rapid, low-cost and high-throughput cancer therapy.</P> <P><B>Graphical abstract</B></P> <P> <B>Aptamer-antibody hybrid complex</B>: Because the oligobody requires only a single antibody and utilizes a simple antigen–antibody reaction, it could offer the benefits of aptamers and antibodies, and may be a potentially valuable tool for cancer therapeutics.</P> <P>[DISPLAY OMISSION]</P>
Moon Joon Ho,Lee Joonyub,Kim Kyun Hoo,Kim Hyun Jung,Kim Hyeongseok,Cha Hye-Na,Park Jungsun,Lee Hyeonkyu,Park So-young,Jang Hak Chul,Kim Hail 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Pregnancy imposes a substantial metabolic burden on women, but little is known about whether or how multiple pregnancies increase the risk of maternal postpartum diabetes. In this study, we assessed the metabolic impact of multiple pregnancies in humans and in a rodent model. Mice that underwent multiple pregnancies had increased adiposity, but their glucose tolerance was initially improved compared to those of age-matched virgin mice. Later, however, insulin resistance developed over time, but insulin secretory function and compensatory pancreatic β cell proliferation were impaired in multiparous mice. The β cells of multiparous mice exhibited aging features, including telomere shortening and increased expression of Cdkn2a. Single-cell RNA-seq analysis revealed that the β cells of multiparous mice exhibited upregulation of stress-related pathways and downregulation of cellular respiration- and oxidative phosphorylation-related pathways. In humans, women who delivered more than three times were more obese, and their plasma glucose concentrations were elevated compared to women who had delivered three or fewer times, as assessed at 2 months postpartum. The disposition index, which is a measure of the insulin secretory function of β cells, decreased when women with higher parity gained body weight after delivery. Taken together, our findings indicate that multiple pregnancies induce cellular stress and aging features in β cells, which impair their proliferative capacity to compensate for insulin resistance.