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Lee, Dahae,Lee, Dong-Soo,Jung, Kiwon,Hwang, Gwi Seo,Lee, Hye Lim,Yamabe, Noriko,Lee, Hae-Jeong,Eom, Dae-Woon,Kim, Ki Hyun,Kang, Ki Sung The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.1
Background: The aim of the present study was to evaluate the potential protective effects of six ginsenosides (Rb1, Rb2, Rc, Rd, Rg1, and Rg3) isolated from Panax ginseng against tacrolimus (FK506)-induced apoptosis in renal proximal tubular LLC-PK1 cells. Methods: LLC-PK1 cells were treated with FK506 and ginsenosides, and cell viability was measured. Protein expressions of mitogen-activated protein kinases, caspase-3, and kidney injury molecule-1 (KIM-1) were evaluated by Western blotting analyses. The number of apoptotic cells was measured using an image-based cytometric assay. Results: Reduction in cell viability by $60{\mu}M$ FK506 was ameliorated significantly by cotreatment with ginsenosides Rg1 and Rb1. The phosphorylation of p38, extracellular signal-regulated kinases, and KIM-1, and cleavage of caspase-3, increased markedly in LLC-PK1 cells treated with FK506 and significantly decreased after cotreatment with ginsenoside Rb1. The number of apoptotic cells decreased by 6.0% after cotreatment with ginsenoside Rb1 ($10{\mu}M$ and $50{\mu}M$). Conclusion: The antiapoptotic effects of ginsenoside Rb1 on FK506-induced apoptosis were mediated by the inhibition of mitogen-activated protein kinases and caspase activation.
Kim Hyunglae,정선아,Kim Kyeong Min,Hwang Sun Deuk,Choi Sun Ryoung,Lee Hajeong,Kim Ji Hyun,김수현,Kim Tae Hee,Koo Ho-Seok,Yoon Chang-Yun,Kim Kiwon,안선호,윤혜은,Kim Yong Kyun,반태현,홍유아 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.3
With an increasing aging population, the mean age of patients with end-stage kidney disease (ESKD) is globally increasing. However, the current clinical status of elderly patients undergoing hemodialysis (HD) is rarely reported in Korea. The current study analyzed the clinical features and trends of older patients undergoing HD from the Korean Renal Data System (KORDS) database. The patients were divided into three groups according to age: <65 years (the young group), n = 50,591 (35.9%); 65–74 years (the younger-old group), n = 37,525 (26.6%); and ≥75 years (the older-old group), n = 52,856 (37.5%). The proportion of older-old group undergoing HD significantly increased in incidence and decreased in prevalence from 2013 to 2022. The median levels of hemoglobin, serum creatinine, albumin, calcium, phosphorus, and intact parathyroid hormone significantly decreased in the older-old group. The proportions of arteriovenous fistula creation and left forearm placement showed decreased trends with age. Although the utilization of low surface area dialyzers increased with age, the dialysis adequacy, including urea reduction ratio and Kt/V was within acceptable range in the older-old group on HD. Over the past 20 years, the mortality rate in the older-old group has increased, with cardiovascular diseases decreasing and infectious diseases increasing. The incidence of elderly patients undergoing HD has increased over time, but the high mortality of the older-old group needs to be solved. Therefore, it is imperative to develop holistic strategies based on age and individual needs for patients with ESKD.
Kim Jin-Ju,Park Jae-Hyun,Kim Hyeok,Sim Woo-Sup,Hong Seokbeom,Choi Yeon-Jik,Kim Hyo-Jin,Lee Soon Min,Kim Dongha,Kang Sun-woong,Ban Kiwon,Park Hun-Jun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Despite recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells and growth factors have been assessed for use in therapeutic neovascularization and limb salvage in CLI patients. However, the clinical outcomes of cell-based therapeutic angiogenesis have not provided the promised benefits, reinforcing the need for novel cell-based therapeutic angiogenic strategies to cure untreatable CLI. In the present study, we investigated genetically engineered mesenchymal stem cells (MSCs) derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α-eMSCs) and demonstrated that intramuscular injection of SDF1α-eMSCs can provide long-term paracrine effects in limb ischemia and effectively contribute to vascular regeneration as well as skeletal muscle repair through increased phosphorylation of ERK and Akt within the SDF1α/CXCR4 axis. These results provide compelling evidence that genetically engineered MSCs with SDF-1α can be an effective strategy for successful limb salvage in limb ischemia.
Kim, Chulki,Oh, Kiwon,Han, Seunghee,Kim, Kyungkon,Kim, Il Won,Kim, Heesuk American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.8
<P>The direct spontaneous grafting of 4-nitrophenyl molecules onto n-doped hydrogenated amorphous silicon (a-Si:H) surfaces without external ultraviolet, thermal, or electrochemical energy was invegtigated. Clean n-doped a-Si:H thin films were dipped in a solution of 4-nitrobenzenediazonium salts (PNBD) in acetonitrile. After the modified surfaces were rinsed, they were analyzed qualitatively and quantitatively by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). XPS and AFM results show that the reaction of an n-doped a-Si:H thin film with PNBD self-terminates without polymerization, after 5 h, and the surface number density of 4-nitrophenyl molecules is 4.2 x 10(15)/cm2. These results demonstrate that the spontaneous grafting of nitrophenyl layers onto n-doped a-Si:H thin films is an attractive pathway toward forming interfaces between a-Si:H and organic layers under ambient conditions.</P>
RELATIONS BETWEEN CERTAIN DOMAINS IN THE COMPLEX PLANE AND POLYNOMIAL APPROXIMATION IN THE DOMAINS
Kim, Kiwon Korean Mathematical Society 2002 대한수학회보 Vol.39 No.4
We show that the class of inner chordarc domains is properly contained in the class of exterior quasiconvex domains. We also show that the class of exterior quasiconvex domains is properly contained in the class of John disks. We give the conditions which make the converses of the above results be true. Next , we show that an exterior quasiconvex domain satisfies certain growth conditions for the exterior Riemann mapping. From the results we show that the domain satisfies the Bernstein inequality and the integrated version of it. Finally, we assume that f is a function which is continuous in the closure of a domain D and analytic in D. We show connections between the smoothness of f and the rate at which it can be approximated by polynomials on an exterior quasiconvex domain and a $Lip_\alpha$-extension domain.
Electronic structures and relevant physical properties of Ni2MnGa alloy films
Kiwon Kim,Jinbae Kim,Jooyull Rhee,Meidong Huang,Nina Lee,이영백,Yurie Kudryavtsev 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1
The electronic structures and physical properties of the ordered and disordered Ni2MnGa alloy lms were investigated in this study. Ordered and disordered Ni2MnGa alloy lms were prepared by ash evaporation onto substrates maintained at 720 K and 150 K, respectively. The results show that the ordered lms behave in nearly the same way as the bulk Ni2MnGa ferromagnetic shape-memory alloy, including the martensitic transformation at 200 K. It was also revealed that the lm deposition onto substrates cooled by liquid nitrogen leads to the formation of a substantially-disordered or an amorphous phase which is not ferromagnetically ordered at room temperature. An annealing of such an amorphous lm restores its crystallinity and also recovers the ferromagnetic order. It was also claried how the structural disordering in the lms in uences the physical properties, including the loss of ferromagnetism in the disordered lms, by performing electronic-structure calculations and a photoemission study.
Continuous ZIF-8/reduced graphene oxide nanocoating for ultrafast oil/water separation
Kim, Dae Woo,Eum, Kiwon,Kim, Hanim,Kim, Daeok,Mello, Matheus Dorneles de,Park, Kangho,Tsapatsis, Michael Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.372 No.-
<P><B>Abstract</B></P> <P>Continuous ZIF-8/reduced graphene oxide (RGO) nanocoating is fabricated by growing ZIF-8 on RGO-coated polyurethane (PU) foam. Surface modification of PU foam can be easily achieved by immersing the PU foam in GO solution, followed by mild thermal treatment to turn the GO layer into RGO layer. Adhesion between polymer foam and ZIF-8 layer was enhanced by the inserted RGO layer because oxygen-containing groups of RGO could interact with Zn<SUP>2+</SUP> precursor of ZIF-8 localizing the layer growth preferentially on the surface of RGO. The synergetic hydrophobic/oleophilic properties of RGO and ZIF-8 enable selective oil absorption of PU foam with an absorption capacity of 15–35 g/g depending on the viscosity of organic solvents. Most of all, the ZIF-8/RGO coated PU foam can filter organic solvent selectively <I>via</I> vacuum filtration, showing ultrafast hexane flux up to 800,000 Lm<SUP>−2</SUP> h<SUP>−1</SUP> and no water flux.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A method to fabricate continuous hydrophobic/oleophilic RGO/ZIF-8 nanocoating on polymeric foam. </LI> <LI> Selective oil absorption with an absorption capacity of 15–35 g/g depending on the viscosity of organic solvents. </LI> <LI> Ultrafast hexane flux up to 800,000 Lm<SUP>−2</SUP> h<SUP>−1</SUP> and no water flux during vacuum filtration. </LI> <LI> Universal method to fabricate metal-organic frameworks on polymeric foam. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kiwon Kim 경북대학교 자연과학대학 수학과 2003 Kyungpook mathematical journal Vol.43 No.3
Suppose that E is a bounded continuum whose complement in the extended complex plane is connected and that g is a conformal mapping from the complement of the closure of the unit disk in the extended complex plane to the complement of E in the extended complex plane with g(1 ) = 1 .In this paper we give some necessary and sufficient conditions for a growth condition of the exterior conformal mapping g which satisfies jg0(w)j m(11jwj2 )k; 1 < jwj < 1 for some 0 k < 1 and m > 0.