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- 저자 : Kim Kang-Seob (검색결과 822 건)
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구일섭,김태성,이강인 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2
The purpose of this research is to suggest the policy making for the effective promotion of Quality Small-Group activity. Since 1975, variety of organizations in Korea have widely the implemented Quality Small-Group activities for their management systems. Today, Companies are facing the harsh realities of a competitive environment. This is no time for revolutionary change. Instead, Companies are instituting revolutionary change meant to have impact within a very short time frame. Bold steps are required to lead the industry into a future of improved efficiency and significant productivity gains. The Worker's Quality Small-Group activity is, essentially, a trouble shooting oriented voluntary small group within their working place to improve the surroundings creatively. The industries have enthusiastically used Quality Small-Group activities and were influenced from them. The Quality Small-Group activities can be regarded as a kind of Knowledge Management where new knowledge is created and knowledge is shared in the economy. However, the academics were less interested in this subject, as a result, there were no systematic guidances for Quality Circle activities. Also, the government was less interested in these activities, as a result, there were no systematic policy making for Quality Small-Group activities. Thus, in this research, the effective policy making for Quality Small-Group activities were suggested which were based on the results of survey Questionnaires. As a results of this research, to maximize the effect of TQM in the nationwide, Quality Small-Group activity as a bottom-up management should be more expanded and revitalized.
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주요우울증에 대한 Milnacipran의 효과 및 안정성 : Fluoxetine과의 비교
이민수,함병주,기백석,김정범,연병길,오강섭,오병훈,이철,정한용,지익성,최병무,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This 6-week, open label randomized, multicenter study was conducted to evaluate the antidepressant effect and safety of milnacipran and fluoxetine in patients with major depression. Methods : The study was done in patients with major depression diagnosed by DSM-IV who score ≥17 in 17 items Hamilton Rating Scale for Depression (17-item HAM-D) and score ≥25 in Montgomery and Asberg Depression Rating Scale (MADRS). A total of 87 patients were randomized to milnacipran group and fluoxetine group. In cases of the patients taking other antidepressants, 6 weeks of each medication was administered after 7 days of drug excretion period. The evaluation was done using 17 item HAM-D, MADRS, Clinical Global Impression Scale (CGI), and COVI scale after baseline, 1 week, 2 weeks, 4 weeks, and 6 weeks. The side effects that had occurred during the period of our study were put in records by developed/disappeared time, severities, incidences, managements and results. Results : A total of 87 patients were enrolled. 70 (mitnacipran group 39 ; fluoxetine group 31) of them were included for the 6 weeks of research and 17 of them dropped out with in the first week, not due to adverse reactions or deficiency of effects. Total 17 item HAM-D scores, total points of MADRS, and CGI showed significant decrease after 1 week in each treatment group and continued decrease after 2 weeks and 4, 6 weeks. But there was no difference between milnacipran group and fluoxetine group in the antidepressant effect. There were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The commonly reported side elfects of minlacipran were nausea (25.0%), headache (10.7%), vomiting (7.1%),constipation (7.1%), dizziness (7.1%) and those of fluoxetne were GI trouble (11.1%), diarrhea (11.1%), insomnia (11.1%),agitation (5.6%), and dizziness (5.6%). Conclusion : Milnacipran was effective for the improvement of depressive symptoms and was well tolerated and safe in patients with depression.
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A Study on Fatigue Behavior of SM490A Steel under Low Temperature
Kang, Ki Weon,Goo, Byeong Choon,Kim, J.H.,Kim, Heung Seob,Kim, Jung Kyu Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.353-358 No.3
<P>This paper deals with the fatigue behavior and its statistical properties of SM490A steel at various temperatures, which is utilized in the railway vehicle. For these goals, the tensile ad fatigue tests were performed by using a servo-hydraulic fatigue testing machine at three temperatures: +20°C, -10°C and -40°C. The static strength and fatigue limits of SM490A steel were increased with decreasing of test temperature. The probabilistic properties of fatigue behavior are investigated by means of probabilistic stress-life (P-S-N) curve and they are well in conformance with the experimental results regardless of temperature. Also, based on P-S-N curves, the variation of fatigue life is investigated and as the temperature decreases, the variation of fatigue life increases moderately.</P>
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Role of proinflammatory cytokines in cisplatin-induced vestibular hair cell damage
Kim, Hyung-Jin,So, Hong-Seob,Lee, Jeong-Han,Park, Channy,Lee, Jin-Bin,Youn, Myung-Ja,Kim, Se-Jin,Yang, Sei-Hoon,Lee, Kang-Min,Kwon, Kang-Beom,Park, Byung-Hyun,Park, Raekil Wiley Subscription Services, Inc., A Wiley Company 2008 Head & neck Vol.30 No.11
<B>Background.</B><P>Cisplatin causes the impairment of inner ear functions, including hearing and balance, through the involvement of a number of mechanisms. However, no laboratory studies have been performed on involvement of inflammation-related events in cisplatin-mediated vestibular dysfunction.</P><B>Methods.</B><P>We evaluated the secretion of proinflammatory cytokines and nuclear factor-κB (NF-κB) activation in cisplatin-treated UB/UE-1 utricular epithelial cells. We also employed immunohistochemistry to detect proinflammatory cytokines and NF-κB expression in cisplatin-injected mice.</P><B>Results.</B><P>Productions of proinflammatory cytokines significantly caused the death of UB/UE1 cells by cisplatin. Pharmacologic inhibition of mitogen-activated protein (MAP) kinase/ERK kinase-1 (MEK1) or extracellular signal-regulated kinase (ERK) significantly attenuated the death of UB/UE1 cells caused by cisplatin and proinflammatory cytokines. Immunohistochemical studies revealed an increase in the expression of proinflammatory cytokines and NF-κB in both the cristae ampullae and utricle of cisplatin-injected mice.</P><B>Conclusions.</B><P>These results suggest that proinflammatory cytokines may play an important role in the pathogenesis of cisplatin-mediated vestibulotoxicity. © 2008 Wiley Periodicals, Inc. Head Neck, 2008</P>
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Fabrication of Small Reference Probe and Its Application
Kang, No-Weon,Kang, Jin-Seob,Kim, Dae-Chan,Kim, Jeong-Hwan Institute of Electrical and Electronics Engineers 2007 IEEE transactions on instrumentation and measureme Vol.56 No.2
<P> This paper presents a disk-type small reference probe operating up to 1 GHz as an electric field transfer sensor. The probe is calibrated using a <TEX>$\mu$</TEX>-TEM cell and demonstrates a wide useable electric field strength range. Design and calibration methods are presented. The probe is suitable for testing and comparing the performances of reference field generation systems, both TEM cells and antennas. As an application, a technique for measuring the antenna gain is proposed and applied to open-ended waveguide antennas. </P>
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Kim, Dajeong,Kyung, Jangbeen,Park, Dongsun,Choi, Ehn-Kyoung,Kim, Kwang Sei,Shin, Kyungha,Lee, Hangyoung,Shin, Il Seob,Kang, Sung Keun,Ra, Jeong Chan,Kim, Yun-Bae unknown 2015 Stem cells translational medicine Vol.4 No.10
<P>: Aging brings about the progressive decline in cognitive function and physical activity, along with losses of stem cell population and function. Although transplantation of muscle-derived stem/progenitor cells extended the health span and life span of progeria mice, such effects in normal animals were not confirmed. Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) (1 ?? 10(6) cells per rat) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives. Transplantation of AMMSCs and ADMSCs improved cognitive and physical functions of naturally aging rats, extending life span by 23.4% and 31.3%, respectively. The stem cell therapy increased the concentration of acetylcholine and recovered neurotrophic factors in the brain and muscles, leading to restoration of microtubule-associated protein 2, cholinergic and dopaminergic nervous systems, microvessels, muscle mass, and antioxidative capacity. The results indicate that repeated transplantation of AMMSCs and ADMSCs elongate both health span and life span, which could be a starting point for antiaging or rejuvenation effects of allogeneic or autologous stem cells with minimum immune rejection.</P>
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Kim, Han Wool,Lee, Hyun-Seob,Kang, Jun Mo,Bae, Sang-Hun,Kim, Chul,Lee, Sang-Hun,Schwarz, Johannes,Kim, Gi Jin,Kim, Jin-Su,Cha, Dong Hyun,Kim, Joopyung,Chang, Sung Woon,Lee, Tae Hee,Moon, Jisook Cognizant Communication Corp. 2018 CELL TRANSPLANTATION Vol. No.
<P>Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (DA) neurons on substantia nigra pars compacta (SNpc). We previously reported that transplantation of human fetal midbrain-derived neural precursor cells restored the functional deficits of a 6-hydroxy dopamine (6-OHDA)-treated rodent model of PD but its low viability and ethical issues still remain to be solved. Albeit immune privilege and neural differentiation potentials suggest mesenchymal stem cells (MSCs) from various tissues including human placenta MSCs (hpMSCs) for an alternative source, our understanding of their therapeutic mechanisms is still limited. To expand our knowledge on the MSC-mediated PD treatment, we here investigated the therapeutic mechanism of hpMSCs and hpMSC-derived neural phenotype cells (hpNPCs) using a PD rat model. Whereas both hpMSCs and hpNPCs protected DA neurons in the SNpc at comparable levels, the hpNPC transplantation into 6-OHDA treated rats exhibited longer lasting recovery in motor deficits than either the saline or the hpMSC treated rats. The injected hpNPCs induced delta-like ligand (DLL)1 and neurotrophic factors, and influenced environments prone to neuroprotection. Compared with hpMSCs, co-cultured hpNPCs more efficiently protected primary neural precursor cells from midbrain against 6-OHDA as well as induced their differentiation into DA neurons. Further experiments with conditioned media from hpNPCs revealed that the secreted factors from hpNPCs modulated immune responses and neural protection. Taken together, both DLL1-mediated contact signals and paracrine factors play critical roles in hpNPC-mediated improvement. First showing here that hpMSCs and their neural derivative hpNPCs were able to restore the PD-associated deficits via dual mechanisms, neuroprotection and immunosuppression, this study expanded our knowledge of therapeutic mechanisms in PD and other age-related diseases.</P>
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