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실험실적 당뇨성 흰쥐에서 acetaminophen의 대사에 관한 연구
임은주,윤병재,윤병재,조희숙,김대재,최종원 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1
Acetaminophen is one of the most important drugs used for the treatment of mild to moderate pain when an anti-inflammatory effect is not necessary. Phenacetin, a prodrug that is metabolized to acetaminophen, is more toxic than its active metabolite and has no rational indications. In this study, we were observed activities of free radical generating enzymes, free radical scavenging enzymes and glutathione-related enzymes as well as detoxification mechanism of against acetaminophen-induced hepatotoxicity in STZ-induced hyperglycemic rat. Activities of cytochrome p450, cytochrome b5, aminopyrine demethylase and aniline hydroxylase were changed by the treatment acetaminophen in hyperglycemic rats. It was also observed that activities of conjugating enzymes as sulfotransferase and UDP-glucuronyltransferase was slightly changes against acetaminophen-induced in hyperglycemic rats. Acetaminophen results in the significantly decrease in the level of hepatic glutathione concentration and √-glutamylcysteon, synthetase activities in hyperglycemic rats. And, glutathine S-transferase, superoxide dismutase and glutathione peroxidase activities were significantly increased against acetaminophen-inducedas in hyperglycemic rats. Glutathione reductase and catalase were not affected for experimental state. Furthemore, acetaminophen highered serum alanine, aspartate aminotransferase, sorbitol dehydrogenase, √-glutamylpeptidase, alkaline phosphatase and lactate dehydrogenase activities in hyperglycemic rats. Key Words: Hepatotoxicity, D/M, Acetaminophen, Glutathione, Glutathlone S-transferase, √-glutamylcystein synthetase
연구논문: 농촌 폐경 후 여성의 비만 지표에 따른 비만율 비교 및 혈중 지질과의 상호관련성
최정숙 ( Joeng Sook Choe ),김은경 ( Eun Kyung Kim ),박영희 ( Young Hee Park ) 한국식생활문화학회 2011 韓國食生活文化學會誌 Vol.26 No.6
This study was performed to examine the relationship between the body mass index (BMI), the body fat, and the serum lipids of post-menopausal women in rural areas. The subjects were 510 women aged 50 and over. As a result of this study, we found a trend of decreasing BMI as age increased, but body fat increased. In addition, there was a significant decreasing of the lean body mass than an increasing of the body mass index according to increasing age. Therefore, this study confirmed that a main cause of rural women being classified as obese is a decrease in lean body mass, rather than an increase in of body fat. Of all subjects, 36.3% (18.5 ≤ BMI < 23) of all subjects were classified as having normal BMI, whereas only 21.4% were classified as having normal body fat. Out of 190 subjects who were body fat 30% and over, 38 subjects were classified as obese (BMI ≥ 25) and 113 subjects were classified as overweight (23 ≤ BMI < 25). The percentile of those with a BMI of 25 kg/m2 was 70, and they had 30.82% body fat. HDL cholesterol showed a negative correlation with anthropometric factors (height howed a positive correlation. Especially, total cholesterol, LDL cholesterol, and hip circumference showed significant correlations. Because of differences in the body fat and lean body mass by age group, it seems difficult to assess obesity via BMI only. The elderly especially should have a higher significance placed on body fat or abdominal fat than only BMI.
Park, Seong-Ju,Kim, Sung Bock,Lee, El Hang,Ro, Jeong Rae,Yi, Jae-Yel,Lee, Joeng Yong,Ha, Jeong Sook,Park, Hyo Hoon 東亞大學校附設基礎科學硏究所 1997 基礎科學硏究論文集 Vol.14 No.1
Temperature-dependent evolution of surface corrugation and the interface dislocation in ?? epilayer on GaAs(100) substrate grown by chemical beam epitaxy using unprecracked monoethylarsine have been investigated by atomic force microscope(AFM) and transmission electron microscopy (TEM). AFM images showed that the line direction of surface ridge changes from [011] to [011] with increasing temperature. However, TEM micrographs showed that dislocation networks are formed along both [011] and [011] directions at the interface. These results indicate that growth kinetics on the terrace and at surface steps generated by the dislocations play an important role in determining the direction of surface corrugation. We suggest that the temperature-dependent change of surface corrugation is caused by an anisotropic surface diffusion on the terrace and different sticking probability of adsorbates on the surface steps which were produced by interface misfit dislocation along the two orthogonal surface directions.