http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Kim¸ Hyeon Gyeong ),( Jeong¸ Chang Geun ) 한국경영공학회 2023 한국경영공학회지 Vol.28 No.3
Purpose The purpose of this paper is to produce theoretical implications by presenting a response strategy to reduce turnover intention of Air Force pilots based on preceding research. Methods As such, a survey was conducted on Air Force pilots with at least 24 months of work experience under the Ministry of National Defense, 241 of which were targets of analysis. Results This paper finds that reduction in role ambiguity overload, financial job reward, and role achievement culture had a significant and positive (+) effect on job satisfaction, and power-oriented culture had a significant and negative (-) effect on job satisfaction. Conclusion Air Force pilots' working conditions were identified as a major factor of pilots' job satisfaction. This paper empirically verified operating mechanism of Air Force pilot management, and affirmed its effectiveness and validity of reward systems by verifying that job satisfaction is a partial mediator for working conditions and turnover intention.
Kim Hyojin,Yoon Yune-Jung,Kim Hyunmi,Cha Eun-Young,Lee Hye Suk,Kim Jeong-Han,Yi Kyu Yang,Lee Sunkyung,Cheon Hyae Gyeong,Yoo Sung-Eun,Lee Sang-Seop,Shin Jae-Gook,Liu Kwang-Hyeon The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.11
KR-33028 (N-[4-cyano-benzo[b]thiophene-2-carbonyl]guanidine) is a new cardioprotective agent for preventing ischemia-reperfusion injury. This study was performed to identify the metabolic pathway of KR-33028 in human liver microsomes and to compare its metabolism with that of cryopreserved human hepatocytes. Human liver microsomal incubation of KR-33028 in the presence of NADPH and UDPGA resulted in the formation of four metabolites, M1, M2, M3, and M4. M1 and M2 were identified as 5-hydroxy-KR-33028 and 7-hydroxy-KR-33028, respectively, on the basis of LC/MS/MS analysis with the synthesized authentic standard. M3 and M4 were suggested to be dihydroxy-KR-33028 and hydroxy-KR-33028-glucuronide, respectively. Metabolism of KR-33028 in cryopreserved human hepatocytes resulted in the formation of M1, M2, and M4. These data show a good correlation between major metabolites formed in human liver microsomes and cryopreserved human hepatocytes. In addition, KR33028 was found to inhibit moderately the metabolism of CYP1A2 substrates. Based on the results obtained metabolic pathway of KR-33028 is proposed.
Kim, Gyeong Taek,Seo, Bo Hyeon,Lee, Won June,Park, Jeong,Kim, Min Kuk,Lee, Sang Min Elsevier Ltd 2017 Fuel Vol.194 No.-
<P><B>Abstract</B></P> <P>The effect of applying non-thermal plasma (NTP) (by adopting a dielectric barrier discharge) to a lean premixed model gas turbine combustor on flame stability and emissions of NOx and CO has been investigated experimentally by varying mixture nozzle exit velocity (<I>U</I> <SUB>0</SUB>) and equivalence ratio ( ∅ ) . The results showed that the existence of flame enhanced streamer intensity. The streamer intensity decreased as equivalence ratio deceased. Applying NTP to the combustor extended the lean flammable limit, and augmented the flame stability in a manner that the stable flame regime was extended to lower equivalence ratio and the regimes of lifted and oscillating flames are reduced. It was also found that it resulted in increase of NOx emission slightly (however, having a maximum of 10ppm) and reduction of CO emission significantly due to exalting complete burning. Nonetheless, with applying the NTP extending the lean flammable limit for the baseline case without it, an optimal range in ∅ existed, i.e. <30ppm for CO emission and ⩽10ppm for NOx at 0.600⩽ ∅ ⩽0.650. These results suggest that applying NTP to a gas turbine combustor should be a useful tool to simultaneously reduce both emissions of NOx and CO.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Applying NTP to a model gas turbine combustor is an original work. </LI> <LI> Applying NTP extends the lean flammable limit appreciably and enhances flame stability. </LI> <LI> Some optimal flame conditions to simultaneously fulfill a stringent regulation for NOx and CO emissions under applying NTP exist. </LI> </UL> </P>
Application of fracture mechanical assessment to in-wall shield ribs in ITER vacuum vessel
Kim, Yu-Gyeong,Kim, Hyun-Soo,Park, Chul-Kyu,Kim, Gwang-Ho,Moon, Ho-Kyu,Hong, Kwen-Hee,Chung, Woo-Ho,Lee, Hyeon-Gon,Sa, Jeong-Woo,Choi, Chang-Ho,Sim, Jae-Min,Chang, Yoon-Suk North-Holland 2017 Fusion engineering and design Vol.124 No.-
<P><B>Abstract</B></P> <P>In-wall shield ribs are installed between double walls of vacuum vessel and their role is to hold neutron shielding blocks. Since one of key issues on these structures is to sustain integrity during entire ITER operation without any in-service inspection or maintenance, fracture behavior shall be evaluated in design stage. In the present study, a weight function method was employed for crack initiation assessment. The most critical structure was selected as a representative one and its structural integrity was evaluated. In order to check validity of this method, an extended finite element method was adopted for bounding cases. As a result, not only structural safety but also quite conservatism were observed comparing to those of extended finite element analysis with similar tendency. It means that the weight function method could be a conservatively practical approach for fracture mechanical assessment of in-wall shield ribs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Structural analysis of IWS rib assembly was performed and verified via RCC-MR. </LI> <LI> Systematic crack initiation assessment was conducted by using weight function method. </LI> <LI> Conservatism of the weight function method was verified by detailed X-FEM analyses. </LI> </UL> </P>
Kim, Jin-A,Park, Hyeon-Soo,Park, Kwang-Il,Hong, Gyeong-Eun,Nagappan, Arulkumar,Zhang, Jue,Han, Dae-Yong,Shin, Sung-Chul,Won, Chung-Gil,Kim, Eun-Hee,Kim, Gon-Sup Institute for Advanced Research in Asian Science a 2013 The American journal of Chinese medicine Vol.41 No.4
<P>Skeletal muscle is an important organ in our body and a dynamic composite of proteins. Citrus aurantium L. has been widely used in oriental medicine in Eastern Asia for a long time. It contains over 100 bioactive compounds and flavonoids that regulate the inflammatory response and tumorigenesis, through various mechanisms. In the present study, we investigated changes in the protein pattern using two-dimensional electrophoresis (2-DE) and matrix assisted laser desorption ionization time of flight mass spectroscopy (MALDI-TOF/MS) to assess the anti-inflammatory effect of flavonoids isolated from Korean C. aurantium L. in lipopolysaccharide (LPS)-induced L6 cells. L6 skeletal muscle cells were pretreated with flavonoids for 1 h and stimulated with LPS for 24 h. Proteins from the L6 cells of the control, LPS treated and flavonoid treated groups were extracted and resolved by 2-DE using pH 4-7 IPG strips loaded with 150 μg of protein. Forty-one differentially expressed protein spots were identified (more than two-fold was considered significant, p < 0.05), and 18 were detected by MALDI-TOF/MS. These results suggest that proteomics can be used to identify changes in the expression of marker proteins and the anti-inflammatory effect of flavonoids isolated from Korean C. aurantium L.</P>
Acute Stress Responsive RGS Proteins in the Mouse Brain
Kim, Gyeong-Wha,Lee, Young-Hyurk,Jeong, Eun-Young,Jung, Soon-Woong,Son, Hyeon-Wi,Lee, Dong-Hoon,Roh, Gu-Seob,Kang, Sang-Soo,Cho, Gyeong-Jae,Choi, Wan-Sung,Kim, Hyun-Joon Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.2
Regulator of G-protein signaling (RGS) proteins play an important role in G-protein coupled receptor (GPCR) signaling and the activity of some GPCRs is modulated via RGS protein levels during stress response. The aim of this study was to investigate changes in RGS protein mRNA expressions in the mouse brain after 2h restraint stress. The mRNA level of 19 RGS proteins was analyzed using real-time PCR in six brain regions, which included the prefrontal cortex, amygdala, hippocampus, hypothalamus, striatum, and pituitary gland, from control and stressed mouse. We found that the level of mRNA of each RGS varied according to brain region and that two to eight RGS proteins exhibited changes in mRNA levels in each brain region by restraint stress. It was also revealed that RGS4 protein amount was consistent with mRNA level, indicating RGS4 protein may have regulatory roles in the acute stress response.
Kim, In-Suk,Kim, Hoon-Gu,Kim, Dong Chul,Eom, Hyeon-Seok,Kong, Sun-Young,Shin, Ho-Jin,Hwang, Sang-Hyun,Lee, Eun-Yup,Lee, Gyeong-Won Wiley (Blackwell Publishing) 2008 CANCER SCIENCE Vol.99 No.12
<P>ATP-binding cassette transporter G2 (ABCG2) is the most recently described transporter of the multidrug-resistance pump and it promotes resistance to anticancer drugs such as doxorubicin, mitoxantrone, topotecan, and SN-38. Of the ABCG2 polymorphisms, V12M and Q141K alter the functional activity of the ABCG2 transporter and influence the drug response and various toxicities to chemotherapeutic agents. We therefore evaluated the impact of the ABCG2 V12M and Q141K polymorphisms on the therapeutic outcomes and toxicities of primary rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone (R-CHOP) therapy in 145 Korean patients with diffuse large B-cell lymphoma (DLBCL). ABCG2 V12M and Q141K genotyping was carried out by pyrosequencing of polymerase chain reaction products. The clinical characteristics, treatment outcomes, toxicities of the patients, and the predictive value of the polymorphisms on response, survival, and adverse events to R-CHOP for 145 patients were analyzed according to the ABCG2 V12M and Q141K polymorphisms. No differences were observed according to ABCG2 Q141K and V12M genotype in patient characteristics, disease characteristics, response, survival, or hematology toxicity profiles in patients with DLBCL who received frontline R-CHOP chemotherapy. On multivariate analysis, grade I-IV diarrhea was statistically significant according to ABCG2 Q141K polymorphism (the QQ genotype vs the QK or KK genotypes; hazard ratio 2.835; 95% confidence interval 1.432-5.613; P = 0.003). This study demonstrates that the ABCG2 Q141K polymorphism may correlate with chemotherapy-induced diarrhea in patients with DLBCL who have received frontline R-CHOP chemotherapy, and this has implications for optimizing treatment with such agents.</P>