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- 저자 : Kim Hoe Suk (검색결과 345 건)
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한국산 시궁쥐(Rattus norvegicus)와 곰쥐(Rattus rattus)의 mtDNA RFLPs
김회숙,유선아,백상기,김영진 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2
RFLPs(restriction fragment length polymorphisms) of mitochondrial DNA(mtDNA) of Rattus norvegicus and Rattus rattus in Korea were observed. All of the mtDNA of R. norvegicus individuals were shown no variatioin by the single digestion with EcoR Ⅰ, Hind Ⅲ, Ksp Ⅰ, Hind Ⅱ and Cfo Ⅰ as well as the double digestion with BamH Ⅰ/Sac Ⅰ or Hpa Ⅰ/Xba Ⅰ. Morph-1(18.75%) and morph-2(81.25%)) were observed by digestion with Hind Ⅱ in mtDNA of R. norvegicus. Morph-1(91.70%) and morph-2(8.30%) were observed by digestion with Cfo Ⅰ in mtDNA of R. norvegicus. In the mtDNA obtained from 3 R. rattus individuals, no variants were observed. The types of mtDNA obtained from 48 R. norvegicus individuals were four types(RN 1, RN 2, RN 3 and RN 4). The frequency of RN 1, RN 2, RN 3 and RN 4 was 66.67%, 14.58%, 6.25% and 12.50%, respectively. The value range of nucleotide diversity in mtDNA of R. norvegicus was between 0.0059 and 0.0153, and the value of nucleotide diversity of mtDNA between R. norvegicus and R. rattus was 0.13. The divergence time between the two species is believed to be 6.5 million years ago.
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조백현,김영길,허우회,최석현 大韓成形外科學會 1983 Archives of Plastic Surgery Vol.10 No.2
The purpose of this study was to investigate the sequential changes of enzyme activities in severely burned skin of rat at intervals of 2 hours, 8 hours, 1 day and 3 days by histochemical methods. The results obtained were as follows. 1. Acid phosphatase activity was found to be transient increase in dermis and mild decrease in epidermis, hair follicle and sebaceous gland at 2 hour after burning. The activity was not seen in skin after 8 hours. 2. Alkaline phosphatase was found to be decreased in blood vessel and dermal papillae of hair follicle at 2 hour after burning and then was progressively decreased after 8 hours. 3.α-naphtyl acetate esterase activity was found to be decreased in epidermis, dermis and hair follicle at 2 hours after burning and was not seen in skin after 8 hours. There was no significant changes in sebaceous gland after burning.
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Collateral status affects the onset-to-reperfusion time window for good outcome
Kim, Byung Moon,Baek, Jang-Hyun,Heo, Ji Hoe,Nam, Hyo Suk,Kim, Young Dae,Yoo, Joonsang,Kim, Dong Joon,Jeon, Pyoung,Baik, Seung Kug,Suh, Sang Hyun,Lee, Kyung Yol,Kwak, Hyo Sung,Roh, Hong Gee,Lee, Young- British Medical Association 2018 Journal of neurology, neurosurgery and psychiatry Vol.89 No.9
<P>Conclusions Earlier successful recanalisation was strongly associated with good outcome in poor collateral group; however, this association was weak during the tested time window in good collateral group. This suggests that the ORT window for good outcome can be adjusted according to collateral status.</P>
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Brachial-Ankle Pulse Wave Velocity for Predicting Functional Outcome in Acute Stroke
Kim, Jinkwon,Song, Tae-Jin,Kim, Eun Hye,Lee, Ki Jeong,Lee, Hye Sun,Nam, Chung Mo,Song, Dongbeom,Nam, Hyo Suk,Kim, Young Dae,Heo, Ji Hoe American Heart Association, Inc. 2014 Stroke Vol.45 No.8
<P><B>Background and Purpose—</B></P><P>We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes.</P><P><B>Methods—</B></P><P>We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Poor functional outcomes were defined as modified Rankin Scale score >2 at 3 months after stroke onset.</P><P><B>Results—</B></P><P>We noted that 181 (16.59%) patients had a poor functional outcome. In multivariate logistic regression, patients in the highest tertile of baPWV (>22.25 m/s) were found to be at increased risk for poor functional outcome (adjusted odds ratio, 1.88; 95% confidence interval, 1.06–3.40) compared with those in the lowest tertile (<17.55 m/s). No significant interaction between baPWV and stroke subtype was noted. Receiver operating characteristic curve analysis indicated that the addition of baPWV to the prediction model significantly improved the discrimination ability for poor functional outcome.</P><P><B>Conclusions—</B></P><P>baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.</P>
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Kim, Young Dae,Song, Dongbeom,Nam, Hyo Suk,Choi, Donghoon,Kim, Jung-Sun,Kim, Byeong-Keuk,Chang, Hyuk-Jae,Choi, Hye-Yeon,Lee, Kijeong,Yoo, Joonsang,Lee, Hye Sun,Nam, Chung Mo,Heo, Ji Hoe Yonsei University, College of Medicine 2017 Yonsei medical journal Vol.58 No.1
<P><B>Purpose</B></P><P>Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not.</P><P><B>Materials and Methods</B></P><P>This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (−) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses.</P><P><B>Results</B></P><P>During the mean follow-up of 38.0±24.8 months, 486 (15.6%) patients died, recurrent stroke occurred in 297 (9.5%), and cardiovascular events occurred in 60 patients (1.9%). Mean annual risks of death (9.34% vs. 2.47%), cardiovascular events (1.2% vs. 0.29%), and recurrent stroke (4.7% vs. 2.56%) were higher in the MDCT (−) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (−) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95% confidence interval 1.172–8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (−) group seemed to also have a higher risk of recurrent stroke.</P><P><B>Conclusion</B></P><P>Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.</P>
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Kim, A-Ram,Park, Tae Jung,Kim, Minseok S.,Kim, In-Ho,Kim, Ki-Suk,Chung, Kwang Hoe,Ko, Sungho Elsevier 2017 Analytica chimica acta Vol.967 No.-
<P><B>Abstract</B></P> <P>A highly sensitive electrochemical immunosensor was developed by preventing electrode fouling and using a novel fusion protein of silica binding polypeptides (SBP)-protein G (ProG) created by recombinant DNA technology as a functional crosslinker for rapid and self-oriented immobilization of antibodies onto silica nanoparticles (SiNPs). Antibody immobilization onto the SiNPs by the SBP-ProG could rapidly be achieved without any chemical treatment. The immunosensor was fabricated through bonding of a partially gold-deposited cyclic olefin copolymer (COC) (top substrate) and gold patterned interdigitated array COC electrode (bottom substrate). To prevent electrode fouling, human immunoglobulin G (hIgG) was immobilized onto the ceiling inside the microchannel, instead of the bottom electrode. Alkaline phosphatase (AP)-labeled anti-hIgG was allowed to immunoreact with hIgG on the ceiling, followed by addition of an enzyme to generate an oxidative peak current. A three-fold increase in current was observed from the immunosensor without any electrode fouling compared with a control with the protein functionalized electrode. Also, the SiNPs facilely coated with AP-anti-hIgG via the SBP-ProG could increase the electrochemical signal up to 20% larger than that of the AP-anti-hIgG alone. Furthermore, this immunosensor was ultrasensitive with a detection limit of 0.68 pg/mL of a biomarker associated with prostate cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel fusion protein was developed as crosslinker for rapid self-oriented immobilization of antibody on SiNPs. </LI> <LI> This crosslinker contributed to easy formation of SiNPs/Ab complexes, resulting in electrochemical signal enhancement. </LI> <LI> Novel prevention method of electrode fouling was developed to enhance sensitivity of the electrochemical immunosensor. </LI> <LI> This immunosensor exhibited excellent sensitivity with the simple fabrication methods. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke
Kim, Jinkwon,Song, Tae-Jin,Song, Dongbeom,Lee, Ki Jeong,Kim, Eun Hye,Lee, Hye Sun,Nam, Chung Mo,Nam, Hyo Suk,Kim, Young Dae,Heo, Ji Hoe American Heart Association, Inc. 2014 Hypertension Vol.64 No.2
<P>Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is unknown. We evaluated the prognostic value of baPWV in 1765 patients who had been admitted for acute ischemic stroke and had completed measurement of baPWV during admission. Primary outcomes were all-cause mortality and vascular mortality (death because of heart diseases, cerebrovascular diseases, or diseases of arteries, arterioles, and capillaries, determined according to the <I>International Classification of Diseases</I>) after stroke. During a mean follow-up period of 3.33±1.57 years, there were 228 all-cause deaths, including 143 vascular deaths. In multivariate Cox hazard regression, patients in the highest tertile of baPWV (>22.63 m/s) were at an increased risk for both all-cause death (adjusted hazard ratio, 1.97; 95% confidence interval, 1.25–3.08) and vascular death (adjusted hazard ratio, 2.39; 95% confidence interval, 1.33–4.29) compared with the lowest tertile (<17.79 m/s). This study suggested that measurement of baPWV during the acute phase of stroke might be useful in identifying patients at a higher risk for mortality.</P>
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Anatase TiO2 nanorod-decoration for highly efficient photoenergy conversion.
Kim, Dong Hoe,Seong, Won Mo,Park, Ik Jae,Yoo, Eun-Sang,Shin, Seong Sik,Kim, Ju Seong,Jung, Hyun Suk,Lee, Sangwook,Hong, Kug Sun RSC Pub 2013 Nanoscale Vol.5 No.23
<P>In recent studies of inorganic materials for energy applications, surface modification processes have been shown to be among the most effective methods to enhance the performance of devices. Here, we demonstrate a facile nano-decoration method which is generally applicable to anatase TiO2 nanostructures, as well as a nano-decorated hierarchical TiO2 nanostructure which improves the energy conversion efficiency of a dye-sensitized solar cell (DSSC). Using a facile sol-gel method, 0-D, 1-D, and 2-D type anatase TiO2 nanostructures were decorated with 200 nm long anatase TiO2 nanorods to create various hierarchical nanostructures. A structural analysis reveals that the branched nanorod has a highly crystalline anatase phase with anisotropic growth in the [001] longitudinal direction. When one of the hierarchical structures, a chestnut bur-like nanostructure, was employed in a dye-sensitized solar cell as a scattering layer, offering increased dye-loading properties, preserving a sufficient level of light-scattering ability and preserving superior charge transport and recombination properties as well, the energy conversion efficiency of the cell improved by 19% (from 7.16% to 9.09%) compared to a cell with a 0-D TiO2 sphere as a scattering layer. This generally applicable anatase nanorod-decorating method offers potential applications in various energy-conversion applications, especially in DSSCs, quantum-dot solar cells, photoelectrochemical water-splitting devices, photocatalysis, and lithium ion batteries.</P>
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