학동기 비만아동의 피부두께의 통계적 관찰

김경석,나기찬,정은경,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

The measurements of triceps skinfold thickness, body weight and height were done in children aged 7 to 12 years(3,142 boys and 2588 girls) in Kwangju in 1992. The author also observed degree of obesity, prevalence of obesity and average value of triceps skinfold thickness. The results were summarized as follows: 1) The mean value of triceps skinfold thickness acceding to age in male was 7 years 10.5mm, 8 years 10.5mm, 9 years 10.2mm, 10 years 12.3mm, 11 years 13.8mm, 12 years 12.3mm. In the female it was 7 years 11.9mm, 8 years 11.9mm, 9 years 11.6mm, 10 years 12.6mm, 11 years 14.1mm, 12 years 13.6mm. 2) The mean value of triceps skinfold thickness acceding to age in obese male was 7 years 16.3mm, 8 years 17.3mm, 9 years 16.0mm, 10 years 19.5mm, 11 years 23.7mm, 12 years 20.1mm. In the obese female it was 7 years 17.3mm, 8 years 17.9mm, 9 years 18.4mm, 10 years 19.5mm, 11 years 21.2mm, 12 years 20.3mm.

지식기반사회의 학교 교육과정 개발을 위한 7차 초등 국어 교과서 분석

김경자,유솔아,유은경 이화여자대학교 교육과학연구소 2001 교육과학연구 Vol.32 No.1

이 연구는 지식기반 사회에서의 학교 교육과정 개발을 위한 선행 연구로서, 국가 수준에서 개발된 7차 초등 국어와 교육과정이 초등 국어 교과서로 '어떻게', '얼마나' 잘 녹아들어 있는가를 분석하는 데 목적이 있다.특히, 학습자 중심 교수-학습의 일환으로, 현 7차 교육과정이 새롭게 시도한 수준별교육과정이 실제 초등 교과서에 어떻게 구현되고 있는가를 살펴보았다.이를 위해 먼저, 국가 고시 교육과정 문서의 교육 목표, 교육 내용, 교육 방법, 교육 평가 부분을 살펴보고, 이에 근거하여 교과서에의 반영 정도를 분석하였다.교과서 분석은 크게 '구성과 제시형식 분석'과 '내용 분석'으로 나뉘고, 내용 분석은 다시 목표, 내용, 방법, 평가로 나뉘어 전개되었다.분석결과, 교육과정 문서상의 목표와 내용은 교과서로 번역되는 과정에서 단편적이고 분절된 활동이나 사례들로 제시되고 있어, 교육과정과 교과서간의 연계성에 더 주의를 기울일 필요가 있음이 드러났다.방법적인 측면에 있어서도 교육과정 문서가 표방한 '자기주도적 학습'에 부합되지 않는 방식으로 교과서가 전개되는 경향이있고, 평가 부분에 대한 반영도 미흡한 것으로 나타났다.또한 7차 교육과정이 의도한 심화ㆍ보충형 수준별 교육과정은 외견상으로 교과서에 반영된 듯 보이나 실질적으로는 개인차를 반영한 것이라고 평가하기 어려운 것으로 나타났다. The purpose of this study was to analyze the Koream Language Arts Textbooks for the 3rd graders developed in accordance with the 7th national curriculum.The analysis was proceeded focused on the following.(1) whether the consistency between the textbooks and the national curriculum exits in terms of goals and objectives, content, learning activities, and evaluation; (2) whether the textbooks are relevantly reflected the idea of the differentiated curriculum newly adopted in the 7th national amended curriculum. The major findings were as follows.(1) The textbooks for speaking/listening, reading, and writing were separately developed.Considering the goals and objectives of the Korean Language Arts curriculum such as creative ability, the relevance of separating the textbooks need to be discussed in the future amendation for the national curriculum.(2) The idea of the differentiated curriculum was reflected on the organization of the textbooks in a superficial way.The idea was reflected in ways of piecing the contents into pieces and have the students repeat the same pieces.

고점성 바이오유의 미립화를 위한 초음파의 적용

주은선,나우정,김종천 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

An experiment was conducted to figure out the atomization characteristics of rice-bran oil which is a highly viscous liquid by applying ultrasonic energy to improve the atomization of spray droplets. A spray simulator, an ultrasonic system, and six different nozzles(three kinds of single hole-type nozzles and three kinds of pintle-type nozzles) were made. To investigate the effects of ultrasonic energy on the atomization of a highly viscous liquid, a phase doppler particle analyzer was used for measurement and calculation of spray droplets data. Nozzle opening pressures chosen were of 5 levels, i. e., 10 MPa, 13 MPa, 16 MPa, 20 MPa, and 24 MPa. It was observed that the application of ultrasonic energy into the highly viscous rice-bran oil was effective for the atomization improvement of the liquid fuel. With the increase of nozzle opening pressures and pin-edge angles, and with the decrease of the hole diameters, the atomization of spray droplets was improved, which conforms to general theoretical characteristics.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

Kim, Eun Kyung,Lee, Seung Hoon,Jhun, Joo Yeon,Byun, Jae Kyeong,Jeong, Jeong Hee,Lee, Seon-Young,Kim, Jae Kyung,Choi, Jong Young,Cho, Mi-La Hindawi Publishing Corporation 2016 MEDIATORS OF INFLAMMATION Vol.2016 No.-

<P>Obesity and its associated metabolic disorders are related to the onset of fatty liver and the balance of white adipose tissue (WAT) and brown adipose tissue (BAT). We hypothesized that metformin, an effective pharmacological treatment for type 2 diabetes, would inhibit white adipogenesis, fatty liver, and metabolic dysfunction. Metformin was treated daily for 14 weeks in a high-fat dieting C57BL/6J mice. Serum biomarkers were analyzed and protein level was assessed using confocal staining or flow cytometry. The development of lipid drops in the liver cells and white adipocyte was measured using hematoxylin and eosin or Oil Red O stains. Gene expressions were analyzed with quantitative real-time PCR. Metformin treatment decreased the body weight and improved the metabolic profile of obese mice. In obese mice, metformin also induced the expression of BAT-related markers and increased fibroblast growth factor (FGF) 21 expression in the liver and in white adipocyte. Metformin suppressed white adipocyte differentiation via induction of FGF21. Metformin improves Treg/Th17 balance in CD4+ T cells in mice with high-fat diet-induced obesity. Metformin also improves glucose metabolism and metabolic disorder. Interleukin-17 deficiency also decreases inflammation in mice. Therefore, metformin may be therapeutically useful for the treatment of obesity and metabolic dysfunction. </P>

Prevalence of the <i>CTNNB1</i> mutation genotype in surgically resected fibromatosis of the breast

Kim, Taeeun,Jung, Eun Ah,Song, Ji Young,Roh, Ji Hyeon,Choi, Jong Sun,Kwon, Jee Eun,Kang, So Young,Cho, Eun Yoon,Shin, Jung Hee,Nam, Suk‐,Jin,Yang, Jung Hyun,Choi, Yoon‐,La Blackwell Publishing Ltd 2012 Histopathology Vol.60 No.2

<P>Kim T, Jung E A, Song J Y, Roh J H, Choi J S, Kwon J E, Kang S Y, Cho E Y, Shin J H, Nam S‐J, Yang J H & Choi Y‐L 
(2012) <I>Histopathology</I>?<B>60,</B> 347–356 
<B>Prevalence of the <I>CTNNB1</I> mutation genotype in surgically resected fibromatosis of the breast</B></P><P><B>Aims: </B> To investigate <I>CTNNB1</I> mutation and β‐catenin expression in resected breast fibromatosis and to identify potential molecular markers of fibromatosis of the breast.</P><P><B>Methods and results: </B> We selected 12 patients with fibromatosis of the breast who underwent surgical resection and were confirmed by histological examination. Ultrasonography findings for 10 patients were reviewed and only two cases were suspicious for fibromatosis on imaging. On core needle biopsy for pre‐operative diagnoses, only three cases were histologically suspicious for fibromatosis. Mutations in exon 3 of <I>CTNNB1</I> were detected by direct DNA sequencing in nine (75.0%) cases: all were c.121G>A (p.T41A), which was much more frequent in breast fibromatoses than in other soft tissue lesions. Nuclear β‐catenin expression was observed in all cases and the level of expression was higher in cases with mutation. In eight of nine cases, the matched biopsy specimen showed the same <I>CTNNB1</I> mutation status as the pre‐operative specimen.</P><P><B>Conclusions: </B> In the majority of cases, clinical presentation and breast imaging are highly suspicious for carcinoma. Definitive pre‐operative pathological diagnosis by core needle biopsy is difficult. <I>CTNNB1</I> mutation and nuclear β‐catenin expression are frequently detected in sporadic breast fibromatoses, suggesting their potential as a useful tool to distinguish breast fibromatoses from other neoplasms.</P>

Chemical fingerprint analysis of fermented Morinda citrifolia L. (Noni) juice by UHPLC Q-TOF/MS combined with chemometric analysis

Kim Yoonjeong,Pyeon Jiye,Lee Jae-Yeon,Kim Eun-Min,La Im-Joung,Lee Ok-Hwan,Kim Keono,Sung Jeehye,Kim Younghwa 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-

Morinda citrifolia L. (Noni) has been widely used in traditional medicine in tropical zones and has become increasingly popular globally owing to its health benefits. Most noni fruits are consumed as juice, which is traditionally produced by the natural fermentation of noni fruits. In this study, the metabolic profiles of noni fruit juice (NJ1) and fermented noni fruit juices (NJ2 and NJ3) was compared. A total of 74, 83, and 91 compounds including anthraquinones, coumarins, flavonoids, phenolic acids, phenolics, terpenoids, and miscellaneous (acids, carbohydrates, vitamins, fatty acids, etc.) were tentatively identified from NJ1, NJ2, and NJ3 in both positive and negative electrospray ionization modes. The phenolic compound composition differed significantly between noni juice and fermented noni juice. The results of the unsupervised principal component analysis and hierarchical clustering analysis showed that the non-fermented juice group clustered with the fermented juice groups. Asperulosidic acid, isoasperulosidic acid, and rutin levels were higher in the NJ1 group than those in the NJ2 group. Deacetylasperulosidic acid and monotropein contents in NJ2 were higher than those in NJ1. Similarly, NJ1 had higher asperulosidic acid and isoasperulosidic acid than those in NJ3. The findings from this study have the potential to enhance the quality of fermented noni juice. Morinda citrifolia L. (Noni) has been widely used in traditional medicine in tropical zones and has become increasingly popular globally owing to its health benefits. Most noni fruits are consumed as juice, which is traditionally produced by the natural fermentation of noni fruits. In this study, the metabolic profiles of noni fruit juice (NJ1) and fermented noni fruit juices (NJ2 and NJ3) was compared. A total of 74, 83, and 91 compounds including anthraquinones, coumarins, flavonoids, phenolic acids, phenolics, terpenoids, and miscellaneous (acids, carbohydrates, vitamins, fatty acids, etc.) were tentatively identified from NJ1, NJ2, and NJ3 in both positive and negative electrospray ionization modes. The phenolic compound composition differed significantly between noni juice and fermented noni juice. The results of the unsupervised principal component analysis and hierarchical clustering analysis showed that the non-fermented juice group clustered with the fermented juice groups. Asperulosidic acid, isoasperulosidic acid, and rutin levels were higher in the NJ1 group than those in the NJ2 group. Deacetylasperulosidic acid and monotropein contents in NJ2 were higher than those in NJ1. Similarly, NJ1 had higher asperulosidic acid and isoasperulosidic acid than those in NJ3. The findings from this study have the potential to enhance the quality of fermented noni juice.

Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis

Kim, Geun-Tae,Cho, Mi-La,Park, Young-Eun,Yoo, Wan Hee,Kim, Jung-Hee,Oh, Hye-Jwa,Kim, Dae-Sung,Baek, Seung-Hoon,Lee, Sun-Hee,Lee, Jun-Hee,Kim, Ho-Youn,Kim, Sung-Il Springer-Verlag 2010 CLINICAL RHEUMATOLOGY Vol.29 No.3

<P>The aim of this study was to investigate the expressions of Toll-like receptor (TLR) 2, TLR4, TLR9, and their correlations with the expression of cytokines that are associated with activation of CD4<SUP>+</SUP> T cells and inflammation including interferon γ (IFNγ), interleukin 4 (IL4), interleukin 17 (IL17), and tumor necrosis factor α (TNFα) in muscle tissues of patients with dermatomyositis (DM) and polymyositis (PM). The expressions of TLR2, TLR4, TLR9, IFNγ, IL4, IL17, and TNFα were measured by real-time reverse transcription–polymerase chain reaction in muscle tissues from 14 patients with DM and PM (nine patients with DM, five patients with PM) and three controls. The expressions of TLR2, TLR4, and TLR9 were also localized with immunohistochemistry. The expression levels of TLR2, TLR4, TLR9, IFNγ, IL4, IL17, and TNFα were significantly high in patients with DM and PM compared with those in the controls, and the expression levels of TLR4 and TLR9 had significant positive correlations with the expressions of IFNγ, IL4, IL17, and TNFα. Immunohistochemistry showed that TLR2, TLR4, and TLR9 were expressed by infiltrating cells of perimysium in DM, whereas they were expressed by infiltrating cells of endomysium in PM. These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4<SUP>+</SUP> T cells.</P>

New Rancinamycin Analogues from Streptomyces lincolnensis

Kim, Mi-Ae,Kim, Eun-La,Kim, Kyoung-Ja,Hong, Jong-Ki,Bao, Baoquan,Jung, Jee-H. Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.6