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Tae-Jun Kwon,Da-Sol Lee,Md. Enamul Haque,Rang-Woon Park,Byungheon Lee,Dongkyu Kim,Yong-Hyun Jeon,Kil-Soo Kim,Sang Kyoon Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
The development of reliable methods to diagnose acute kidney injury is essential to allow the adoption of early therapeutic interventions and evaluate their effectiveness. Based on the fact that kidney injury molecule-1 (KIM-1) expression levels in kidneys are markedly upregulated early after a damage event, here we developed a noninvasive KIM- 1-based molecular imaging technique to detect kidney injury. First, we took advantage of a phage-display platform to select small peptides demonstrating a specific high binding affinity to KIM-1. The promising candidate was conjugated with fluorescent probes, and its imaging potential was validated in vitro and in vivo. This peptide, with the sequence CNRRRA, not only showed a high imaging potential in vitro, allowing a strong detection of KIM-1 expressing cells by microscopy and flow cytometry but also generated a strong kidney-specific signal in live-imaging in vivo experiments in the context of a drug-induced kidney-injury mouse model. Our data overall suggest that the CNRRRA peptide is a promising probe to use in the context of in vivo imaging for the detection of KIM-1 overexpression in damaged kidneys.
Intracranial Tumors Associated With IgG4-Related Disease
( Dongkyu Kim ),( Se Hoon Kim ),( Eui Hyun Kim ) 대한뇌종양학회 대한신경종양학회 2021 Brain Tumor Research and Treatment Vol.9 No.2
IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory condition which is characterized by dense lymphoplasmacytic infiltrations with a predominance of IgG4 plasma cells in the affected tissue. Although pachymeninx and pituitary gland are the most common sites where IgG4-RD infiltrates, the associations with IgG4-RD and a true intracranial tumor have not been yet reported in literature. Herein, we report two cases with intracranial tumors associated with IgG4-RD; a 36-year-old male patient with a huge meningioma and another 54-year old woman with a pituitary macroadenoma. Pathological examination revealed their tumors were substantially infiltrated by IgG4 plasma cells indicating its possible relation with IgG4-RD.
Kim, Hyosuk,Kim, Dongkyu,Ku, Sook Hee,Kim, Kwangmeyung,Kim, Sun Hwa,Kwon, Ick Chan Informa UK (TaylorFrancis) 2017 Journal of Biomaterials Science. Polymer Edition Vol. No.
<P>Technological advances opened up new ways of directing cell fate conversion from one cell lineage to another. The direct cell conversion technique has recently attracted much attention in regenerative medicine to treat devastated organs and tissues, particularly having limited regenerative capacity such as the heart and brain. Unfortunately, its clinical application is severely limited due to a safety concern and immunogenicity of viral vectors, as human gene therapy did in the beginning stages. In this study, we examined the possibility of adopting non-viral vectors to direct cell conversion from mouse embryonic fibroblasts to induced cardiomyocytes (iCM) by transient transfection of four types of chemically synthesized microRNA mimics (miRNA-1, 133, 208, and 499). Herein, we tested several commercial and synthetic non-viral gene delivery carriers, which could be divided into three different categories: polymers [branched PEI (bPEI), bioreducible PEI (PEI-SS), deoxycholic acid-conjugated PEI (DAPEI), jetPEI T, SuperFect T], lipids (Lipofectamine 2000 T), and peptides (PepMute T). According to the analyses of physicochemical properties, cellular uptake, and cytotoxicity of the carrier/miRNA complexes, DAPEI exhibited excellent miRNA delivery efficiency to mouse embryonic fibroblasts. One week after a single treatment of DA-PEI/miRNA without other adjuvants, the cells started to express cardiomyocyte-specific markers, such as alpha-actinin and alpha-MHC, indicating the formation of cardiomyocyte-like cells. Although the overall frequency of non-viral vector induced cardiomyogenic transdifferentiation was quite low (ca. 0.2%), this study can provide compelling support to develop clinically applicable transdifferentiation techniques.</P>
터보차져를 이용한 연료전지 시스템의 효율 향상에 대한 수치 해석적 연구
김동규(Dongkyu Kim),서정훈(Jeonghoon Seo),김선엽(Seonyeob Kim),송한호(Hanho Song),김민수(Minsoo Kim) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5
Parasitic power is a crucial factor in determining the total efficiency for pressurized fuel cell system. Generally, pressure is applied through compressor which consumes high power. This paper suggest novel system using turbocharger that has benefit in reducing compressor power. In order to investigate performance of this novel fuel cell system, steady state model of PEMFC system is developed adding turbocharger. The model is discretized into several part ? stack, membrane humidifier, compressor, thermal management system and extra device ? to resolve performance enhancement of the system. At first, the performance of simulation of general pressurized PEMFC system is analyzed in each model and whole integrated system. After that, novel system with turbocharger is analyzed in same process of that of general system. Finally, relations among whole parts are considered under various operating conditions. These results are useful to design the variable pressure PEMFC system model with turbocharger and find optimal operating condition under various current densities.
Lee, Dongkyu,Kim, Dowon,Kim, Youngwoong,Park, Ki-hyun,Oh, Eun-Jee,Kim, Yonggoo,Kim, Byungkyu SAGE Publications 2014 Journal of laboratory automation Vol.19 No.1
<P>We present a negative dielectrophoresis (n-DEP)–based cell separation system for high-throughput and high-efficiency cell separation. To achieve a high throughput, the proposed system comprises macro-sized channel and cantilever-type electrode (CE) arrays (L × W × H = 150 µm × 500 µm × 50 µm) to generate n-DEP force. For high efficiency, double separation modules, which have macro-sized channels and CE arrays in each separation module, are employed. In addition, flow regulators to precisely control the hydrodynamic force are allocated for each outlet. Because the hydrodynamic force and the n-DEP force acting on the target cell are the main determinants of the separation efficiency, we evaluate the theoretical amount of hydrodynamic force and n-DEP force acting on each target cell. Based on theoretical results, separation conditions are experimentally investigated. Finally, to demonstrate the separation performance, we performed the separation of target cells (live K562) from nontarget cells (dead K562) under conditions of low voltage (7Vp-p with 100 kHz) and a flow rate of 15 µL•min<SUP>−1</SUP>, 6 µL•min<SUP>−1</SUP>, and 8 µL•min<SUP>−1</SUP> in outlets 1, 2, and 3, respectively. The system can separate target cells with 95% separation efficiency in the case of the ratio of 5:1 (live K562:dead K562).</P>
Evaluation of in vivo biodistribution using fluorescent probe labeled microplastic
Dongseon Kim,Hee-Kyung Kim,Dongkyu Kim,Tae-Jun Kwon,Chang-Hoon Shin,Kyungrim Yi,Jong-Wook Lee,Young-Eun Lee,Kil-Soo Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Recent studies have shown that microplastics contaminate our food chain and accumulate in the intestines, liver, kidney, muscles, and more. Among them, polyethylene (PE) accounts for a large proportion of microplastics found in domestic fish and shellfish. It is necessary to study for the organs where the plastics were accumulated, and whether it affects the organism by inducing various responses such as oxidative stress. Therefore, form a part of this purpose, the study is performed to observe and evaluate the microplastic accumulation in organs by in vivo fluorescence imaging. We investigated the biodistribution analysis of microplastic particles by using PEs to classify two particle sizes (5μm, 50μm). For fluorescence imaging, PEs were labeled with cyanine5.5 carboxylic acid (Cy5.5), a near-infrared fluorescent dye. The labeled PEs were characterized by DLS, TGA/DSC, and in vitro IVIS spectrum CT (Perkin elmer, USA). To in vivo biodistribution imaging, each of labeled PEs was administered to ICR mice (n=5) as tracking markers, and the images were obtained by using IVIS spectrum CT (excitation 675 nm/emission 720 nm) at each time points. Mean fluorescence intensity graphs were analyzed by region of interests (ROI) that showed the Cy5.5 labeled PEs were gradually released through the stomach over 24 h after administration. In addition to in vivo imaging and ex vivo imaging were also performed after 24 h imaging, and the fluorescence of each organs were observed. However, there was no difference in organ distribution or secretion depending on the size of microplastics and the sex of mice. In this study, the in vivo biodistribution of the Cy5.5 labeled PEs were realized by fluorescent imaging using signal intensity profiles. In future studies, various microplastics and fluorescent probes would be utilized for comparison purpose.
고분자 전해질 막 연료전지에 적용된 ORC의 효율에 대한 해석적 연구
김동규(Dongkyu Kim),김선엽(Seonyeob Kim),류진우(Jinwoo Yoo),신동규(Dongkyu Shin),고재선(Jaeseon Ko),송한호(Han Ho Song),김민수(Min Soo Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
In order to enhance efficiency of system, many researcher have been studied for reusing wasted heat from system. Several combined systems, such as combined heat and power plant, geothermal ORC system and solar ORC system, have been developed. This paper suggest novel power plant combined polymer electrolyte membrane fuel cell(PEMFC) and organic rankine cycle(ORC). At first, normal PEMFC system model is develpoed which include fuel providing system, air providing system and thermal management system. And then, TMS part is revised to introduce ORC. After proper coolant and capacity is selected for ORC, efficiency of ORC is analyzed. Lastly, influences to PEMFC are also studied.
공기극의 조건의 변화가 막가습기를 포함한 고분자 전해질막 연료전지내의 물 함량에 미치는 영향에 대한 해석적 연구
김동규(Dongkyu Kim),서정훈(Jeonghoon Seo),김선엽(Seonyeob Kim),송한호(Hanho Song),김민수(Minsoo Kim) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11
Polymer Electrode Membrane Fuel Cell s(PEMFCs) are largely used in vehicle such as automobile for high responsibility and high energy density. According to necessity of miniaturization of automobile, fuel cell systems operating in high pressure are used in these days. In order to reach high efficiency membrane humidifiers are also utilized in fuel cells. There are some needs to analyze water contents of this new concept fuel cell. By increasing pressure, activities in fuel cells are increased, this means that operation in high pressure have advantage in flooding. In addition, membrane humidifier can prevent dry out in PEMFCs. To suggest optimal pressure range for high efficiency, this study conducts numerical analysis of changes of efficiency of PEMFCs as changing activity in 1D, steady state. Also, this paper analyzes fuel cell performance with membrane humidifier as activity changing with pressure change.