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Min Young Kim,Kyung Suk Song,Gun Ho Park,Hyun Woo Kim,Jin Hong Park,Jun Sung Kim,Hwa Jin,Kook Jong Eu,Hyun Sun Cho,Gami Kang,Chanhee Chae,Yoon Shin Kim,Young Chul Kim,Hae Yeong Kim,George Beck,Nancy C 한국독성학회 2004 Toxicological Research Vol.20 No.1
Changes in cell cycle control in the lungs and liver of the B6C3F1 mice (20 males per each group) exposed to ozone (0.5 ppm), 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1.0 mg/kg), and dibutyl phthalate (DBP, 5,000 ppm) after 52 weeks were examined through Western, Northern blot, and immunohistochemistry based on alterations in protein expression levels of G1/S checkpoints (cyclin D1, cyclin E, and PCNA), G2/M checkpoints (cyclin B1, cyclin G, and cyclin A), negative regulators (p53, p21, GADD45, and p27), and positive regulator (mdm2). Expression levels of cyclins D1, E, G, PCNA, mutant p53, and mdm2 proteins were higher in the lungs<br/> and livers treated with combination of toxicants than in those treated with ozone only. Expression levels of the wild-type and mutant p53, p21, GADD45, p27, and mdm2 proteins and mRNAs were<br/> higher in toxicant-treated groups than those of the control. Immunohistochemical analysis revealed staining intensities of the PCNA, cyclin D1, c-myc and mdm2 protein- treated lungs and livers were stronger than those of the control group. Our results showed that combined treatment of ozone with NNK/DBP altered the cell cycle control through instability of the wild-type p53 gene. Such pivotal p53-mediated cell cycle alterations may be responsible for the toxicity observed under our experimental condition. These results may be applied to risk assessment of mixture-induced toxicity.
Recent increase in pertussis incidence in South Korea: An age-period-cohort analysis
Kim Chanhee,Yi Seonju,Cho Sung-il 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Pertussis or whooping cough—one of the most contagious diseases—is caused by the Gram-negative bacterium Bordetella pertussis. Despite a high vaccination rate, Korea recently experienced a resurgence of pertussis. This study explores patterns and possible explanations for this resurgence through an age-period-cohort analysis. METHODS: Using secondary data from the infectious disease portal of the Korea Disease Control and Prevention Agency and the Korea Statistical Information Service of Statistics Korea, this study analyzed the incidence of pertussis in Korea to determine which factors contributed to the recent increase using an age-period-cohort model. RESULTS: Analysis of the age effect indicated that the age group most vulnerable to pertussis was 0-year to 2-year-olds. Analysis of the period effect showed a sharp increase in the incidence rate after 2016. Analysis of the cohort effect showed a significant decrease in incidence beginning with the 1955 birth cohort, with the risk increasing again with the 2000s birth cohort. CONCLUSIONS: Previous studies have suggested 3 main possible explanations for our results. First, the increased incidence rate can be attributed to contact rates. Second, the rate of immunity through natural exposure has decreased due to the low number of circulating pathogens, in turn affecting the trend of infection. Lastly, variations in pathogens may have also contributed to the increase in incidence. Given that the most significant increase in incidence was observed among infants younger than 1 year old, sufficient maternal immunity must be prioritized to provide passive immunity to newborns via the placenta.
Expression of Mucins in the Mucosal Surface of Small Intestines in 1 Week-Old Pigs
KIM, Chung Hyun,OH, Yeonsu,HA, Yooncheol,AHN, Qwein,KIM, Sung-Hoon,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.2
<P>The aim of this study was to determine the immunoexpression of mucins in jejunal and ileal villous epithelium using six antibodies against MUC1, MUC2, MUC4 MUC5AC, MUC5B and MUC6. The immunohistochemical score for MUC1 has significantly intense staining compared with MUC2 (<I>P</I>=0.008) and the immunohistochemical socre for MUC4 and MUC 6 has significantly intense staining compared with MUC2 (<I>P</I>=0.032) in ileal villous surface. The immunohistochemical score for MUC4 (<I>P</I>=0.008), MUC5AC (<I>P</I>=0.016) and MUC6 (<I>P</I>=0.016) in ileal villous surface has significantly intense staining compared with ileal cryptic surface. The results of this study demonstrated that six mucins gave distinctly different expression patterns throughout the 1 week-old porcine small intestinal tract.</P>
KIM, Duyeol,HA, Yooncheol,LEE, Yong-Hoon,CHAE, Sungwon,LEE, Kichan,HAN, Kiwon,KIM, Junghyun,LEE, Ju-Ho,KIM, Sung-Hoon,HWANG, Kyu-Kye,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.7
<P><I>In situ</I> hybridization and immunohistochemistry with different types of antibody (monoclonal vs. polyclonal, natural vs. synthetic) was compared to detect porcine circovirus 2 (PCV2) in formalin-fixed, paraffin-embedded tissues from pigs with experimentally and naturally occurring postweaning multisystemic wasting syndrome. PCV2 DNA and antigen was detected in tissues from both experimentally and naturally infected pigs by <I>in situ</I> hybridization and immunohistochemistry, respectively. Statistical evaluation revealed that more PCV2 positive signals were significantly detected in both experimentally and naturally infected pigs by <I>in situ</I> hybridization compared with immunohistochemistry (<I>P</I><0.05). The results of this study demonstrated that<I> in situ</I> hybridization proved more sensitive than immunohistochemistry for the detection of PCV2 in formalin-fixed, paraffin-embedded lymph node tissues.</P>
Kim, Duyeol,Ha, Yooncheol,Oh, Yeonsu,Han, Kiwon,Noh, Seung Ho,Kim, Cheolwoo,Kim, Sung-Hoon,Chae, Chanhee AAVLD 2010 JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION Vol.22 No.2
<P>The aim of the current study was to develop a nonradioactive in situ hybridization assay that can differentiate between genotypes 2a and 2b of Porcine circovirus-2 (PCV-2) in formalin-fixed, paraffin-embedded lymph node tissues from pigs with postweaning multisystemic wasting syndrome. Two different digoxigenin-labeled oligonucleotide probes were designed from the PCV-2 open reading frame 2 sequences. The PCV-2a-specific probe did not hybridize with formalin-fixed, paraffin-embedded lymph nodes from naturally PCV-2b-infected pigs and vice versa. Both PCV-2a-specific and PCV-2b-specific probes gave consistent negative signals in lymph nodes from naturally PCV-1-infected pigs. The in situ hybridization assay described in the present study represents a diagnostic tool that can differentiate between the 2 genotypes of PCV-2.</P>
Sources of Meaning in Life for Korean Older Adults during the COVID-19 Pandemic: A Qualitative Study
Chanhee Kim,KyungIm Kang,Min Hye Lee 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim: The coronavirus (COVID-19) pandemic has significantly affected the lives of older adults. It has been established that meaning in life for older adults is closely associated with health, quality of life, and well-being. However, little attention has been given to examining what provides them with meaning in life during the pandemic. The aim of the study was to explore sources of and impacts on meaning in life for older adults during the pandemic. Methods: A qualitative study was performed from June to July 2021. Six focus group interviews with 18 Korean older adults were conducted, and data were recorded and analyzed using the content analysis method. Results: According to the results of data analysis, the following three subcategories were extracted under the category “sources of meaning in life for older adults: moving continuously forward”; “practicing beyond myself”; “continuous learning and personal growth”; and “striving to maintain health.” Under the category “sources of meaning in life for older adults after COVID-19: adapting to change,” the following two subcategories were extracted: “significant change caused by the pandemic” and “diametrically opposite adaptation to the pandemic.” Conclusions: This study explored sources of meaning in life for older adults during the prolonged COVID-19 pandemic, and is therefore helpful in identifying how older adults’ meaning in life has changed. The study results are useful in enhancing meaning in life of older adults, thus improving their health, quality of life, and well-being, despite the ongoing COVID-19 pandemic.
Kim, Duyeol,Han, Kiwon,Oh, Yeonsu,Kim, Chung Hyun,Kang, Ikjae,Lee, Jeehoon,Gottschalk, Marcelo,Chae, Chanhee Canadian Veterinary Medical Association = Associat 2010 Canadian journal of veterinary research Vol.74 No.4
<P>The objective of this study was to determine the capsular serotypes and potential virulence factors of Streptococcus suis isolated from pigs with polyserositis. Among the 24 isolates evaluated, serotype 3 [7 (29%) of the isolates] and serotype 4 [5 (21%)] were the most common. The isolates were also studied for the presence of the genes mrp, epf, and sly, which encode muramidase-released protein (MRP), extracellular factor (EF), and suilysin (SLY), respectively. Of the 24 isolates, 8 carried mrp: 4 of serotype 3, 2 of serotype 2, and 2 of serotype 4. One mrp(+) isolate (serotype 2) also carried the epf gene. All 24 isolates carried the sly gene. The serotype and genotype distribution greatly differed from that reported for isolates from pigs with other clinical manifestations of S. suis infection in other countries.</P>
Kim, Chanhee,Kim, Sun Ji,Jeong, Jinkil,Park, Eunae,Oh, Eunkyoo,Park, Youn-Il,Lim, Pyung Ok,Choi, Giltsu Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.7
Leaf senescence is a developmental process by which a plant actively remobilizes nutrients from aged and photosynthetically inefficient leaves to young growing ones by disassembling organelles and degrading macromolecules. Senescence is accelerated by age and environmental stresses such as prolonged darkness. Phytochrome B (phyB) inhibits leaf senescence by inhibiting phytochrome-interacting factor 4 (PIF4) and PIF5 in prolonged darkness. However, it remains unknown whether phyB mediates the temperature signal that regulates leaf senescence. We found the light-activated form of phyB (Pfr) remains active at least four days after a transfer to darkness at 20℃ but is inactivated more rapidly at 28℃. This faster inactivation of Pfr further increases PIF4 protein levels at the higher ambient temperature. In addition, PIF4 mRNA levels rise faster after the transfer to darkness at high ambient temperature via a mechanism that depends on ELF3 but not phyB. Increased PIF4 protein then binds to the ORE1 promoter and activates its expression together with ABA and ethylene signaling, accelerating leaf senescence at high ambient temperature. Our results support a role for the phy-PIF signaling module in integrating not only light signaling but also temperature signaling in the regulation of leaf senescence.
KIM, Bongtae,AHN, Kyoung Kyu,HA, Yooncheol,LEE, Yong Hoon,KIM, Duyeol,LIM, Jeong Han,KIM, Sung-Hoon,KIM, Mi-Young,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.5
<P>The relationship between tumor necrosis factor (TNF)-α level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-α was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-α concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (<I>P</I><0.05) and steady thereafter. Mean rectal temperatures were above 40°C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-α in BAL fluids from pigs experimentally infected with SIV (<I>r</I><SUB>s</SUB>=0.9754, <I>P</I><0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF- α (<I>r</I><SUB>s</SUB>=0.9949, <I>P</I><0.001). The results suggest that the expression of TNF-α protein plays an important role in induction of pulmonary lesion and clinical sign such as fever in SIV infection.</P>
KIM, Bongtae,LEE, Kichan,HAN, Kiwon,KIM, Duyeol,HA, Yooncheol,KIM, Chung Hyun,OH, Yeonsu,KANG, Ikjae,LEE, Jeehoon,CHAE, Chanhee Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.9
<P>The aim of this study was to develop <I>in situ</I> hybridization for detection of <I>Mycoplasma hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from pigs with polyserositis. <I>M. hyorhinis</I> was isolated from the spleen (2 pigs) and pericardium (1 pig). <I>M. hyorhinis</I> DNA was detected 16 out of 20 pigs with polyserositis. <I>In situ</I> hybridization produced a distinct positive signal for the <I>M. hyorhinis</I> p37 gene in inflammatory cells in the polyserositis. <I>In situ</I> hybridization developed in the present study present diagnostic tools capable of detection of <I>M. hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from the naturally infected pigs.</P>