랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

Study on bubble and liquid velocities in an area-varying horizontal channel

Tran, Thanh Tram,Kim, Byoung Jae,Park, Hyun-Sik Elsevier 2018 Annals of nuclear energy Vol.118 No.-

<P><B>Abstract</B></P> <P>Two-fluid equations are widely used to simulate thermal-hydraulic phenomena in a nuclear reactor. Simulation accuracy depends on the modeling terms in the two-fluid equations. For a dispersed flow, the overall two-phase pressure drop by wall friction must be apportioned to each phase in proportion to the fraction of each phase (Kim et al., 2014). By applying this approach, the prediction of bubble phase velocity can be close to that of liquid for a fully developed flow in a horizontal pipe with a constant area. One may want to know what would happen in the area-varying channels. It is always true that the bubble density is much lower than the water density. Hence, the bubble would accelerate faster than the liquid in a nozzle in which the pressure decreases along the downstream; the bubbles would decelerate more quickly than the liquid in a diffuser in which the pressure increases along the downstream. The purpose of this study was to investigate those behaviors in an area-varying channel using the experimental data and MARS simulations. Experiments were made of turbulent bubbly flows in an area-varying horizontal channel. The velocities of two phases were measured with the help of the PIV technique. The experimental result showed that the two-phase velocities were no longer close to each other in the area-varying regions. The bubble was faster than the liquid in the nozzle region; in contrast, the bubble was slower than the liquid in the diffuser region. MARS code simulations were performed to assess the wall drag model. By replacing the original wall drag partition model in the MARS code with Kim’s one, the simulation results were consistent with experimental observations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bubble and water velocities in an area-varying channel are measured. </LI> <LI> The phase velocities are very close in the constant-area region. </LI> <LI> The bubble is faster than the water in the contraction region. </LI> <LI> The bubble is slower than the water in the diffuser region. </LI> <LI> Kim’s wall drag partition model well predicts experimental results. </LI> </UL> </P>

BSA고정화를 위한 가교제의 첨가특성

김재훈,김민,김병식 한국공업화학회 2004 응용화학 Vol.8 No.2

Anion exchange groups(DEA) were introduced into porous hollow fiber membranes by radiation-induced ploymerization. A DEA group-containing polymer chain grafted onto a porous PE membrane. The BSA solution was forced to permeate across the hollow fiber DEA membrane. BSA was immobilized by the permeation of a BSA solution through the pore of the DEA membrane. The immobilized BSA was cross-linking with glutaraldehyde to prevent leakage. Afterwards, The GA 0.05 percent membrane having higher adsorption capacity than 0.025, 0.075, 0.1 percent GA concentration.

이성질체 분리를 위한 음이온교환재료의 합성

김재훈,김민,김병식 한국공업화학회 2003 응용화학 Vol.7 No.2

Anion exchange groups were introduced into porous hollow fiber membranes by radiation-induced ploymerization. The epoxy group produced in the GMA-grafted hollow fiber membrane was converted into anion-exchange groups by reaction with Diethylamine(DEA). Triethylamine(TEA). Ethanolamine(EtA). Diethanolamine(DEtA). The D-, L-Tryptophan solution was forced to permeate across the hollow fiber DEA, TEA, EtA, DEtA memberan. When measurements of anion-exchange capacity of the DEA, TEA, EtA, DEtA memberan, the DEA membrane having higher adsorption capacity than TEA, EtA, DEtA membrane.

저공해농약(곤충발육저해제)의 주요 해충에 대한 살충실험

金正和,李炯來,金柄植,李仁煥 충북대학교 농업과학기술연구소 1993 農業科學硏究 Vol.11 No.1

The experiments were carried out on toxicological comparisons of the new insect growth regu- lators(IGR) against the fall webworm(Hyhamtria cunea) and the house fly(Musca domestica). The LC50 values of tebufenozide, chlorfluazuron and diflubenzuron against the Hyphantria cunea in the 3rd instar stage within the 1st generation collected in cheongju, were 6.0894, 7.7768 and 9.1322 ppm, respectively. In toxicological studies at the 0.5ppm level of chlorfluazuron and buprofezin against the different larval stages of Musca domestica, the ratio of pupation was 20%~35% at the 1st instars, but not shown at the 2nd and 3rd instars, while, the ratio of emergence showed the decreasing tendency at the different stages. In high doses(5, 25, 50, 500ppm) of chlorfluazuron and pyriprozyfen against the house fly in the 2nd instars, the ratio of pupation in chlorfluazuron showed the decreasing tendency at the high dose but pyriproxyfen did not. The ratios of emergence in two IGR showed 0% without regard to dose. In determination(LC50) of the tested IGR against the house fly in the 2nd instars, the ratio of pupation did not show any differences in all IGRs, but the ratio of emergence showed a decreasing tendency with the increasing doses. The LC50 values of pyriproxyfen, chlorfluazuron and buprofezin were 0.0527, 0.0898 and 13.7669 ppm, respectively.

코먼레일 單汽筒 디젤엔진에서 GTL 熱料의 噴射時期 變化에 따른 排出物 特性에 關한 硏究

金秉儁,崔源鶴,柳鍾植,李海喆,車京玉 명지대학교 산업기술연구소 2008 産業技術硏究所論文集 Vol.27 No.-

Recently, alternative fuels are drawing more attentions due to the increasing need for lower emission characteristics and fuel consumption rate in automotive engines. The GTL(gas to luquid) is the one of most favored candidates. It has higher cetane number(more than 75) and almost negligible sulphur and aromatic contents. Therefore, enhanced emission characteristics are expected even in the application in diesel engines without any modification. In this study, the cylinder pressure and heat release, emission characteristics with fuel injection timings are compared between diesel and GTL fuel in the single cylinder diesel engine. Noticeable reduction in PM, THC and CO emission are observed due to lower sulphur and aromatic contents in GTL. Also, the ignition delay decreased due to higher cetane number of GTL , which slightly decreased the amount of NOx emissions. With the retards of main injection timing. NOx decreases more for the case of GTL, while the level of THC and CO emissions still remains lower than the case of diesel. Therefore, there is much room for the control of injection timiing for NOx reduction without sacrificing THC and CO emissions. With the retards of main injection timing, Small size distribution of PM became lager and there amount increased. But from all conditions, size distribution of PM for the case GTL was lower than Diesel.

품질기능 및 비용 전개를 위한 소프트웨어 Tool 개발

김정식,장현수,이병기 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

QFD is a method for supporting product planning and development processes. This method enables to specify clearly the customer's needs and then evaluate the product capability in terms of its impact on meeting those needs, The QFD process involves constructing the HoQ matrix which consists of the customer requirements, the engineering characteristics to meet those requirements, and the evaluation factors in the planning matrix. The QFD often produces different results according to each evaluation factor in the matrix. Therefore, am integrating technique is required to solve the problem. This paper provides the technique which integrates the QFD analysis results due to different evaluation factors. The technique also considers the production cost as an evaluation factor to help produce an economical solution. Finally, a software tool for supporting the comprehensive QFD process is developed and implemented using the Visual Basic of Microsoft Excel.

Spiral Wire 충전진동탑을 이용한 용매추출제의 유동특성

김우식,김병식,이태규 연세대학교 대학원 1980 延世論叢 Vol.16 No.2

Dynamic Characteristics of a Vibrating Column Packed with Spiral Wires in Liquid-Liquid Solvent Extraction. Dynamic characteristics of liquid-liquid extraction in vibrating column packed with spiral wires was studied. The experiment was done for the kerosene-water system without mass transfer on the assumption of axial dispersion model. In the experiment, residence time distribution curves were obtained and the holdup of kerosene was measured by changing vibration frequency and kerosene linear velocity. In the experiment of residence time distribution, NaOH was used as a tracer and HCl as a titrating solution. The experimental results showed that this equipment had a large holdup and an approach of dispersion model at the degree of vibration, 46Hz.

소아 Henoch-Schonlein 신염의 임상경과와 조직학적 특성 : Renal Outcome and Prognostic Factors

김병목,장창환,조민현,곽정식,고철우,구자훈 대한신장학회 2003 대한신장학회잡지 Vol.22 No.6

새열기형의 임상적 고찰

김장묵,김대식,백승혁,한동렬,김희중,백병준,오천환 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background and Objectives : Branchial cleft anomalies are encountered rarely in clinical practice. We reviewed medical records of branchial cleft anomalies according to age and sex distribution, site distribution, characteristics of mass on physical examination, location of mass, preoperative diagnosis, type of branchial cleft cyst and report our experience with 25 cases of branchial cleft anomalies. Materials and Methods : A review of medical records was performed on 25 cases of branchial cleft anomalies diagnosed in pathologic report from January, 1990 to March, 2000. Result : Sex distribution was 11 male and 14 female, age distribution was most common in third decade which was 8 cases(32%). Site distribution was predominant in left side(13 cases), and in physical examination, the characteristics of the mass was nontender(76%), mobile(60%), soft(80%). The lesion site was submandibular area in 2 cases, upper 1/3 portion of sternocleidomastoid muscle(SCM) in 2 cases, middle 1/3 portion of SCM in 20 cases and parotid area in 1 case. The preoperative diagnosis was branchial cleft cyst in 16 cases, cervical lymphadenitis in 3 cases, tuberculous lymphadenitis in 3 cases, branchial cleft fistula in 1 case, dermoid cyst in 1 case and parotid mass in 1 case. Among 25 cases, first branchial cleft cyst was seen in 4 cases, second branchial cleft cyst in 20 cases and second branchial cleft fistula in 1 case. Conclusion : The clinical history of recurrent neck inflammatory episodes in young patients and nontender, mobile, soft neck mass should raise the suspicion of this entity. Investigation using CT scanning in combination with aspiration is useful. Treatment of all branchial cleft anomalies is complete surgical excision because there is lack of spontaneous regression, a high rate of recurrent infection, the possibility of other diagnosis, and rare malignant degeneration. Complete removal without complications depends on a good understanding of regional embryogenesis, a knowledge of the surrounding structure, and awareness of the different anatomical presentation.