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민덕기,박기헌 成均館大學校 科學技術硏究所 2000 論文集 Vol.51 No.1
This paper presents a method for the design of 3DOF (3-Degree-of-Freedom) Wiener-Hopf controllers which improve design capability of the conventional 1DOF controllers. The new method allows optimal formula for a MIMO system. This paper proposes the structure of 3DOF controller which makes it possible to treat disturbance, measurement noise and reference input independently. Wiener-Hopf optimization technique is used to obtain the optimal and robust controller which stabilizes the generalized plant and minimizes a cost function of a quadratic form. In this paper, state-space representations of the 3DOF Wiener-Hopf controllers are presented in terms of ARE solutions.
황신일,민덕기,조상덕,김수일 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.2
The friction resistance of a pile is the major contribution to the bearing capacity of friction piles. In this paper, an empirical equation for the friction capacity of steelpipe piles in sand is proposed through the laboratory pullout test. Pullout tests are carried out for the piles with length to diameter ratios of 4 to 10. The density levels of sand selected in the test are very loose, loose, medium and dense. The experimental analysis shows that the friction capacity is linearly increased with the internal friction angle of sand, and it also shows that the friction capacity is linearly increased with the length to diameter ratio of piles. Also, an important parameter to determine the friction capacity of a pile, the lateral coefficient of earth pressure, shows good correlations when compared with other pile equations.
부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로
김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.
아리스톨로크산 함유 생약제에 대한 안전성평가연구 : 3개월간 반복투여독성시험을 통한 신장독성평가
황명실,박미선,문지영,이지선,염영나,이효민,신동환,강진석,윤은경,최미나,육미영,장동덕,길광섭,김승희,양기화 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
본 실험에서는 아리스톨로크산을 함운하고 있는 생약제중 하나인 마두령(.4risfoforfioe JTurruf)의 90일 반복투여독성시헌을 실f,」하였다. 마두령에서 아리스톨로크산을 정량분석한 결과 마두령 단일 건조븐말의 경운 2.112mg/g, 잉상에서 처방되고 있는 마든령복방 (마두령외 9가지 생약제 복합처방) 건조분말꼭 경무에는 0.066m9/5으로 각각 검출되었다. 본 실험에서 용량설정은 마두령 처리군 (저용량 군; 21.3m9/k9/day (임상용량), 중용량군; 2t3mgfg/day, 고용량군; 2430mg딘g b.w./day), 마두령복방 처리군 (427mg/kg b.w./da?; 임상용량) 및 positive control (아리스톨로크산) 처리군 (저용량군;0.05mgag/da17, 중용량군; 0.Smg/kg/day, 고용량군; 5mg./kg/dal·1으료 하여 랫드에게 경구투여하였다. 마두령단방 처궈근 및 마두령복방 처리군에서 저용량군과 중응량군에서는 잉상관찰 및 생화학적 분석에서 패조군과 유의적인 차이가 없었다. 그러나 마두령단방 고용량근에서는 간, 신장의 상대적인 무계가 증가되었고, 신장의 유두이행상피증식 및 암종이 관찰되었으며, 위에서는 편평세포암종이 관찰되었다. 하자만 간손상이나 간암은 유발하지는 않는 것으로 판단되었다. 결론끌으로 본 실험의 결과에서는 아리스톨로크산 함유 생약제인 마두령이 임상용량인 저응량 처리군에서는 독성을 나타내지 않았으나, 고용쏭으로 장기 복용시켰을 깅우 설치류의 전위부위 및 신장에서 독성이 있음을 알 수 있었다. Chines herbs nephropathy (CHN) has been described in young women who had taken a slimming pills containing some chines herbs. Aristolochic acid (AA), suspected substance as the causal factor of CHN, is known a carcinogen. The Aristolochiae fructus (fruit of Aristolochia contorta) was used in Korean Traditional Medicine consists of appropriate amounts of mixed natural products. Subchronic toxicity of A. furctus containing aristolochic acid was investigated in SD rats. The body weight and clinical signs were observed after orally administration of A. futctus at doses of 21.2, 213, and 2130 mg/kg/day; mixture (including 9 other herbs) at dose of 427 mg/kg/day; aristolochic aicd (Ⅰ+Ⅱ) at doses of 0.05, 0.5, and 5 mg/kg/day for 3 months. At the end of the treatment, high dose treated animals revealed a deficit in final body weight about 25% compared with that of control. Organ weights of kidney, liver, testis, or ovary were increased with dose dependent manner. No changes considered to be due to the administration of A. furctus, mixture or aristolochic acid were in hematological and clinical study. However, significant changes at histopathological study of kidney and stomach were boserved in high-dose treated groups. In conclusion, for human health safety it needs appropriate regulatory actions regarding the use of natural herbal medicines known or suspected of containing aristolochic acid.
Lee, Deuk Ki,Min, Da Young,Seo, Hwimin,Kang, Na Young,Choi, Won Choon,Park, Yong Ki American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.26
<P>For the kinetic study of K<SUB>2</SUB>CO<SUB>3</SUB>/ZrO<SUB>2</SUB> sorbent in the carbonation reaction to capture CO<SUB>2</SUB> from the flue gas, reaction experiments were carried out at temperatures between 328 and 343 K for CO<SUB>2</SUB> gas compositions not exceeding 18% at 1 bar, and a phenomenological kinetic model was proposed to fit the carbonation conversion data obtained. Time-dependent carbonation conversions of the sorbent appeared as sigmoid curves. Sigmoid characteristics of the conversion curve were more pronounced for the sorption reaction at lower temperature and lower gas phase concentration of CO<SUB>2</SUB>. Such conversion behavior of fresh-dried K<SUB>2</SUB>CO<SUB>3</SUB>/ZrO<SUB>2</SUB> sorbent could be closely described with the reaction rate equation in the form: <I>r</I> = <I>k</I><I>f</I>(<I>X</I>)<I>y</I><SUB><I>CO</I><SUB>2</SUB></SUB><SUP><I>n</I></SUP> . The reaction rate constant <I>k</I> as a temperature dependent term could be represented by Arrhenius’ equation with the negative apparent activation energy of −17.43 kJ/mol and the pre-exponential factor of 3.83 × 10<SUP>–3</SUP> 1/min. The term <I>f</I>(<I>X</I>) was a function introduced to reflect the carbonation rate change with the fractional carbonation conversion <I>X</I> of the sorbent, and its parameters were determined by correlation equations of the reaction temperature and the gas phase concentration of CO<SUB>2</SUB>. The reaction order <I>n</I> with respect to <I>y</I><SUB>CO<SUB>2</SUB></SUB>, the gas phase mole fraction of CO<SUB>2</SUB>, was determined to be 0.49. And, the characteristics of K<SUB>2</SUB>CO<SUB>3</SUB>/ZrO<SUB>2</SUB> sorbent in the carbonation reaction for CO<SUB>2</SUB> capture was discussed in relation to the kinetics obtained.</P>
Ki, Min-Hyo,Paik, Kee-Joo,Lee, Ji-Hyeon,Chung, Hae-Young,Lee, Kyung-Hee,Kim, Kyu-Won,Kim, Nam-Deuk The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3
Retinoids are applied to not only cancer prevention but also cancer chemotherapy by stimulating differentiation of cells. We studied differentiation inducing effect of all-trans retinoic acid (ATRA) by studying proportion of high dense fractions of stem-like cells and the size of S phase fraction in cell cycle. From mammary organoids obtained from 7- to 8-week old F344 female rat mammary gland, we cultured rat mammary epithelial cells (RMEC) and treated physiological doses of $10^{-6}$, $10^{-7}$, and $10^{-8}$ M ATRA from the first day and then cultured for 4, 7, and 14 days. After that, immunostaining was performed using peanut agglutinin (PNA) and anti-Thy-1.1 monoclonal antibody (Thy-1.1) that can be used as markers of differentiation. We separated four different cell subpopulations by flow cytometry: cells negative to both reagents (B-), PNA-positive cells (PNA+), Thy-1.1-positive cells (Thy-1.1+), and cells positive to both reagents (B+). We observed continuous decreases of high dense fractions of stem-like cells (PNA+ subpopulations) for 14 days and as much decreases as high doses of ATRA, which were thought to be proportional to doses of ATRA. We labeled RMEC with bromodeoxyuridine and investigated cell cycle fractions that went through S phase. We observed a tendency of decrease of S phase fraction with time in culture, which, is thought to be related to continuous decreases of PNA+ subpopulations and inhibitory role of ATRA on cell cycle. These results suggest that physiological doses of ATRA could stimulate differentiation of RMEC and convert stem-like RMEC to differentiated cells in SFM for a relatively long period of 14 days.