랫드에서 단일시험법을 이용한 반하 물추출물의 생식독성시험

이기남,유욱준,백인정,연정민,남상섭,이범준,남상윤,김윤배,강현규,안병우,김대중,황방연,노재섭,홍정섭,성하정,김순선,조대현,윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

토끼에서 enrofloxacin과 enrofloxacin acetate의 比較藥物動態學

윤효인,박승춘,김창식,김민규,최기섭,신광순,박종일,조준형,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

This study was designed to examine the in vitro antibacterial activities and pharmacokinetics of enrofloxacin acetate (ENFXA) and enrofloxacin (ENFX). Two enrofloxacins had wide spectrum antibacterial activities against Gram positive and negative bacteria, and mycoplasma, showing potent antibacterial activities with low MICs (0.05-3.33 ㎍/㎖ for Gram positives, 0.002 ㎍/㎖ for Gram negatives and 0.02 ㎍/㎖ for mycoplasma). In order to investigate the profiles of two formulations of enrofloxacin we studied comparative pharmacokinetics of them in rabbits. Five rabbits were given 5 ㎎/㎏ body weight of each enrofloxacin formulation intravenously (i.v.) and orally (p.o.) in a cross-over study. Pharmacokinetic parameters of both formulations were calculated by the use of PCNONLIN, a computer program. Their bioavailibility in rabbits, the means of the area under the curve (AUC). After oral administration of each formulation in rabbits, the mean elimination half-lives (t_1/2,ke) were 3.25h (ENFX) and 4.32 h (ENFXA), and mean AUC 4.27 ㎍·h/㎖ (ENFX) and 6.21 ㎍·h/㎖ (ENFXA). Both enrofloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution: 4.76 1/㎏ for ENFX and 7.23 1/㎏ for ENFXA. With the results obtained in this study, ENFXA could be used in place of ENFX in rabbits.

향토수목원 및 관광지 조경을 위한 자생식물의 개발과 이용

윤영활,서옥하,이기의,조현길 江原大學校 森林科學硏究所 1998 Journal of Forest Science Vol.14 No.-

要約우리는 우리 지방에 자생하면서 기후풍토에 적응된 아름답고 진귀한 많은 화목류와 교목류 등을 부존하고 있으면서도 이들을 연구 개발하지 않고 주로 도입종과 재배종에만 의 존하고 있는 것이 오늘의 현실이다. 그러므로, 국내외의 광광객이 dyurn하는 즉, 강원도는 물론 우리나라 고유의 정취와 이미지를 줄 수 있는 많은 야생종들을 연구, 개발하여 조경식 물화시켜 대량으로 번식시키는 동시에 일반 재배화함으로써 향토색 짙은 관광한국을 만들어 관광사업의 근본목표인 경재적 효용을 다하기 위해 매우 개발가치가 있는 교복류 37종과 관 목류 73종의 특성, 재배법, 용도 등을 조사하였다.ABSTRACTThis study examined ecophysiological characteristics, cultivation methods and planting uses of tree and shrub species native to Kangwon province and valuable as landscape plants.The results were as followos :1. 73 species selected as shrubs were; Rhododendron brachycarpum, Rhododendron micranthum, Abelia mosanensis, Abeliophyllum distichum, Acanthopanax sessiliflorus, acanthopanax senticosus, Alangium platanifolium var. macrophyllum etc. 2. 38 species selected as trees were ; Cornus controversa, Sorbiis commixta. Mains baccata, Prunus padns, Acer triflorum, Acer tegmentosum, Styrax japonica, Styrax obassia, Sorbiis ainifolia etc. 3. Shade-tolerant species were ; Abies koreana. Rhododendron brach\carpum. Rhododendron micranthum, Primus padus, Sorbus commixta, Acer triflorum, Rhus japonica, Cornus kousa, Kalopanax pictus, Chionanthus retusa, Sorbus ainifolia, Magnolia sieboldii, Sorbaria sorbifolia var. stellipila, Berberis koreana, Lindera obtiisiloba, Rhododendron schlippenbachii and Euonymus alatiis. 4. Species growing well even in less fertile soils were ; Finns thunbergii, Quercus dentata, Koelreuteriapaniculata, Rhus japonica, Quercus acutissima, Albiz^ia julibrissin, Sorbus ainifolia, Staphylea buinalda, Philadelphus schrenckii, Clerodendron Iriclwtomum, Deut^ia coreana, Weigela florida, Zanthoxyiuin schinifolium and Lindera obtusiloba. 5. Salt-tolerant species were ; Finns thunbergii, Quercus aliena, Primus padus, Styrax japonica, Quercus dentata, Kalopanax pictus, Chionanthus retusa, Albizua julibrissin, Tilia amurensis, Forsvthia koreana, Lonicera inaackii, Samplocos chinensis for. pilosa, Clerodendron trichotomum, Sambiicus williamsii var. coreana, Abelia mosanensis, Deutua coreana. Viburnum cariesii, Rhus japonica, Rhododendron yedoense var. poukhanense, Zanthoxylum schinifolium, Callicarpa dichotoma, Rhododendron schlippenbachii and Euonymusalatus. 6. Pollutant-tolerant species were ; Styrax japonica, Prunus padus, Quercus dentata, Kalopanax pictus, Chionanthus retusa, Gleditsia japonica var. koraiensis, Styrax obassia, Forsythia koreana, Spiraea salicifolia, Clerodendron trichotomum. Viburnum sargentii, Viburnum cariesii, Weigela florida and Rhododendron vedoense var. poukhanense.

정보 제공을 위한 분산 웹서버의 설계 및 구현

김기환,이봉하,윤성일 공주영상정보대학 2001 논문집 Vol.8 No.-

본 논문에서는 네트워크 상에 분산되어있는 정보 자원의 실행 및 공유를 수행하는 웹 서버에 대한 부하를 여러 대의 유휴 웹 서버를 이용해서 분산시키는 방안 및 부하 분산을 위한 여러 대의 중계자 서버를 이용하는 방안을 제시하였다. 중계자 서버를 이용한 분산 웹 서버 시스템은 클라이언트로부터 발생되는 모든 서비스 요구를 중계자 서버가 모두 수용한 후 하부의 웹 서버들에게 Job을 분산시키는 방식을 이용하여 웹서버의 부하를 감소시켰다. 또한 데이터베이스의 연동 시스템 통합에 있어서 독립형 서버에서 수행되는 CGI 응용 프로그램 일부를 여러 대의 유휴 웍스테이션 웹 서버에 CGI 응용프로그램을 할당함으로서 기존의 독립 서버에서 발생하는 과부하의 단점을 해결하는 분산 웹 서버 시스템 모델을 효과적으로 제안하였으며, 또한 네트워크 상에 분산되어있는 정보 자원의 실행 및 공유를 수행하는 웹 서버에 대한 부하를 여러 대의 유휴 웹 서버를 이용해서 분산시키는 방안 및 부하 분산을 위한 여러 대의 중계자 서버를 이용하는 방안을 제시하였다. 또한 이러한 정보를 제공하면서 간단한 HTML은 일반 중계자 서버에서 처리하고 대 용량의 처리는 중계자 서버의 부하를 없애기 위하여 분산 서버를 이용하여 효과적으로 구현하였다.

平胃散과 平胃散 構成藥物의 加減方이 摘出臟器, 抗瀉下作用 및 中樞神經系에 미치는 影響

柳逢夏,朴東源,柳基遠,金倫寬 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

The aim of this experimental study was to investigate the effects of Pyungwee-san samples on the movement of gastrointestinal smooth muscles, anticatharsis, and central nervous system by using rats or mice. Samples were divided into five groups : Sample-Ⅰ : Pyungwee-san(Atractylodes Rhizoma, Aurantii Nobils Pericarpium, Magnoliae Cortex and Glycyrrhizae Radix), sample-Ⅱ : Exclusion of Atractylodes Rhizoma from Pyungwee-san, Sample-Ⅲ : Exclusion of Aurantii Nobils Pericarpium from Pyungwee-san, Sample-Ⅳ: Exclusion of Magnoliae Cortex Rhizoma from Pyungwee-san, Sample-Ⅴ : Exclusion of Glycyrrhizae Radix from Pyungwee-san. The results were as follows : 1. All samples showed inhibitory effect on the motility of the isolated ileum and relaxant effect on the contracted ileum induced by acetylcholine chloride and barium chloride, these effects were dependent on their concentrations. 2. All samples in which sample-Ⅲ was exclude showed inhibitory effect on the motility of the rat fundus strip and relaxant effect on the contracted fundus strip induced by acetylcholine chloride and barium chloride, these effects were dependent on their concentrations. 3. Anticathartic effect of Pyungwee-san samples was appeared in sample-Ⅰ, sample-Ⅳ, sample-Ⅴ after drug medication in caster oil induced diarrhea. 4. Analgestic effect of Pyungwee-san samples on inhibition of writhing syndrome by acetic acid was recognized in sample-Ⅰ, sample-Ⅱ, sample-Ⅴ. 5. Effect of Pyungwee-san samples prolonging the hypnotic duration by pentobarbital-Na in Mice was shown in sample-Ⅱ, sample-Ⅲ. 6. Effect of Pyungwee-san samples on prolonging the time to death induced by strychnine was appeared in sample-Ⅳ(p<0.001). 7. Effect of Pyungwee-san samples on Picrotoxin-induced Convulsion in mice was appeared in all samples and on prolonging the time to death induced by strychnine was appeared in sample-Ⅱ, sample-Ⅲ, sample-Ⅳ. 8. Effect of Pyungwee-san samples on Caffeine-induced Convulsion in mice was appeared in sample-Ⅰ(p<0.01), sample-Ⅳ(p<0.05).

토양미생물

이영하,윤기영,염선분 忠南大學校 環境問題硏究所 1991 環境硏究 Vol.9 No.-

전라북도 진안군 용담면을 중심으로한 그 일대에서 선정된 8지점의 토양을 채취하고 이를 대상으로 토양미생물의 개체군 크기와 이화학적 토양환경을 조사하였다. 토양의 pH는 3.9-6.6(평균 5.3)의 범위로서 대체로 높은 토양산도를 나타내었다. 수분함양은 2.8-20.5%(평균12.6%)의 범위를 보였고 총 유기물함량은 3.5-16.0%(평균8.6%)의 범위로 지역에 따른 차이가 많았다. 일반세균과 일반진균의 개체군 크기는 각각 6.0-81.7×10?cfu/g soil과 8.6-30.4×10⁴cfu/g soil의 범위를 보였으며, 평균치는 각각27.4×10? cfu/g soil 과 17.4×10⁴cfu/g soil로서 세균과 진균의 상대적 평균비는 약 16 : 1이었다. 이러한 결과는 본 조사지역의 토양이 미생물의 생장과 활성이 비교적 활발하지 못한 환경임을 보여준다. 한편 섬유소분해세균과 진균은 각각 총세균(일반세균)과 총진균(일반진균)의 개체군 크기와 매우 높은 상관관계를 보였다. 섬유소분해세균의 개체군은 총세균의 5.8-29.5%(평균 16.6%)에 달하는 수준을 보였으며 섬유소분해진균의 개체균 규모는 총진군의 36.5-66.0%(평균 51.3%)수준이었는데, 이는 본 조사지역의 토양내 섬유소물질의 분해에는 상대적으로 진균의 활성이 보다 크게 작용하고 있음을 보여줄 뿐 아니라 본 조사지역의 토양환경이 우리나라의 다른 토양들에 비하여 토착성 미생물의 비중이 높은 생태임을 나타내 준다.

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

Tocopherol 投與가 家兎의 增體 및 飼料利用性에 미치는 影響

林鍾佑,尹昌鉉,河正基,朴琦緖 진주농과대학 1970 진주농과대학 연구논문집 Vol.- No.9

本 試驗은 Tocopherol이 家兎의 增體 및 飼料利用性에 미치는 影響을 究明하기 위해 雌兎 20頭, 雄兎20頭 計 40頭를 8週間 試驗하였던바 다음과 같은 結果를 얻었다. 1. 日當 增體量에 있어서는 處理區間에 1% 水準의 有意性이 認定되었으며 T₂區가 14.68g, T₁區가 13.17g로서 對照區보다 優秀하였으나 T₃區는 對照區보다 좋지 않았다. 2. 飼料攝取量에 있어서는 處理區間과 性別間에 1%水準의 高度의 有意性이 認定되었고 T₂區, T₁區가 對照區보다 飼料攝取量이 많았으나 T₃區는 對照區보다 不良했다. 3. 飼料利用率에 있어서는 處理區에 있어서 別다른 差가 認定되지 않았다. This experiment was conducted to study the effects of Tocopherol on gain weight, feed consumption and feed conversion of growing rabbits. Twenty male and twenty female rabbits of Japanese white breed used for 8 weeks. The results obtained from this study may be summarized as follows: 1. There was found a highly significant difference(P<0.01) for daily gain weight between treatments. T₂lot with 14.68g and T₂lot with 13.17g had higher daily gain weight than its of control lot. But T₃lot had lower daily gain weight than its of control lot. 2. In feed consumption there were highly significant differences (P<0.01) between treatments and sex. T₂lot and T₁lot had more feed intake than its of control lot. But T₃lot had lower feed intake than its of control lot. 3. The difference in feed conversion was found insignificant between treatments.

캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예

송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.

11세 여아에서 발생된 성숙 낭성 기형종의 염종1예

이희민,김재현,이봉주,하태규,김흥곤,윤기중 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.1

Mature cystic teratomas comprise 10% of all ovarian tumors and show the highest frequency of incidence in women under 20 years of age. Torsion of ovarian cyst is the most common complication in young female and lower abdominal pain, peritonitis, necrosis and shock are outcomes that require emergency treatment. Generally, gross finding of mature cystic teratoma shows that most of the entire ovary is replaced by multiple cystic masses, and rarely only small portion of the ovary is changed into cystic mass. We report a case of torsion of mature cystic teratoma in an 11 year old girl with a brief review of literature.