사매가 Ovalbumin감작으로 유발된 천식 생쥐 모델에서 기관지염증 억제에 미치는 영향

임중근,노성수,길기정,이영철,서영배 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Asthma is a chronic inflammatory disease of the airways, characterized by airway eosinophilia, goblet cell hyperplasia with mucus hypersecretion, and hyper-responsiveness to both inhaled allergens and nonspecific stimuli. Eosinophil are important in the pathogenesis of asthma, with release of inflammatory mediators such as histamine, leukotrienes, cytokines, and IgE after exposure to allergen. Objectives : This research investigates the effect of the extract of Duchesnea chrysanta (EDC) on OVA-indued asthma murine model. Methods : After i.p of C57BL/6 mice, OVA sensitization (day 0) were challenged intratracheally with OVA on days 8 and 21. EDC administered weeks 8, blocked the airway inflammatory response to OVA assessed 24 h after the last OVA challenge on day 22. Results : The CC chemokine receptor 3 (CCR3) is expressed by eosinophils, mast cells, and Th2 cells. The role of CCR3 in a murine model of allergic skin inflammation induced by repeated epicutaneous sensitization with ovalbumin (OVA), and characterized by eosinophil skin infiltration, local expression of Th2 cytokines, and airway hyperresponsiveness (AHR) to inhaled antigen. The administration of EDC during OVA inhalation significantly reduced CCR3 plays an essential role in eosinophil recruitment to the skin and the lung and in the development of AHR.. EDC extract reduced total lung cells and eosinophils in bronchoalveolar lavage fluid, airway tissue eosinophilia, goblet cell hyperplasia, mucus secretion, and peribronchial edema. The inhibitory effect on airway eosinophilia and AHR was associated with reduced levels of IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid as well as reduced serum levels of OVA-IgE. We show that OVA inhalation following OVA immunization increased airway responsiveness to induced IL-113, IL-4 and IL-5 mRNA expression in the lung tissue. The administration of EDC during OVA inhalation significantly reduced this increased airway hyperresponsiveness and also inhibited airway inflammation. Conclusions : These results support EDC as a therapeutic target in asthma and indicate that selective EDC inhibitors can reduce allergic airway inflammation.

승모판협착증환자에서의 운동능력 및 운동 후 회복능력 : 경피적풍선판막성형술과 운동치료가 이에 미치는 영향

임희영,이철환,박성욱,김재중,송재관,홍명기,진영수,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

소아의 상부 요관확장증에서 폐쇄 유무 감별에 있어 Tc-99m DTPA 이뇨 신장 신티그램의 유용성

한성태,이재문,손형선,임계연,양기라 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.1

Purpose: The purpose of this study was to evaluate the accuracy of Tc-99m DTPA diuretic renal scans in children upper urinary tract. Materials and Methods: We reviewed diuretic renal scans of 14 pediatric patients (age range: 3 days to 4 years) with unilateral hydronephrosis diagnosed by ultrasonography. Diuretic renal scan was done using Tc-99m DTPA and standardized protocol. In 3 neonates, diuretic renal scans were performed within 1 week and 3-7 months after birth. Results: Six patients required pyeloplasty and eight were managed conservatively. All 6 patients requiring pyeloplasty were diagnosed as having ureteropelvic junction obstruction in the diuretic renal scan. In these 6 patients, post-operative renal scans at 3-12 months after surgery were converted to nonobstructive pattern in 5 and a nonobstructive patterns in 1. In 3 patients who underwent diuretic renal scan within 1 week after birth., nonobstructive patterns of initial scan were coverted to obstructive patterns in the follow-up scan. However, all patients with nonobstructive diuretic renal scans performed after the neonatal period did well on serial ultrasonography and showed favorable clinical outcome without progression to obstruction. Conclusion: Tc-99m DTPA diuretic renal scan with standarized protocol is useful in assessing suspected ureteropelvic junction obstruction in children as an initial diagnostic or post-operative follow-up modality. Nonobstructive or indeterminate scan results in the neonatal period requires follow-up scan to monitor development of the obstructive pattern.

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

소설 인물의 국가ㆍ민족 정체성에 관하여

정충기,임성운 순천대학교 과학교육연구소 2001 科學과 敎育 Vol.9 No.-

Much attention has been paid to the self, its functions and identity in the recent theoretic discussions of literature. This tendency can be seen as a phenomenon of the process of breaking away from the established views on the world, of the disorganization of the views and of groping for various value different from the consciousness of modern ages focusing on reason. The moderns negate a fixed system of thought, pursuing various value. The discussions themselves can be converted into literary themes and contribute to the formation of readers’ nation-state identity. This study is designed to look into how characters perceive and accept their environment. In short, this study is aimed to grasp self-identity before the formation of the subjective consciousness of the novels. This study will gopefully contribute to the effective studies but also by having a right understanding of the characters of the novels.

수산화마그네슘에 의한 배연탈황에 관한 연구

정홍기,장성호,임찬섭,김장호 동아대학교 환경문제연구소 1995 硏究報告 Vol.18 No.2

This study has been carried out to evaluate the effect on desulfurization of flue gas by Mg(OH)₂in steam-power cogeneration plant. We investigated the effects of desulfurizatin on the temperature of flue gas and pH of circulation water in aborber. The desulfurization installations of flue gas in cogeneration and thermoelectric power plant will be increased every year because of stricted environmental regulation in Korea. Some conclusions obtained are summerized as follows ; 1. With regard to running cost, Mg(OH)₂ absorbent for desulfurization of flue gas snowed more economic than Ca(OH)₂. 2. While bunker-C oil with 1.6% sulfur was used, desulfurization of flue gas by Mg(OH)₂ was performed and then SO₂ content in the exhausted gas was under 50 ppm. 3. In flue gas desulfurization, the optimum condition on the temperature and pH was 55-60℃ and 6 respectively, then efficiency was 96%.

소아에서 출혈을 동반한 단일 연소성 용종의 내시경적 절제술

김준기,조상욱,신성하,고영춘,최정영,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.3

일부 산업재해 환자들에서 외상후 스트레스장애

최경숙,임채기,최재욱,강성규,염용태 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.3

연구목적 : 우리나라에서 산업 재해로 신체적 손상을 입고 입원해 있는 일부 근로자들을 대상으로 PTSD 발병여부를 조사하고, 산업 재해와 관련된 위험 인자를 파악하여 산업재해 이후 근로자들이 겪게 될 신체적 건강문제 뿐만 아니라 정신적 건장 문제 회복에 도움을 주고자 하였다. 방 법 : 2000년 7월에서 2000년 9월 사이에 산업 재해로 인해 신체적인 부상을 입고 입원 중인 인천 소재 산재병원의 남성 입원환자 47명을 대상으로 PTSD 발병여부와 관련 인자를 연구하기 위하여 구조화된 설문 조사와 CAPS를 이용한 진단적 면담을 시행하였다. 결 과 : CAPS를 이용한 면접조사 결과 최종 연구 대상자 47명중 12명(25.5%)이 PTSD로 나타났으며, 모두 증상의 지속 기간이 3개월 이상인 만성 외상후 스트레스장애로 분류되었다. PTSD군 12명과 non-PTSD군 45명을 비교한 결과 BDI, STAI-I, STAI-II, IES 점수는 PTSD 군에서 유의하게 높게 나타났다. 또한 SCR-90-R의 세부항목 중 편집 사고를 나타내는 PAR 점수가 유일하게 두 군 사이에 유의한 차이를 보이지 않았고 그 외의 항목들은 PTSD 군에서 유의하게 높았다. 산재 관련 위험 인자의 비교에서 환자가 주관적으로 보고한 의식의 상실 경험만이 PTSD군에서 유의하게 높게 나타나 이전의 다른 연구자와 일치된 소견을 보였다. 결 론 : 이상의 결과는 산재 사고 이후에 PTSD가 발생하고, 증상이 장기간 지속되어 만성화를 겪을 가능성이 있다는 것을 보여준다. 위험 인자 중에서 사고 관련 위험 인자로 의식의 상실에 대한 주관적인 보고만이 관련성이 있는 것으로 나타났으나, 그 외의 다른 인자들은 관련서이 없는 것으로 나타났다. 그러나 여러 가지 연구의 제한점이 많으므로 연구 시점을 달리하고 많은 대상자를 포함한 후속 연구를 시행해야 산업재해와 PTSD에 대한 이해를 높일 수 있을 것으로 사료된다. Objectives : This study was conducted to assess the development of posttraumatic stress disorder(PTSD) after occupational physical injuries and the risk factors in occupational accident patients for PTSD. Methods : Forty-seven occupational accident patients with physical injuries were administered BDI. STAI I and II, SCL-90-R, IES and questionnaires for risk factors and Clinician-Administered PTSD Scale(CAPS). Results : 1) 12 patients(25%) were diagnosed as PTSD. 2) The BDI, STAI I and II and IES scores are significantly high(<0.05) in PTSD group than non-PTSD group. 3) The subscales of SCL-90-R, with an exception of PAR subscale, showed higher scores(<0.05) in PTSD group. 4) The loss of consciousness(LOC) was only significant risk factor in the occupational accident related factors(<0.05). Conclusion : The results of this study show the development of PTSD among occupational accident patients. The loss of consciousness(LOC) was the only significant risk factor for PTSD in occupational accident patients.

현행 중학교 과학 실험·실습교육에 대한 교사들의 견해와 개선방안

이윤종,기우항,김영호,정원우,양승영,강용희,안병호,임성규,윤일희,김중욱,강동진 경북대학교 과학교육연구소 1996 科學敎育硏究誌 Vol.20 No.-

The status of facilities, management of the experiment, practices, and Science education teaching method in middle school have been investigated. The present status and reasonable management of middle school science education have been grasped from the questionaires. The results are as follows : The reasonable management for expeiments and practices of science education were scanty in the middle school around the urban and rural schools owing to the shortage of facilities and equipments, crowded class, excessive classes, work for teachers, excessive contents of present textbook and insufficience of administrative support etc. The current teaching method of middle school science has emphasized knowledge. This fact does not satisfy the objective of learning due to lack of teaching method. Desirable directions for the improvement of present status of middle school science education were proposed in this paper.

동종 조혈모세포이식 후 발생한 크립토콕쿠스 척추염 1예

고윤호,임동준,이성수,조유경,이동건,최정현,김유진,민창기,김동욱,박정미,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7∼10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome□ (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.(Korean J Infect Dis 33:298∼301, 2001)