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Tahira, Bibi,Asif, Muhammad,Khan, Samiullah,Hussain, Abrar,Shahwani, Muhammad Naeem,Malik, Arif,Inayatullah, Syed,Iqbal, Zafar,Rasool, Mahmood Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome. Materials and Methods: A total of 51 CML patients were recruited in this study. Complete blood counts of all CML patients were performed to find out their total leukocytes, hemoglobin and platelets. FISH was performed for the detection of BCR-ABL fusion and cryptogenic tests using bone marrow samples were performed for the conformation of Ph (9;22)(q34;q11) and variant translocation mechanisms. Results: In cytogenetic analysis we observed that out of 51 CML patients 40 (88.9%) were Ph positive and 4 (8.88%) had Ph negative chromosomes. Mean values of WBC 134.5 $10^3/{\mu}l$, hemoglobin 10.44 mg/dl, and platelets 288.6 $10^3/{\mu}l$ were observed in this study. Conclusions: In this study, Ph positive translocation between chromosome (9:22)(q34;q11) were observed in 40 (88.9%) CML patients.
Akbar, Ali,Bhatti, Abu Bakar Hafeez,Niazi, Samiullah Khan,Syed, Amir Ali,Khattak, Shahid,Raza, Syed Hassan,Kazmi, Ather Saeed Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: Limited data are available regarding the impact of time duration between chemoradiation (CRT) and surgery on pathological complete response (PCR). A PCR translates into better overall and disease free survival. The objective of this study was to determine effect of time duration on outcome after preoperative CRT in rectal cancer. Materials and Methods: A retrospective review of patients undergoing operations for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided in two groups: Group 1 underwent surgery in ${\leq}8weeks$ post neoadjuvant CRT and Group 2 after 8 weeks. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year overall survival and disease free survival was calculated using Kaplan Meier curves and significance was determined using the log rank test. Results: There were 66 patients in group 1 and 93 in group 2. No significant difference in PCR was observed between the two. However, estimated 5 year DFS was significantly higher in Group 1 (66.7%) as compared to Group 2 (53.8%) (P=0.04). Estimated overall 5 year overall survival was not significantly different at 68.2% versus 54.3% (P= 0.09). Conclusions: Delaying surgery more than 8 weeks after preoperative CRT does not impact for PCR in rectal cancer.
Sadaf sajjad,Amjad Sultan,Muhammad Farhanullah Khan,Imam Din Keerio,Muhammad Samiullah Channa,Muhammad Faheem Akbar 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.2
Studies on the biology, life table parameters, and functional response of the green lacewing, Chrysoperlacarnea, were carried out on papaya mealybug, Paracoccus marginatus, under laboratory conditions. Thehighest larval survival rate (90.50%) was recorded on S. cerealella and then on P. marginatus (85%). Thehighest life table values of C. carnea, lx (0.91), R0 (106.45), T (50 days), Mx (263), and rm (0.10), wererecorded on S. cerealella, whereas doubling time (6.95) and death rate (0.11) were recorded onP. marginatus. The 1st instar of C. carnea to both nymphal instars of P. marginatus exhibited type IIfunctional response, whereas the 2nd and 3rd instars exhibited type III functional response. Predatorssuch as C. carnea with type III functional response to P. marginatus are recognized as an effectual biologicalcontrol agent as it can efficaciously establish and manage the P. marginatus population.