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Vandarith Nov,Le Phuong Nguyen,Kennedy Mensah Ose,이혁민,용동은,이경원 대한임상미생물학회 2021 Annals of clinical microbiology Vol.24 No.4
Background: Environmental sanitation plays a significant role on the prevalence ofenteropathogenic bacteria. This study aimed to determine the trends in the prevalence andantimicrobial resistance profiles of enteropathogenic bacteria from 2011 to 2019. Methods: A retrospective analysis was performed using data from stool cultures ofSalmonella spp., Shigella spp., Plesiomonas shigelloides , Yersinia spp., Vibrio spp., andCampylobacter spp. Samples were obtained between 2011 and 2019 from SeveranceHospital. Antimicrobial susceptibility profile was determined using the disk diffusion methodfor nontyphoidal Salmonella (NTS) and Campylobacter spp., following the Clinical andLaboratory Standards Institute (CLSI) guidelines. Results: The number of specimens obtained for stool culture increased significantly from13,412 during the period of 1969–1978, to 48,476 over the past nine years (2011–2019),whereas the ratio of positive specimens decreased significantly from 1,732 (12.9%) to 449(0.9%). The proportion of samples positive for Salmonella Typhi decreased from 472 (93.6%,1969–1978) to 4 (1.5%, 2011–2019), whereas the proportion of NTS increased from 14 (2.8%,1969–1978) to 261 (96.7%, 2011–2019). Among all the enteropathogenic bacteria isolated,Shigella spp. accounted for 60.0% (1,039) isolates from 1969 to 1978, but only 1.6% (7) from2011 to 2019. Campylobacter was the second most prevalent enteropathogenic bacteria,accounting for 29.4% isolates (132). Among the NTS strains isolated from 2016 to 2019, theirsusceptibility rates to ampicillin and sulfamethoxazole-trimethoprim were 51.1% and 85.2%,respectively. Additionally, the susceptibility rate of Campylobacter to ciprofloxacin was 15.8%. Conclusion: The prevalence of Salmonella Typhi and Shigella spp. significantly decreased,whereas those of NTS and Campylobacter spp. increased. Therefore, continuous monitoringof ciprofloxacin-resistant Campylobacter spp. is of vital importance.