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Matrine Suppresses Pancreatic Fibrosis by Regulating TGF-β/Smad Signaling in Rats
Pi Liu,Luhong Zhu,Guohui Zou,Huajing Ke 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.1
Purpose: This study aimed to elucidate the molecular mechanisms of the anti-pancreatic fibrosis effects of matrine in rats. Materials and Methods: Trinitrobenzene sulfonic acid was administrated to rats to establish a pancreatic fibrosis model. Rats weredivided into four groups: Control, Sham, Model, and Matrine (n=8). Hematoxylin-eosin staining, Masson staining, and Azan stainingwere performed to evaluate pancreatic fibrosis. Expression of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin(α-SMA), and collagen I in pancreatic tissues was evaluated by immunohistochemical staining. mRNA and protein levels of TGF-βreceptor 1 (TβR1), TβR2, and Smad2 in pancreatic tissues were determined by RT-PCR and Western blot, respectively. Results: In the model group, hyperplasia of glandules around the glandular ducts, mitochondrial swelling of acinous cells, andsevere fibrosis were found. Interestingly, in the Matrine group, mitochondrial swelling was only found in a small number of acinouscells, and the fundamental structures of pancreatic tissues were intact. Moreover, pancreatic fibrosis was markedly alleviated. Comparing to the Sham group, expression of α-SMA, TGF-β1, and collagen I was sharply elevated in the Model group (p<0.05);however, their expressions were much lower in the Matrine group, compared to the Model group (p<0.05). Compared with theSham group, mRNA and protein levels of Smad2, TβR1, and TβR2 in the Model group were notably raised (p<0.05). However,their high expression was significantly downregulated in the Matrine group (p<0.05). Conclusion: Matrine suppressed pancreatic fibrosis by regulating TGF-β/Smad signaling in rats.
( Xing Long Wang ),( Li Liu ),( Si Xiu Liu ),( Xiao Qing Sun ),( Zhong Xiang Deng ),( Yan Pi ),( Xiao Fen Sun ),( Ke Xuan Tang ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.5
A new CRT binding factor (CBF) gene designated Cbcbf25 was cloned from Capsella bursa pastoris, a wild grass, by the rapid amplification of cDNA ends (RACE). The full-length cDNA of Cbcbf25 was 898 bp with a 669 bp open reading frame (ORF) encoding a putative DRE/CRT (LTRE)-binding protein of 223 amino acids. The predicted CbCBF25 protein contained a potential nuclear localization signal (NLS) in its N-terminal region followed by an AP2 DNA-binding motif and a possible acidic activation domain in the C-terminal region. Bioinformatic analysis revealed that Cbcbf25 has a high level of similarity with other CBF genes like cbfl, cbf2, and cbf3 from Arabidopsis thaliana, and Bncbf5, Bncbf7, Bncbfl6, and Bncbfl7 from Brassica napus. A cold acclimation assay showed that Cbcbf25 was expressed immediately after cold triggering, but this expression was transient, suggesting that it concerns cold acclimation. Our study implies that Cbcbf25 is an analogue of other CBF genes and may participate in cold-response, by for example, controlling the expression of cold-regulated genes or increasing the freezing tolerance of plants.
Maiping Yang,WeiQu Liu,Liyan Liang,Chi Jiang,Yankun Xie,Hongyi Shi,Fengyuan Zhang,Ke Pi 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
In this paper, various fabrics with good self-cleaning performance were prepared via a facile dip-coating method. The fabrics composed with different fibers and woven techniques were firstly immersed in ZnO sol to increase the surfaceroughness, then dip-coated in fluoroalkylsilane (HFT) solution to reduce the surface energy. The coated fabric showedexcellent superhydrophobicity with a water contact angle (WCA) of 157.8 o and water shedding angle (WSA) of 5 o. Themorphologies and chemical compositions of prepared fabrics were observed with SEM, XPS and EDS. The obtained fabrickept stable water-repelling property in acidic and alkaline solutions, solvents and UV irradiation. Benefited from its high antiwaterability and photocatalysis function of ZnO, the coated fabric demonstrated excellent self-cleaning performance. Thisversatile approach of constructing superhydrophobic fabrics is attractive and could be large-scaled employed in industrialproduction process.
Xu, Xiao-Hua,Peng, Xue-Hong,Yu, Ping,Xu, Xiao-Yuan,Cai, Er-Hui,Guo, Pi,Li, Ke Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality.