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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly
Yoshiko Fukuyama,Yorihiko Ikeda,Junichiro Ohori,Gen Sugita,Kazuyoshi Aso,Keiko Fujihashi,David E. Briles,Jerry R. McGhee,Kohtaro Fujihashi 대한면역학회 2015 Immune Network Vol.15 No.1
Streptococcus pneumoniae (the pneumococcus) causes amajor upper respiratory tract infection often leading to severeillness and death in the elderly. Thus, it is important toinduce safe and effective mucosal immunity against thispathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosalIgA antibody responses in older individuals. A combindnasal adjuvant consisting of a plasmid encoding the Flt3 ligandcDNA (pFL) and CpG oligonucleotide (CpG ODN) successfullyenhanced S. pneumoniae-specific mucosal immunityin aged mice. In particular, a pneumococcal surfaceprotein A-based nasal vaccine given with pFL and CpG ODNinduced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNAadjuvant offers an attractive potential for protection againstthe pneumococcus in the elderly.
A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly
Fukuyama, Yoshiko,Ikeda, Yorihiko,Ohori, Junichiro,Sugita, Gen,Aso, Kazuyoshi,Fujihashi, Keiko,Briles, David E.,McGhee, Jerry R.,Fujihashi, Kohtaro The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.1
Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.