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Self-assembly of Glyco-based Polymers for Biomedical Applications
Kazunari Akiyoshi 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
The biologics such as proteins and nucleic acids are attracting attention as innovative next-generation pharmaceutical products. We have developed various bio-inspired nanocarriers based on nanogel engineering, proteoliposome engineering and exosome engineering for biologics delivery in drug delivery system (DDS) and tissue engineering. A new methodology (nanogel tectonics) was proposed for constructing functional gels by controlling the association of self-assembled nanogels as building blocks, and apply them as biomaterials. Polymer vesicles represent potentially suitable compartments for nanofactories that can accumulate at disease sites in the body, where encapsulated enzymes would convert toxic materials into harmless compounds or transform inert prodrugs into cytotoxic compounds. We found a polymeric vesicle of glyco-based polymer (poly (propylene oxide) (PPO)) with an intrinsically permeable bilayer membrane as new enzyme nanoreactors. A new approach for enzyme prodrug cancer therapy have been proposed using bio-transporting nanofactories.
Biodegradable Nanogel-Integrated Hydrogels for Sustained Protein Delivery
Asako Shimoda,Kazunari Akiyoshi,Yuka Yamamoto,Shin-ichi Sawada 한국고분자학회 2012 Macromolecular Research Vol.20 No.3
Polysaccharide nanogel-crosslinked hydrogels for sustained protein delivery systems were prepared using acryloyl group-modified cholesterol-bearing pullulan (CHPOA) as a building block and multiarmed poly(ethylene glycol) (PEGSH) with thiol groups as a cross-linker. Immobilized nanogels were released by the cleavage of ester bonds between the nanogels and cross-linkers according to environmental factors such as pH and the presence of serum. Fluorescein-isothiocyanate-labeled insulin (FITC-Ins)-containing hydrogel was prepared by the cross-linking of FITC-Ins-complexed nanogel and PEGSH. The protein-complexed nanogels were gradually released from the hydrogel by hydrolysis, and then the proteins in the nanogel were released by exchange reactions in the presence of bovine serum albumin. The CHPOA-PEGSH hydrogel is useful as a sustained protein delivery system.