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Ajiboye Basiru Olaitan,Oyinloye Babatunji Emmanuel,Essien Precious Ekong,Onikanni Sunday Amos,Ojo Oluwafemi Adeleke,Kappo Abidemi Paul 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.1
Purpose The ameliorative potential of aqueous leave extract of Sterculia tragacantha on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats were assessed. Methods Forty albino rats (out of fifty) were intraperitoneally induced using 35 mg/kg of streptozotocin, and then grouped into normal control, diabetic control, diabetic animals received 150 and 300 mg/kg of aqueous extract of S. tragacantha leaves (AESTL) and diabetic animals placed on 200 mg/kg of metformin. This experiment lasted for two weeks, animals were sacrificed, and a series of biochemical indices were evaluated. Results Diabetic rats receiving AESTL revealed a momentous decline in fasting blood glucose, urea, creatinine, uric acid, and alkaline phosphatase levels. Administration of AESTL to diabetic animals considerably improved the activities of SOD, CAT, GPx, GST, and GSH with a decline in MDA levels. Also, AESTL reversed abnormalities in mRNA gene expressions of IL-1β, TGF-1β, KIM-1, EPO and CASP 6 in diabetic rats placed on AESTL treatment. The excellent results of diabetic rats maintained on AESTL were supported by histological findings in this study. Conclusion Hence, AESTL may have beneficial effects in controlling nephropathy associated with diabetes mellitus.