골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

중량물 운반시 잡기유형에 따른 근전도 분석

이훈식,강영택,윤양진,정미라,유국종,서국웅,김정태 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this study was to examine EMG changes of the body according to method the holding during carrying object. The experiments were conducted with utilizing EMG analyses for five male and five female adults as subjects. The results were as followed. 1. The higher muscle action potential of vertical holding was shown than that of right holding when carrying objects in MMH work in proportion to the weight of the object. The came from the subjects using their brachial muscles much to maintain the angles of their wrist joints and elbow joints for keeping their stable postures while walking. 2. The higher muscle action potential of right holding was shown in right and left elector-muscles of their spines(L1-L2, L4-L5) while carrying in all stages of weights except 25kg objects than that of vertical holding. These results were caused from more use of brachial muscles than elector-muscles of spines in carrying weight objects. So vertical holding is more effective in carrying weight objects at a short distance than right holding.

자연기흉의 임상적 고찰

이정헌,서강석,김종근,윤영국 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

Spontaneous pneumothorax is an accumulation of air in the pleural space with collapse of the lungs in the absence of external chest trauma. In this study, 175 cases of spontaneous pneumothorax experienced at emergency room of Kyungpook University Hospital from July 1995 to June 1996 were analyzed retrospectively. The results were summarized follows: 1. Sex ratio of male to female was 6.6:1 and the mean age was 36.7 years. 2. In clinical symptoms, dyspnea was 85 cases(48.6%), chest pain 67 cases(38.3%), chest discomfort 18 cases(10.3%), coughing 2 cases(1.1%), and others 3 cases(1.7%). 3. In etiology of spontaneous pneumothorax, primary spontaneous pneumothorax was 118 cases (67.4%) and secondary spontaneous pneumothorax 57 cases(33.6%). The underlying pathologic lesion of secondary spontaneous pneumothorax showed pulmonary tuberculosis in 50 cases(28.6%), COPD in 5 cases(2.9%), bronchial asthma in 1 case(0.6%), and pneumoconiosis in 1 case(0.6%). 4. The incidence of recurrence was as follows; no previous history in 123 cases(70.3%), second attack in 35 cases(20.0%), third attack in 15 cases(8.6%), fourth attack in 1 case(0.6%), and fifth attack in 1 case(0.6%). 5. The interval of recurrence after last attack was as follows; less than 6 months in 36 cases(69.2%), between 6 minths and 1 year in 5 cases(9.6%), between 1 and 2 years in 3 cases(5.8%), between 2 and 3 years in 2 cases(3.8%), and greater than 3 years in 6 cases(11.5%). 6. In distribution of the lesion sites, left was 93 cases(53.1%), right 80 cases(45.7%), and bilateral 2 cases(1.1%). 7. In degree of lung collapse, 17 cases(9.7%) were small(<20%), 127 cases(72.6%) moderate(20-40%), and 31 cases(17.7%) large(>40%). 8. The accompanied diseases of spontaneous pneumothorax were found in 17 cases, in which hydrothorax were 14 cases and homothorax were 3 cases. 9. The employed management were as follows; bed rest with oxygen inhalation in 6 cases(3.4%), thoracentesis in 4 cases(2.3%), closed thoracostomy in 136 cases(77.7%), and open thoracotomy in 29 cases(16.6%). 10. The reexpansion time after chest tube insertion was as follows; less than 1 day in 147 cases(89.6%), between 1 and 2 days in 12 cases(7.3%), between 2 days and 1 week in 4 cases(2.4%), and greater than 1 week in 1 case(0.6%). 11. The duration of chest tube insertion was as follows; less than 1 week in 102 cases(62.2%), between 1 and 2 weeks in 34 cases(20.7%), between 2 and 3 weeks in 14 cases(8.5%), between 3 and 4 weeks in 7 cases(4.3%), and greater than 4 weeks in 7 cases(4.3%). 12. The complications of closed thoracostomy were as follows; incomplete lung expansion in 4 cases and empyema in 1 case. 13. The indications of open thoracotomy were as follows; bleb or bullae on chest X-ray in 12 cases(14.4%), persistent air leak in 8 cases(27.6%), recurrent pneumothorax in 4 cases(13.8%), incomplete lung expansion in 3 cases(10.3%), and contralateral pneumothorax history in 2 cases(6.9%). 14. The duration of hospitalization was as follows; less than 1 week in 100 cases(57.1%), between 1 and 2 weeks in 29 cases(16.6%), between 2 and 3 weeks in 22 cases(12.6%), between 3 and 4 weeks in 9 cases(5.1%), and greater than 4 weeks in 15 cases(8.6%).

AO/DI 인터넷 서비스 도입을 위한 트래픽 분석 연구

이강원,국광호,정광재,김태일 한국경영과학회 2000 韓國經營科學會誌 Vol.25 No.3

Based on the results of the internet service survey, the traffic demand forecasts of the AO/DI internet service and N-ISDN service have been performed for each channel (B-channel and D-channel). These traffic forecasts can be used as useful input data for investigating packet processing capacity of the TDX-10A switching system and suggesting guideline for capacity increasement.

乳固形分의 농도에 다른 乳酸菌의 生育

姜國熙,李春花 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

Influence of Solid-Not-Fat concentration on the growth of lactic acid bacteria was investigated in skim milk medium. The cultivation at optimum temperature of each strains was not significant with the various concentration of SNF 10%, 13%, 16%. The viable cell counts of Lac. bulgaricus and Lac. helveticus reached to maximum level of 10^9/ml in 24 hrs incubation and did not counted in 5 days incubation at 40℃. When the cultures (10^9/ml) stored at 30℃, viable cells remained 10^7-8/ml in 7 days. Survival of Lac. acidophilus culture was sustained high level at its optimum temperature for 7 days.

Limulus Amoebocyte Lysate법에 의한 원유와 살균유의 세균수 측정

姜國熙,王智怨,朴興洙,李圭鍾,金敬民 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2

LAL method for the determination of Gram-negative bacterial Lipopolysaccharides(LPS) in milk is proposed and its value for bacteriological quality control is investigated. The relationship between the LPS contents and total colony count(cfu/ml), which covers the Gram-negative bacteria, was determined in raw milk samples. The coefficient of correlation between Gram-negative bacterial counts(cfu/ml) and LPS contents was r^2 =0.969. And, the correlation coefficient between total bacterial counts(cfu/ml) and LPS contents was r^2 =0. 914. It was also investigated how much the LPS contents were in UHT milks from l0 different dairy industrial companies in Korea. It varied from 92 ng LPS/ml to 938 ng LPS /ml.

Streptococcus faecalis var. liquefaciens 의 Plasmid 와 변이주 형질의 연관성

姜國熙,李命基,金榮勳,李春花,朴淵姬 成均館大學校 科學技術硏究所 1986 論文集 Vol.37 No.2

Lac^- and Prt^- variants were selected from Str. faecalis var. liquefaciens SKD-1007 by acrifiavin treatment. Prt^- Lac^- variant was obtained from Prt^- vaiant by mitomycin C treatment. The plasmid of variants showed same pattern with parent strain. Plasmid cured variants(SKR1, SKR2, SKR3) were obtained from parent treated by novobiocin. SKR3 variant which lost pSK6 plasmid(2.1 Mdal) was sensitive to lincomycin and erythromycin. The results implied that pSK6 plasmid of test strain was associated with antibiotic resistance (L.M, EM).

GOS가 장내 Bifidobacteria의 생육촉진에 미치는 영향에 관한 연구

강국희,문지웅,강대중,이재영 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2

We investigated the growth effect of various sugars on the principal intestinal microorganisms which were Bifidobacteria, Lactobacilli, Streptococci, Clostridia, Escherichia, Eubacteria, and Staphylococci. Those microorganisms were cultivated on media containing various sugars. The sugars were grouped into A, B, and C. Group A consisted of sugars extracted by water, 5%, 15%, 30%, and 40%, EtOH, respectively. Group B were galactooligosaccharide(GOS), fructooligosaccharide(FOS), isomaltooligosaccharide(IMO), and xylooligosaccharide( XOS). Group C were LOS, SOS, and LSOS. Bif. adolescentis, Bif. bifidum, Bif. infantis, Bif. longum, and Str. faecalis grew well on the media containing sugars of each A, B, and C group, while C. butyricurm, S. aureus, Eu. limosum, and E. coli did not. The results indicated that oligosaccharides of A, B, and C group were consumed effectively by Bifidobacterium spp. but not utilized by other intestinal microorganisms. Oligosaccharides of each A, B, and C group promoted selectively the growth of Bif. infantis and Bif. longum in the human intestinal microflora.

한국 여성의 유방암 발병에 있어 Methylenetetrahydrofolate Reductase(MTHFR) 유전자 다형성과 식이 간의 상호 관련성

이상아,김동현,유근영,안세현,노동영,조국진,강대희 대한암예방학회 2002 Journal of cancer prevention Vol.7 No.3

α-Galactosidase 에 의한 Bifidobacteria 균수 측정에 관한 연구

강국희,이시경,백운화,민해기 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

This method using the synthesis substrate of 5-bromo-4-chloro-3 indolyl-galactoside (X-a -Gal) was examined for the differential enumeration of Bifidobacteria and lactic acid producing bacteria. Bifidobacteria possess a high level of a-galactosidase activity. Bifidobacterium longum KCTC 3215 exhibited the highest a- galactosidase specific activity (8.57 units/mg protein). Determination of a -galactosidase activity using the PNPG procedure showed that Lactobacillus, Streptococcus, Pediococcus, and Leuconostoc strain had lower a-galactosidase activity as compared to Bifidobacteria. The X-a- Gal based medium is useful to identify Bifidobacteria among lactic acid producing bacteria since the enzyme action of a-galactosidase hydrolysis X-a-Gal substrate and releases indol which impacts a blue color to Bifidobacterial colonies on agar plates. All strains of Bifidobacteria appeared blue colonies on MRS agar medium supplemented with 100 uM X- a - Gal while colonies of other lactic acid producing bacteria appeared white or light blue.