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      저자 : Kang Eawha (검색결과 1 건)
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        Vaccine Effect on Household Transmission of Omicron and Delta SARS-CoV-2 Variants

        김용찬,김봉영,손낙훈,Heo Namwoo,Nam Yooju,Shin Areum,Yang Andrew Jihoon,김민형,Kyong Taeyoung,Kang Eawha,Park Yoon Soo,김희정 대한의학회 2023 Journal of Korean medical science Vol.38 No.1

        Background: We evaluated the household secondary attack rate (SAR) of the omicron and delta severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, according to the vaccination status of the index case and household contacts; further, in vaccinated index cases, we evaluated the effect of the antibody levels on household transmission. Methods: A prospective cross-sectional study of 92 index cases and 197 quarantined household contacts was performed. Tests for SARS-CoV-2 variant type and antibody level were conducted in index cases, and results of polymerase chain reaction tests (during the quarantine period) were collected from contacts. Association of antibody levels in vaccinated index cases and SAR was evaluated by multivariate regression analysis. Results: The SAR was higher in households exposed to omicron variant (42%) than in those exposed to delta variant (27%) (P = 0.040). SAR was 35% and 23% for unvaccinated and vaccinated delta variant exposed contacts, respectively. SAR was 44% and 41% for unvaccinated and vaccinated omicron exposed contacts, respectively. Booster dose immunisation of contacts or vaccination of index cases reduced SAR of vaccinated omicron variant exposed contacts. In a model with adjustment, anti-receptor-binding domain antibody levels in vaccinated index cases were inversely correlated with household transmission of both delta and omicron variants. Neutralising antibody levels had a similar relationship. Conclusion: Immunisation of household members may help to mitigate the current pandemic.

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