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Expression of Transthyretin during bovine myogenic satellite cell differentiation.
Pokharel, Smritee,Kamli, Majid Rasool,Mir, Bilal Ahmad,Malik, Adeel,Lee, Eun Ju,Choi, Inho Springer 2014 In vitro cellular & developmental biology Animal Vol.50 No.8
<P>Adult myogenesis responsible for the maintenance and repair of muscle tissue is mainly under the control of myogenic regulatory factors (MRFs) and a few other genes. Transthyretin gene (TTR), codes for a carrier protein for thyroxin (T4) and retinol binding protein bound with retinol in blood plasma, plays a critical role during the early stages of myogenesis. Herein, we investigated the relationship of TTR with other muscle-specific genes and report their expression in muscle satellite cells (MSCs), and increased messenger RNA (mRNA) and protein expression of TTR during MSCs differentiation. Silencing of TTR resulted in decreased myotube formation and decreased expression of myosin light chain (MYL2), myosin heavy chain 3 (MYH3), matrix gla protein (MGP), and voltage-dependent L type calcium channel (Cav1.1) genes. Increased mRNA expression observed in TTR and other myogenic genes with the addition of T4 decreased significantly following TTR knockdown, indicating the critical role of TTR in T4 transportation. Similarly, decreased expression of MGP and Cav1.1 following TTR knockdown signifies the dual role of TTR in controlling muscle myogenesis via regulation of T4 and calcium channel. Our computational and experimental evidences indicate that TTR has a relationship with MRFs and may act on calcium channel and related genes.</P>
Lee, E.J.,Lee, H.J.,Kamli, M.R.,Pokharel, S.,Bhat, A.R.,Lee, Y.H.,Choi, B.H.,Chun, T.,Kang, S.W.,Lee, Y.S.,Kim, J.W.,Schnabel, R.D.,Taylor, J.F.,Choi, I. Academic Press 2012 Genomics Vol.100 No.3
We report a systematic study of gene expression during myogenesis and transdifferentiation in four bovine muscle tissues and of adipogenesis in three bovine fat tissues using DNA microarray analysis. One hundred hybridizations were performed and 7245 genes of known and unknown function were identified as being differentially expressed. Supervised hierarchical cluster analysis of gene expression patterns revealed the tissue specificity of genes. A close relationship in global gene expression observed for adipocyte-like cells derived from muscle and adipocytes derived from intramuscular fat suggests a common origin for these cells. The role of transthyretin in myogenesis is a novel finding. Different genes were highly induced during the transdifferentiation of myogenic satellite cells and in the adipogenesis of preadipocytes, indicating the involvement of different molecular mechanisms in these processes. Induction of CD36 and FABP4 expression in adipocyte-like cells and adipocytes may share a common pathway.
Grant Allen’s The Woman Who Did : A Critique on Eugenics and New Womanhood
( Kam¸ Kyeong Yeon ) 동국대학교 영어권문화연구소 2014 영어권문화연구 Vol.7 No.2
This paper, which makes available the forgotten pictures and previously unnoticed complexites drawn from articles, introduces aspects of the work of a neglected naturalist and evolutionist writer of the late nineteenth century in Victorian era. In particular, this paper focuses on Allen's analysis of the social construction of marriage and his concern of the future race and the concomitant issue of motherhood and social progress. On the issue of recognizing and validating women's role as mothers and entitling them public recognition as a social contributor, Allen is in line with early feminists known as eugenic feminists such as Sarah Grand and Frances Swiney. As to the mechanism of evolution, however, Allen differed from their view in that he regarded nature as a driving force whereas eugenic feminist saw human control as the key note in the evolutionary process. Such tension is witnessed in Allen's New Woman Novel, The Woman Who Did (1895) in which the protagonist Herminia seeks women's emancipation through her task of mothering premised on eugenic ideology. Ironizing Herminia's failure and her death, Allen calls into question the practicability of the discourse constituting the eugenic project. Drawing on the theories on evolution and Richardson's concept of “eugenic love”, this paper examines social implication in Herminia's maternal agenda and investigates the condition of her project which is already doomed to fail.
김감래,김명배,한상학 명지대학교 대학원 1999 대학원논문집 Vol.3 No.-
In order to obtain exact location information from the map which has different reference datum, we have to do coordinate transformation from other to reference coordinate system we use. In this paper, in order to evaluate accuracy between two maps have different ellipsoid, it is studied theory of map projection and coordinate transformation. Then, select maps about same area, select points which can be recognized on the maps for accuracy evaluation. After obtain coordinates about the points by TM projection and UTM projection, evaluated accuracy between TM coordinates, after to do Two-dimensional coordinate transformation, and after coordinate transformation from UTM to TM. As a result of this study, the maps which have different reference datum can be used if the exact transformation parameters can be obtained and applied.
황감용,송건섭 大邱大學校 社會科學硏究所 1999 社會科學硏究 Vol.6 No.2
현재까지 지방자치단체에 대한 감사는 대부분이 감사원에 의해 이루어져 왔다. 그러나 감사원에서 시행하고 있는 감사활동에 대한 국민들의 시선은 따갑고, 못 미더워하고 있다. 이는 특정한 사건이 발생하면 '소 잃고 외양간 고치는 식'으로 집중 감사함으로써 예방적·감시적 기능이 미약했기 때문이다. 그러므로 현재 감사원에 의해 주도되고 있는 지방자치단체의 회계감사제도를 한 단계 높이고, 감사인력을 효율적으로 운용하기 위해서는 지방자치단체의 감사기법개발, 지방 전문 감사인력배양, 회계감사기준 정립 등이 요청된다.
金甘來,金周龍,朴世珍 明知大學校 産業技術硏究所 2005 産業技術硏究所論文集 Vol.24 No.-
This paper is study of DEM accuracy evaluation of black & white, negative, positive films by using non-metric camera. Modeling method is used DLT. DEM is produced by image matching. DEM accuracy of black & white film is best. Black & white film compared with digital camera film. So it is not big different. Through the study, its can know value of digital camera usage.
金甘來,鄭海珍,任健爀 明知大學校 産業技術硏究所 2007 産業技術硏究所論文集 Vol.26 No.-
Due to an urbanization phenomenon which is caused according to a large selecting land development of a city area drained by river, the keeping gate phenomenon is changed and the flood damage is happening near city river. Recently, many research to reduce such city flood damage for the prevention have been achieved, this study proposed to analyze and arrange pattern of disaster and systems designed plan and establishment further scientific, prompt service of disaster. With GIS technique for decision-making offer the necessary preliminary data(hydrography data, satellite images, DEM, etc). In order to forecast the flooding area of research object area and offer various information which can reduce the flood damage to many users, this study constructs the disaster management system using Internet GIS.
공공부조의 실태와 방향 : 대구시를 중심으로 A Case of Taegu City
황감용,송건섭,이곤수 大邱大學校 社會科學硏究所 2000 社會科學硏究 Vol.7 No.3
이 연구는 공공부조의 실태를 대구시를 중심으로 분석하고, 운영상의 문제점, 제도와 현실의 괴리 등을 밝혀 시사점을 제공하여 하였다. 분석결과 문제점으로 대상자 선정 및 선정기준이 모호하고 비현실적이라는 점, 보호내용이 미비하고, 보호행정 체계가 부실하다는 점 등이 나타났다. 방향으로는 대상자선정과 보호수준의 개선, 보호내용강화, 보호행정체계의 정비 등은 물론이고, 의료보호 급여수준을 확대하고 사회복지전담요원을 많이 양성하여 확대 배치하는 노력이 필요하다. 특히 시대적 요청에 의해 생활보호법은 폐지되고 새로운 법(국민기초생활보장법)이 제정되어 그 시행을 눈앞에 두고 있다 이 법의 시행으로 그 동안 우려하던 보호대상자 선정기준, 수급권자의 범위, 최저생계비 문제 등은 다소 해결될 것으로 보인다.