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      • KCI등재

        Comparison of amino acid digestibility of soybean meal, cottonseed meal, and low-gossypol cottonseed meal between broilers and laying hens

        Qiu Kai,Wang Xiao-cui,Wang Jing,Wang Hao,Qi Guang-hai,Zhang Hai-jun,Wu Shu-geng 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.4

        Objective: This study aimed to determine and compare the apparent ileal digestibility (AID) and the standardized ileal digestibility (SID) of amino acids (AA) in soybean meal (SBM), cottonseed meal (CSM), and low-gossypol cottonseed meal (LCSM) fed to broiler chickens and laying hens. Methods: Three semi-purified diets containing the identical crude protein concentration at 20% were formulated to contain SBM, CSM, or LCSM as the sole source of N. A N-free diet was also formulated to estimate the basal ileal endogenous losses of AA for broilers and hens. A total of 300 male Ross 308 chicks at one-day-old and 144 Hy-Line Brown laying hens at 30-week-old with initial egg production rate of 88.3%±1.0% were randomly allocated into 1 of 4 dietary treatments, respectively. Results: CSM and LCSM showed more Arg and Cys+Met while less Lys, Ile, Leu, and Thr relative to SBM. Significant interactions existed between species and experimental diets for AID (except for Arg, Asp, Glu, Gly, and Pro) and SID (except for Arg, His, and Phe) of most AA. Most AA in diets showed higher AID (except for Lys) and SID (except for Lys, Met, and Ser) in broilers relative to laying hens. The AID and SID of all AA were significantly different between the three diets. In broilers, the AID and SID of most indispensable AA except for Arg in SBM and LCSM was higher than CSM. In laying hens, the AID and SID of most indispensable AA except for Arg, Met+Cys, and Phe in SBM was higher than CSM and LCSM. Conclusion: The accurate determination of AID and SID of AA in CSM and LCSM for broilers and layers benefits the application of CSM and LCSM in chicken diets. The cottonseed by-products CSM or LCSM showed the species-specific AA digestibility values for broilers and layers.

      • KCI등재

        Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn`s disease

        ( Kai Chun Wu ),( Zhi Hua Ran ),( Xiang Gao ),( Minhu Chen ),( Jie Zhong ),( Jian Qiu Sheng ),( Michael A Kamm ),( Simon Travis ),( Kori Wallace ),( Nael M Mostafa ),( Marisa Shapiro ),( Yao Li ),( Ro 대한장연구학회 2016 Intestinal Research Vol.14 No.2

        Background/Aims: This was a Phase 2 study (NCT02015793) to evaluate the pharmacokinetics, safety, and efficacy of adalimumab in Chinese patients with Crohn`s disease (CD). Methods: Thirty, adult Chinese patients with CD (CD Activity Index [CDAI] 220-450; high-sensitivity [hs]-C-reactive protein [CRP] ≥3 mg/L) received double-blind adalimumab 160/80 mg or 80/40 mg at weeks 0/2, followed by 40 mg at weeks 4 and 6. An open-label extension period occurred from weeks 8-26; patients received 40 mg adalimumab every other week. Serum adalimumab concentration and change from baseline in fecal calprotectin (FC) were measured during the double-blind period. Clinical remission (CDAI <150), response (decrease in CDAI ≥70 points from baseline), and change from baseline in hs-CRP were assessed through week 26. Nonresponder imputation was used for missing categorical data and last observation carried forward for missing hs-CRP/FC values. No formal hypothesis was tested. Adverse events were monitored. Results: Mean adalimumab serum concentrations during the induction phase were 13.9-18.1 μg/mL (160/80 mg group) and 7.5-9.5 μg/mL (80/40 mg group). During the double-blind period, higher remission/ response rates and greater reductions from baseline in hs-CRP and FC were observed with adalimumab 160/80 mg compared to that with 80/40 mg. Adverse event rates were similar among all treatment groups. Conclusions: Adalimumab serum concentrations in Chinese patients with CD were comparable to those observed previously in Western and Japanese patients. Clinically meaningful remission rates and improvement in inflammatory markers were achieved with both dosing regimens; changes occurred rapidly with adalimumab 160/80 mg induction therapy. No new safety signals were reported. (Intest Res 2016;14:152-163)

      • SCIESCOPUS

        Effect of seismic acceleration directions on dynamic earth pressures in retaining structures

        Nian, Ting-Kai,Liu, Bo,Han, Jie,Huang, Run-Qiu Techno-Press 2014 Geomechanics & engineering Vol.7 No.3

        In the conventional design of retaining structures in a seismic zone, seismic inertia forces are commonly assumed to act upwards and towards the wall facing to cause a maximum active thrust or act upwards and towards the backfill to cause a minimum passive resistance. However, under certain circumstances this design approach might underestimate the dynamic active thrust or overestimate the dynamic passive resistance acting on a rigid retaining structure. In this study, a new analytical method for dynamic active and passive forces in c-${\phi}$ soils with an infinite slope was proposed based on the Rankine earth pressure theory and the Mohr-Coulomb yield criterion, to investigate the influence of seismic inertia force directions on the total active and passive forces. Four combinations of seismic acceleration with both vertical (upwards or downwards) and horizontal (towards the wall or backfill) directions, were considered. A series of dimensionless dynamic active and passive force charts were developed to evaluate the key influence factors, such as backfill inclination ${\beta}$, dimensionless cohesion $c/{\gamma}H$, friction angle ${\phi}$, horizontal and vertical seismic coefficients, $k _h$ and $k_v$. A comparative study shows that a combination of downward and towards-the-wall seismic inertia forces causes a maximum active thrust while a combination of upward and towards-the-wall seismic inertia forces causes a minimum passive resistance. This finding is recommended for use in the design of retaining structures in a seismic zone.

      • Effect of FeNi30 Powder Catalyst by Water Atomizing on Synthesis High-grade Diamond

        Cheng Dong-kai,Ma Hong-qiu,Cao Dan,Ding Fu-chang 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

        This paper described the preparation method for composing high-grade synthetic diamond by water atomizing using FeNi30 powder catalyst. The objective of this article is about powder making process using super high water atomizing in the atmosphere of inert gas, and then corroded the powder with a corrosion inhibitor. Finally, FeNi30 catalyst powder with lower oxygen content and good sphericity is produced. The experiment of making diamonds by using cubic press and the performance of the diamonds are also discussed.

      • KCI등재

        Protective effect of liensinine on periodontitis through its antioxidant effect in mice

        Liang Pang,Kai Zhu,Xia Feng,Weiwei Liu,Deguang Peng,Lihua Qiu,Xiang Gao,Jiang Deng,Ying Li,Xin Zhao 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.6

        Liensinine is the most important functional compound in lotus seeds; its protective effect on periodontitis was determined and the mechanism of its antioxidant effect was also explained. During the experiment, we could observe that liensinine could reduce the gingival index in periodontitis-induced mice, and these effects were similar to that during the treatment of periodontitis with the metronidazole drug. After the treatment with liensinine, the serum Immunoglobulin G1 (IgG1) level was found to increase and IgG2a level was found to decrease compared to the periodontitis control mice. Liensinine and metronidazole could increase the superoxide dismutase (SOD) serum levels in the periodontitis-induced mice, and both the drugs at the same concentration (200 mg/kg) showed similar SOD activities, which was found to increase. Liensinine also increased the oxidationrelated factor of catalase (CAT), glutathione peroxidase, and decreased nitric oxide, malondialdehyde, and endothelin in the serum of mice, compared to the periodontitis control mice. The serum cytokine levels of Interleukin-6, tumor necrosis factor-a, and Interferon-c in liensinine-treated mice were lower than the control mice, but higher than the normal mice. The serum IL-4 cytokine level of liensinine-treated mice was reversed, i.e., higher than the control mice. In the periodontal tissue, the mRNA and protein expressions of inhibitor of kappa B-a, transforming growth factor beta 1, Interleukin-10, Mn-SOD, Gu/Zn-SOD, and CAT were increased by the treatment with liensinine compared to the control group mice, and nuclear factor kappa B expressions showed the opposite trend. Liensinine is a good functional compound in the treatment of periodontitis, similar to metronidazole drug. Higher concentration of liensinine had better effects.

      • KCI등재

        UWB Bi-directional Bow-tie Antenna Loaded by Rings

        Lin Peng,Kai Sun,Ji-yang Xie,Yu-jie Qiu,Xing Jiang 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.1

        Performances of bow-tie antennae can be improved by loading a ring. Specially, the distorted radiation patterns of the reference bow-tie antenna (RBA) at high frequencies become less distorted when a ring is added. That is due to the disciplined current flows trained by the ring. Furthermore, when more rings are loaded, which act as reflectors, higher directivities are obtained and, patterns become bi-directional. Antennae with no ring (RBA), one ring, two rings (three cases), three rings, and four rings are investigated. Research find that loading more rings means better directivity. The directivity of the RBA varies from 2.29 dB to 3.66 dB for the frequency band from 2.5 to 7.5 GHz while the directivity for the four-ring-loaded case varies from 4.27 dB to 7.61 dB in that frequency band.

      • Stress variation analysis based on temperature measurements at Zhuhai Opera House

        Lu, Wei,Teng, Jun,Qiu, Lihang,Huang, Kai Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

        The Zhuhai Opera House has an external structure consisting of a type of spatial steel, where the stress of steel elements varies with the ambient temperature. A structural health monitoring system was implemented at Zhuhai Opera House, and the temperatures and stresses of the structures were monitored in real time. The relationship between the stress distribution and temperature variations was analysed by measuring the temperature and stresses of the steel elements. In addition to measurements of the structure stresses and temperatures, further simulation analysis was carried out to provide the detailed relationship between the stress distributions and temperature variations. The limited temperature measurements were used to simulate the structure temperature distribution, and the stress distributions of all steel elements of the structure were analysed by building a finite element model of the Zhuhai Opera House spatial steel structure. This study aims to reveal the stress distributions of steel elements in a real-world project based on temperature variations, and to supply a basic database for the optimal construction time of a spatial steel structure. This will not only provide convenient, rapid and safe early warnings and decision-making for the spatial steel structure construction and operation processes, but also improve the structural safety and construction accuracy of steel space structures.

      • SCIESCOPUS

        Influences of seepage force and out-of-plane stress on cavity contracting and tunnel opening

        Zou, Jin-Feng,Chen, Kai-Fu,Pan, Qiu-Jing Techno-Press 2017 Geomechanics & engineering Vol.13 No.6

        The effects of seepage force and out-of-plane stress on cavity contracting and tunnel opening was investigated in this study. The generalized Hoek-Brown (H-B) failure criterion and non-associated flow rule were adopted. Because of the complex solution of pore pressure in an arbitrary direction, only the pore pressure through the radial direction was assumed in this paper. In order to investigate the effect of out-of-plane stress and seepage force on the cavity contraction and circular tunnel opening, three cases of the out-of-plane stress being the minor, intermediate, or major principal stress are assumed separately. A method of plane strain problem is adopted to obtain the stress and strain for cavity contracting and circular tunnel opening for three cases, respectively, that incorporated the effects of seepage force. The proposed solutions were validated by the published results and the correction is verified. Several cases were analyzed, and parameter studies were conducted to highlight the effects of seepage force, H-B constants, and out-of-plane stress on stress, displacement, and plastic radius with the numerical method. The proposed method may be used to address the complex problems of cavity contraction and tunnel opening in rock mass.

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