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RISS 인기검색어
- 검색키워드
- 저자 : Kai Bin Liew (검색결과 2 건)
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Kai Bin Liew,Kok Khiang Peh 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
Orally disintegrating tablet (ODT) is a userfriendly and convenient dosage form. The study aimed toinvestigate the effect of polymers and wheat starch on thetablet properties of lyophilized ODT, with dapoxetine asmodel drug. Three polymers (hydroxypropylmethyl cellulose,carbopol 934P and Eudragit EPO) and wheat starchwere used as matrix forming materials in preparation oflyophilized ODT. The polymeric dispersion was casted intoa mould and kept in a freezer at -20 C for 4 h beforefreeze dried for 12 h. It was found that increasing in HPMCand Carbopol 934P concentrations produced tablets withhigher hardness and longer disintegration time. In contrast,Eudragit EPO was unable to form tablet with sufficienthardness at various concentrations. Moreover, HPMCseems to have a stronger effect on tablet hardness comparedto Carbopol 934P at the same concentration level. ODT of less friable was obtained. Wheat starch acted asbinder which strengthen the hardness of ODTs and prolongedthe disintegration time. ODT comprising of HPMCand wheat starch at ratio of 2:1 was found to be optimumbased upon the tablet properties. The optimum formulationwas palatable and 80 % of the drug was released within30 min in the dissolution study.
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Cold chain time- and temperature-controlled transport of vaccines: a simulated experimental study
Chun Zheng Ng,Yen Loong Lean,Siang Fei Yeoh,Qi Ying Lean,Kah Seng Lee,Amal Khalil Suleiman,Kai Bin Liew,Yaman Walid Kassab,Yaser Mohammed Al-Worafi,Long Chiau Ming 대한백신학회 2020 Clinical and Experimental Vaccine Research Vol.9 No.1
Purpose: The objective of this research was to examine the cold chain temperature maintenance for the supply of vaccines and other biological products by pharmaceutical wholesaler. Materials and Methods: In this study, six configurations using cold vaccine boxes or bags made with different materials, with and without insulation, of different sizes, and number of coolant-packs were used to simulate the configuration used by the pharmaceutical wholesalers for transportation of vaccine. Model vaccines (vial, n=10) were packed using these six configurations which then stored in an incubator at 38ºC and monitored for 24 hours. Each configuration was tested repeatedly for 5 times. Results: In term of compliance to 2°C–8°C, four out of six tested configurations are effective in cold chain transportation. The effectiveness is highly dependent on the type of passive containers used, size of cold boxes, insulation, and number of coolant-packs. The configuration with a larger polystyrene foam box with five coolant-packs maintained the required temperature up to 23 hours. In contrast, configurations using a polystyrene foam box with four coolant-packs and a large vaccine cold box with two coolant-packs failed to reach below 8ºC throughout the 24 hours. Conclusion: Packaging method, the material and size of the container could have a direct impact on the effectiveness of cold chain temperature maintenance. Polystyrene foam box, cold box with polyethylene interior lining and polypropylene insulation, a cooler bag with proper number of ice packs could be effectively used for
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