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Youngjoo, Kwon,Kyu-Yeon, Jun,Eun-Young, Lee,Mi-Ja, Jung,Ok-Hee, Lee,Eung-Seok, Lee,Hea-Young, Park,Younghwa, Na 이화여자대학교 약학연구소 2012 藥學硏究論文集 Vol.- No.22
Epoxide ring-opened xanthone derivatives were synthesized and tested for their topoisomerase inhibitory activity and cytotoxicity. Most of the compounds showed topo IIα specific inhibitory activity. To clarify the echanism of action of these compounds, the most potent compound (compound 14) of the synthesized analogues was further studied by testing its ATPase inhibitory activity and through molecular docking experiments. The results showed that the topo IIα inhibitory activity of compound 14 was inversely proportional to ATP concentration. In the ATPase inhibitory test, ATP hydrolysis was reduced less efficiently by compound 14 (28.5±4.6%) than novobiocin (60.4±8.1%). Molecular docking study revealed compound 14 to have a stable binding pattern to the ATP-binding domain of human topo II.
KWON, YOUNGJOO 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
The Rev binding to Rev Responsive Element(RRE) of HIV-1 mRNA plays an important role in the HIV-l viral replication cycle. The disruption of the Rev-RRE interaction has been studied extensively in order to develop a potential antiviral drug. In order to provide the basis for a more promising approach to develop a Rev-RRE binding inhibitor against HIV-l infection, it is necessary to understand the binding modes of the aminoglycoside antibiotics to RRE. In the present study, the binding mode of a modified antibiotic, a neamine conjugated with pyrene and arginine (NCPA), to RRE has been studied by the methods of T_(m) measurement and spectroscopic analysis of RRE with or without antibiotics. The results confirmed that NCPA competes with Rev in binding to RRE.
Kwon, Youngjoo,Sohn, Sung-Hwa,Lee, Gihyun,Kim, Youngeun,Lee, Hyejung,Shin, Minkyu,Bae, Hyunsu Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P>A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes. In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated with CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> regulatory T cells (Treg). Cellular profiles and histopathologic analysis demonstrated that peribronchial and perivascular inflammatory cell infiltrates were significantly decreased in the EA-treated groups when compared to the OVA and anti-CD25 Ab-injected (Treg depletion) groups. Furthermore, total BAL cells were reduced in the EA groups when compared to other groups. Interestingly, the population of CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP>Tregs in pneumonocytes increased in EA-treated group when compared to OVA and Treg depletion groups. These results imply that EA stimulation at ST 36 may affect CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg in an OVA-induced experimental model and may enhance Treg function by suppressing other T cells and limiting the immune response.</P>
Curcumin as a Cancer Chemotherapy Sensitizing Agent
Kwon, Youngjoo The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.2
The development of cancer chemotherapy made a significant progress in cancer treatment. However, most chemotherapeutic drugs are challenged by drug resistance and drug-induced toxicity. Combination therapy has been suggested as an effective strategy to avoid drug resistance and reduce toxicity derived from drug, thereby enhancing clinical treatment of cancer. Many food-derived bioactive compounds have exhibited anticancer activity and can be good candidates for combination therapy with existing chemotherapeutic drugs. Curcumin is one of compounds that present anticancer activity in many types of cancer and has been extensively studied for its anticancer mechanisms including inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$) activation. Combinational treatment of curcumin enhanced therapeutic efficacy of traditional chemotherapeutic drugs, cisplatin, doxorubicin, 5-fluorouracil, and gemcitabine. NF-${\kappa}B$ is a major downstream effector that leads to chemoresistance of many therapeutic drugs. Down-regulation of NF-${\kappa}B$ by curcumin is an effective mechanism to sensitize chemotherapeutic drugs and increase therapeutic efficacy. Therefore, combination use of curcumin and available anticancer drugs has great potential to enhance chemotherapy efficacy and improve clinical treatment of cancer. More studies will be required to elucidate cause effect relationship of curcumin-induced suppression of cell survival pathways and enhancement of drug efficacy by curcumin.
Association of curry consumption with blood lipids and glucose levels
Youngjoo Kwon 한국영양학회 2016 Nutrition Research and Practice Vol.10 No.2
BACKGROUND/OBJECTIVES: Curcumin, an active ingredient in turmeric, is highly consumed in South Asia. However, curry that contains turmeric as its main spice might be the major source of curcumin in most other countries. Although curcumin consumption is not as high in these countries as South Asia, the regular consumption of curcumin may provide a significant health-beneficial effect. This study evaluated whether the moderate consumption of curry can affect blood glucose and lipid levels that become dysregulated with age. SUBJECTS/METHODS: This study used data obtained from the Korea National Health and Nutrition Examination Survey, conducted from 2012 to 2013, to assess curry consumption frequency as well as blood glucose and blood lipid levels. The levels of blood glucose and lipids were subdivided by age, sex, and body mass index, and compared according to the curry consumption level. The estimates in each subgroup were further adjusted for potential confounding factors, including the diagnosis of diseases, physical activity, and smoking. RESULTS: After adjusting for the above confounding factors, the blood glucose and triglyceride levels were significantly lower in the moderate curry consumption group compared to the low curry consumption group, both in older (> 45) male and younger (30 to 44) female overweight individuals who have high blood glucose and triglyceride levels. CONCLUSIONS: These results suggest that curcumin consumption, in an ordinary diet, can have health-beneficial effects, including being helpful in maintaining blood glucose and triglyceride levels that become dysregulated with age. The results should be further confirmed in future studies.
Youngjoo Kwon 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.5
BACKGROUND/OBJECTIVES: Turmeric and its active component curcumin have received considerable attention due to their many recognized biological activities. Turmeric has been commonly used in food preparation and herbal remedies in South Asia, leading to a high consumption rate of curcumin in this region. However, the amount of curcumin in the Korean diet has not yet been estimated, where turmeric is not a common ingredient. SUBJECTS/METHODS: This study utilized the combined data sets obtained from the Korea National Health and Nutrition Examination Survey conducted from 2008 to 2012 in order to estimate the curcumin intake in the Korean diet. The mean intake of curcumin was estimated from the amount of curcumin-containing foods (curry powder and ready-made curry) consumed using reported curcumin content in commercial turmeric and curry powders. RESULTS: Only 0.06% of Koreans responded that they consumed foods containing curcumin in a given day, and 40% of them were younger than 20 years of age. Curcumin-containing foods were largely prepared at home (72.9%) and a significant proportion (20.4%, nearly twice that of all other foods) was consumed as school and workplace meals. The estimated mean turmeric intake was about 0.47 g/day corresponding to 2.7-14.8 mg curcumin, while the average curry powder consumption was about 16.4 g, which gave rise to curcumin intake in the range of 8.2-95.0 mg among individuals who consumed curcumin. The difference in estimated curcumin intake by using the curcumin content in curry powder and turmeric may reflect that curry powder manufactured in Korea might contain higher amounts of other ingredients such as flour, and an estimation based on the curcumin content in the turmeric might be more acceptable. CONCLUSIONS: Thus, the amount of curcumin that can be obtained from the Korean diet in a day is 2.7-14.8 mg, corresponding to nearly one fourth of the daily curcumin intake in South Asia, although curcumin is rarely consumed in Korea.
Kwon, Youngjoo,Godwin, Andrew K. SAGE PUBLICATIONS 2017 REPRODUCTIVE SCIENCES Vol.24 No.4
<P>Binding of hepatocyte growth factor (HGF) to the c-MET receptor has mitogenic, motogenic, and morphogenic effects on cells. The versatile biological effects of HGF and c-MET interactions make them important contributors to the development of malignant tumors. We and others have demonstrated a therapeutic value in targeting the interaction of c-MET and HGF in epithelial ovarian cancer (EOC). However, both HGF and c-MET are expressed in the normal ovary as well. Therefore, it is important to understand the differences in mechanisms that control HGF signaling activation and its functional role in the normal ovary and EOC. In the normal ovary, HGF signaling may be under hormonal regulation. During ovulation, HGF-converting proteases are secreted and the subsequent activation of HGF signaling enhances the proliferation of ovarian surface epithelium in order to replenish the area damaged due to expulsion of the ovum. In contrast, EOC cells that exhibit epithelial characteristics constitutively express both c-MET and HGF-converting proteases such as urokinase-type plasminogen activator. In EOC, mechanisms to control the activation of HGF signaling are absent since HGF is provided locally from the tissue microenvironment as well as remotely throughout the body. Potential incessant HGF signaling in EOC may lead to an increase in proliferation, invasion through the stroma, and migration to other tissues of cancer cells. Therefore, targeting the interaction of c-MET and HGF would be beneficial in treating EOC.</P>