http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : KIMMINA (검색결과 37 건)
- 무료
- 기관 내 무료
- 유료
-
Cytokeratin expression profile in gastric carcinomas
Kim, Min A,Lee, Hye Seung,Yang, Han-Kwang,Kim, Woo Ho Elsevier 2004 Human pathology Vol.35 No.5
<P><B>Abstract</B></P><P>Cytokeratin (CK) is observed mainly in epithelial cells, and the diverse expression pattern of CK subtypes may be helpful in discriminating between primary and metastatic carcinomas in various organs, including the stomach. To clarify the CK expression profiles in gastric carcinomas, 329 consecutive specimens were immunohistochemically evaluated in terms of their CK subtypes using the tissue array method. The overall positive rates were 84.7% for CK4, 3.2% for CK5, 28.7% for CK6, 71.1% for CK7, 96.6% for CK8, 0% for CK10, 81.6% for CK13, 0.3% for CK14, 4.1% for CK16, 0% for CK17, 99.4% for CK18, 89.7% for CK19, and 30.0% for CK20. Well-differentiated or moderately differentiated carcinomas were related to several CKs, and mucinous carcinoma was associated with CK20 expression. Interestingly, CK7 and CK20 expression was associated with the mucin phenotype of gastric carcinoma, but this association had no diagnostic value. Epstein-Barr virus (EBV)—associated gastric carcinomas showed a tendency toward negative expression of CK7. CK6 expression was related to microsatellite instability (MSI), early pTNM stage, and better clinical outcome. In conclusion, CK expression profiles in consecutive gastric carcinomas demonstrate heterogeneity, and no single CK has diagnostic value by itself. CK expression is associated with various clinicopathologic parameters, mucin phenotype, EBV positivity, MSI status, and patient survival.</P>
-
Kim, Mi Na,Kim, Beom Kyung,Han, Kwang-Hyub Springer Japan 2013 Journal of gastroenterology Vol.48 No.6
<P>Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related mortality worldwide. Although hepatitis B still remains the most common risk factor worldwide, chronic hepatitis C virus (HCV) infection is the driving force for the increased incidence of HCC especially in Western countries and Japan. In hepatitis B virus (HBV)-endemic areas, after successful vaccination programs against HBV, chronic HCV infection is now emerging as an important cause of chronic liver diseases. Unlike patients with chronic hepatitis B, those with chronic hepatitis C (CHC) develop HCC in the presence of established cirrhosis in most cases. However, a significant minority of CHC develops HCC in the absence of cirrhosis. Although HCV is a RNA virus with little potential for integrating its genetic material into host genome, various HCV proteins, including core, envelope, and nonstructural proteins, have oncogenic properties by inducing oxidative stress, disturbing cellular regulatory pathways associated with proliferation and apoptosis, and suppressing host immune responses. Overall, a combination of virus-specific, host genetic, environmental, and immune-related factors are likely to determine progression to HCC. Strategies aimed at eliminating the virus may provide opportunities for effective prevention of the development of HCC. Pegylated interferon plus ribavirin therapy appears to be effective at reducing the risk of HCC in patients who achieve sustained virologic responses. In summary, with the emerging importance of CHC, mechanisms of HCV-associated hepatocellular carcinogenesis should be clarified to provide insight into advanced therapeutic and preventive approaches, which eventually decrease the incidence and mortality of HCC.</P>
-
Kim, Min-A,Lee, Hye-Seong Elsevier 2012 Food quality and preference Vol.25 No.2
<P><B>Highlights</B></P><P>► Roving experimental design using two different sample pairs allowed comparisons in <I>d</I>′ based on the same model. ► Duo-trio test using saltier-reference showed the higher test performance. ► Reference position in a test showed operational effects on the test performance. ► DTFM with constant-stronger-reference tended to show the highest test performance.</P> <P><B>Abstract</B></P><P>The effects of reference schemes (reference mode – constant vs. balanced-, number, position, and nature – stronger vs. weaker) on the performance of replicated duo-trio tests were investigated using four versions of duo-trio protocols (DTF, DTM, DTFR, and DTFM), using two different pairs of tomato juices with different sodium content. Examination of proportion of correct answers (Pc) and <I>d</I>′ estimates indicated that when the cognitive strategy was fixed to the comparison of distances (COD) strategy, the constant-reference mode showed the superior test performance over the balanced-reference mode, only for DTFM performed using the stronger reference. Among the tests with the balanced-reference mode, for DTF, estimates of <I>d′</I> of the tests using the stronger-reference (W-odd) were significantly higher than tests using the weaker-reference (S-odd), whereas the opposite was true for DTM, revealing the operational influence of the reference position. In general, the DTF or DTFM using the stronger (saltier) product as a constant-reference is recommended as an operationally more powerful protocol to discriminate products having high sodium contents.</P>
-
Monthly Variations in the Nutritional Composition of Antarctic Krill Euphausia superba
Kim, Min-A,Jung, Hae-Rim,Lee, Yang-Bong,Chun, Byung-Soo,Kim, Seon-Bong The Korean Society of Fisheries and Aquatic Scienc 2014 Fisheries and Aquatic Sciences Vol.17 No.4
The proximate composition and various specific components of Antarctic krill Euphausia superba, in the catch season between March and August were investigated. Frozen krill were freeze-dried and milled. The proximate composition comprised water, proteins, fats, ash, fatty acids, and amino acids, while the specific components were vitamins, minerals, nucleotides, betaine, and astaxanthin. The moisture content of the krill ranged from 77 to 80%, with the highest value in June, and the ash content was between 12 and 13%. The protein content was lowest in May, and the fat content was 18-19%, with the highest value in March. The amino acid content varied according to the season: taurine and glycine were highest in August; ${\beta}$-alanine was higher in April and May; and arginine, ornithine, and lysine were highest in March. The unsaturated fat content was ~50% and omega-3 fatty acids were highest in June. Oil-soluble vitamins A and E were highest in March, and the water-soluble vitamin content was less than that of oil-soluble vitamins. The mineral content was highest in June, and the most abundant mineral was sodium at 235.60 mg/100 g krill. The content of other minerals was lowest (2.94 mg/100 g) in April, except for lead. The nucleotide content was highest in July, while the betaine content was highest in April and lowest in June. The astaxanthin content was highest in May and ranged from 6 to 10 ppm in other months.
-
Kim, Min A,Jung, Eun Ji,Lee, Hye Seung,Lee, Hee Eun,Jeon, Yoon Kyung,Yang, Han-Kwang,Kim, Woo Ho Elsevier 2007 Human pathology Vol.38 No.9
<P><B>Summary</B></P><P><I>HER-2</I> gene amplification and the overexpression of HER-2 protein have been observed in various solid tumors, including gastric carcinomas. <I>HER-2</I> gene amplification has attracted research attention since the development of the new therapeutic agent trastuzumab. Here, we evaluated <I>HER-2</I> status in the surgically resected tissues of 248 gastric carcinoma cases using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and real-time quantitative polymerase chain reaction (q-PCR) and compared the results. In addition, we compared clinicopathologic characteristics with the presence of <I>HER-2</I> gene amplification and with protein overexpression. Among the 248 cases, 56 (22.6%) cases showed HER-2 overexpression (2+ or 3+) by IHC and 19 cases (7.7%) showed <I>HER-2</I> gene amplification by FISH. Four (2.1%) of the 192 cases negative (0 or 1+) by IHC showed amplification by FISH, whereas 15 (26.8%) of the 56 cases with HER-2 protein overexpression showed <I>HER-2</I> amplification by FISH. The correlation between IHC and FISH results was statistically significant (<I>P</I> < .001). HER-2 protein overexpression and <I>HER-2</I> gene amplification were common in cases with a well- or moderately differentiated histology according to the World Health Organization classification (<I>P</I> < .001) and in cases of intestinal type by the Lauren classification (<I>P</I> < .001). Real-time q-PCR results showed that calculated <I>HER-2</I>/<I>GAPDH</I> ratios were higher in amplified cases with 100.0% sensitivity and 96.9% specificity using FISH results as the standard. Measurements of <I>HER-2</I> expression by FISH and real-time q-PCR and of HER-2 protein by IHC were found to be highly concordant at determining HER-2 status in gastric carcinoma.</P>
-
Kim, Min A,Lee, Hye Seung,Lee, Hee Eun,Kim, Ji Hun,Yang, Han-Kwang,Kim, Woo Ho Blackwell Publishing Ltd 2009 Histopathology Vol.54 No.4
<P>Aims: </P><P>Epithelial–mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metastasis of various cancers. The aim was to evaluate the expression of EMT-related proteins in gastric carcinoma (GC).</P><P>Methods and results: </P><P>The expression of nine EMT-related proteins in the GC tissues of 598 patients was evaluated by immunohistochemistry using a tissue array method. In addition, clinicopathological characteristics and survival were compared with the expression of EMT-related proteins. Loss of epithelial protein and/or acquisition of the expression of mesenchymal proteins were observed in GC. These protein alterations were associated with diffuse type histology, advanced stage and poor patient outcome, respectively. Subjects were divided into three groups according to degree of EMT-related protein alteration. Increases in alteration of EMT-related protein were found to be significantly associated with poorly differentiated histology, higher pTNM stage and unfavourable outcome. Multivariate analysis showed that alterations in the expression of EMT-related proteins were independently associated with poor prognosis.</P><P>Conclusions: </P><P>Loss of epithelial proteins and/or the acquisition of mesenchymal proteins are associated with poorly differentiated histology, advanced stage and poor outcome in GC. The awareness and inhibition of EMT offer a promising target for prevention of metastatic progression and invasion.</P>
-
Kim, Mina,Park, Jae-Min,Um, Hyun-Ju,Lee, Dong-Hun,Lee, Kyu-Ho,Kobayashi, Fumihisa,Iwasaka, Yasunobu,Hong, Chun-Sang,Min, Jiho,Kim, Yang-Hoon WILEY-VCH Verlag 2010 Journal of basic microbiology Vol.50 No.3
<P>Candida rugosa lipase was immobilized on amino-functionalized magnetic supports via cross-linked enzyme aggregates (CLEA) and used to enhance the enzymatic degradation of polycaprolactone (PCL). The maximum amounts of lipase immobilized on the magnetic beads using glutaraldehyde as a coupling agent were determined to be 33.7 mg/g of beads with an 81% recovery of activity after immobilization. Compared to the free enzyme, the immobilized lipase showed the optimum pH at 1 unit higher (pH 8.0) and also retained its enzymatic activity at higher temperatures. There was 62.9% retention of lipase activity after 30 consecutive reuses, indicating its stability and reusability in aqueous media. Moreover, the immobilized lipase maintained more than 80% of its initial activity during 30 days storage period, while the free lipase lost all under same condition. In addition, the immobilized lipase showed a more than 6-fold increase in biodegradability over the free lipase when the immobilized lipase was used to degrade PCL in a batch system. Higher thermal and storage stability, as well as good durability after repeated use of the immobilized lipase CLEA, highlights its potential applicability as large scale continuous systems for the enzymatic degradation of PCL. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)</P>
-
Prevalence and Seroprevalence of High-Risk Human Papillomavirus Infection :
Kim, Min-A,Oh, Jin-Kyoung,Chay, Doo Byung,Park, Dong Choon,Kim, Seok Mo,Kang, Eun-Suk,Kim, Jae-Hoon,Cho, Chi-Heum,Shin, Hai-Rim,Seo, Kyung Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2010 Obstetrics and gynecology Vol.116 No.4
<P>OBJECTIVE:: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. METHODS:: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. RESULTS:: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. CONCLUSION:: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy. LEVEL OF EVIDENCE:: III.</P>
-
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
