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      • H3K27 methylation and H3S28 phosphorylation-dependent transcriptional regulation by INHAT subunit SET/TAF-Iβ

        Kim, J.Y.,Kim, K.B.,Son, H.J.,Chae, Y.C.,Oh, S.T.,Kim, D.W.,Pak, J.H.,Seo, S.B. North-Holland Pub ; Elsevier Science Ltd 2012 FEBS letters Vol.586 No.19

        Significant progress has been made in understanding the relationship between histone modifications and 'reader' molecules and their effects on transcriptional regulation. A previously identified INHAT complex subunit, SET/TAF-Iβ, binds to histones and inhibits histone acetylation. To investigate the binding specificities of SET/TAF-Iβ to various histone modifications, we employed modified histone tail peptide array analyses. SET/TAF-Iβ strongly recognized PRC2-mediated H3K27me½/3; however, the bindings were completely disrupted by H3S28 phosphorylation. We have demonstrated that SET/TAF-Iβ is sequentially recruited to the target gene promoter ATF3 after the PRC2 complex via H3K27me recognition and may offer additive effects in the repression of the target gene.

      • SCIESCOPUSKCI등재

        Effects of Egg Yolk Antibodies Produced in Response to Different Antigenic Fractions of E. coli O157:H7 on E. coli Suppression

        Chae, H.S.,Singh, N.K.,Ahn, C.N.,Yoo, Y.M.,Jeong, S.G.,Ham, J.S.,Kim, D.W. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11

        The objective of this research was to provide the characterization and method for producing anti-E. coli O157:H7 antibodies in egg-laying hens and to determine if the antibody can restrain the proliferation of E. coli O157:H7 in-vitro. Selected antigenic fractions (whole cell, outer membrane protein and lipopolysaccharide (LPS)) from E. coli O157:H7 were injected to hens in order to produce anti-E. coli O157:H7 antibodies. The immune response and the egg yolk antibodies of laying hens against the whole cell, outer membrane protein and LPS antigens were monitored by ELISA. The level of antibodies against whole cell antigen monitored through ELISA sharply increased after the initial immunization, and it was found to be maximum on day 49 however, the level was maintained up to day 70. Antibodies (5 mg/ml) directed against the whole cell inhibited E. coli proliferation 10-13 times more than outer membrane protein or LPS. The antibody response against the whole cell antigens appeared to have higher activity in restraining the proliferation of E. coli O157:H7 than antibody against outer membrane protein or LPS. Results reflected that increasing the IgY's in the egg yolk could prevent greater economic losses due to human and animal health from pathogenic bacteria i.e. E. coli O157:H7.

      • Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-ras<sup>LA1</sup> mice

        Chang, S-H,Kim, J-E,Lee, J-H,Minai-Tehrani, A,Han, K,Chae, C,Cho, Y-H,Yun, J-H,Park, K,Kim, Y-S,Cho, M-H Nature America, Inc. 2013 Cancer gene therapy Vol.20 No.6

        Conventional radiotherapy or chemotherapy for the long-term survival of patients with lung cancer is still difficult for treatment in metastatic and advanced tumors. Therefore, the safe and effective approaches to the treatment of lung cancer are needed. In this study, the effect of delivered eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) on lung cancer progression was evaluated. Recombinant adeno-associated virus (rAAV)-M3/4E-BP1 was delivered into 6-week-old K-ras<SUP>LA1</SUP> lung cancer model mice through a nose-only inhalation system twice a week for 4 weeks. Long-term repeated delivery of 4E-BP1 effectively reduced tumor progression in the lungs of K-ras<SUP>LA1</SUP> mice. Reduction of eIF4E by overexpression of 4E-BP1 resulted in suppression of cap-dependent protein expression of basic fibroblast growth factor (bFGF or FGF-2) and vascular endothelial growth factor (VEGF). In addition, delivered 4E-BP1 inhibited the proliferation of lung cancer cells in K-ras<SUP>LA1</SUP> mice model. Our results suggest that long-term repeated viral delivery of 4E-BP1 may provide a useful tool for designing lung cancer treatment.

      • Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures

        Kim, E-K,Seo, H-S,Chae, M-J,Jeon, I-S,Song, B-Y,Park, Y-J,Ahn, H M,Yun, C-O,Kang, C-Y Macmillan Publishers Limited 2014 Gene therapy Vol.21 No.1

        For successful clinical tumor immunotherapy outcomes, strong immune responses against tumor antigens must be generated. Cell-based vaccines compromise one strategy with which to induce appropriate strong immune responses. Previously, we established a natural killer T-cell (NKT) ligand-loaded, adenoviral vector-transduced B-cell-based anticancer cellular vaccine. To enhance tumor antigen delivery to B cells, we established a modified adenoviral vector (Ad-k35) that encoded a truncated form of the breast cancer antigen Her2/neu (Ad-k35HM) in which fiber structure was substituted with adenovirus serotype 35. We observed increased tumor antigen expression with Ad-k35HM in both human and murine B cells. In addition, an Ad-k35HM-transduced B-cell vaccine elicited strong antigen-specific cellular and humoral immune responses that were further enhanced with the additional loading of soluble NKT ligand KBC009. An Ad-k35HM-transduced, KBC009-loaded B-cell vaccine efficiently suppressed the in vivo growth of established tumors in a mouse model. Moreover, the vaccine elicited human leukocyte antigen (HLA)-A2 epitope-specific cytotoxic T-cell responses in B6.Cg (CB)-Tg (HLA-A/H2-D) 2Enge/Jat mice. These findings indicated that the Ad-k35 could be appropriate for the preclinical and clinical development of B-cell-based anticancer immunotherapies.

      • Si film electrodes with surface-modified Cu current collectors for micro Li batteries

        Lee, M.j.,Chae, M.r.,Jeong, J.s.,Noh, J.p.,Ahn, H.j.,Cho, K.k.,Choi, H.k.,Nam, T.h.,Kim, K.w.,Cho, G.b. Pergamon Press 2016 Materials research bulletin Vol.82 No.-

        <P>Si film electrodes were fabricated onsurface-modified Cu current collectors using an oxidation-reduction process. Flower-like nanostructures (FLNSs) with diameters of 2-3 mu m and plate-like nanostructures (PLNSs) with lengths of 1 m were formed on the Cu foil oxidized at 423 K for 0.5 h, but only the PLNSs remained after sonication. Reduction of the preoxidized Cu foil at 673 K resulted in the formation of platelike and coral -like nanostructures on the Cu foils reduced for 1 and 3 h and a smooth surface without specific structures on the Cu foil reduced for 6 h. The best electrochemical properties in terms of the first columbic efficiency (85.4%) and the cycle performance (67.3% at 50 cycles) were obtained from the Si film electrode fabricated on the Cu foil that had been reduced for 3 h because the coral -like nanostructures on the Cu foil enhanced the adhesion of the Si film and improved the structural stability of the Si film electrode during the electrochemical reactions. (C) 2016 Elsevier Ltd: All rights reserved.</P>

      • SCISCIESCOPUS

        Geochemical modeling of CO<sub>2</sub>-water-rock interactions for two different hydrochemical types of CO<sub>2</sub>-rich springs in Kangwon District, Korea

        Choi, B.Y.,Yun, S.T.,Kim, K.H.,Choi, H.S.,Chae, G.T.,Lee, P.K. Elsevier 2014 Journal of geochemical exploration Vol.144 No.1

        Naturally outflowing CO<SUB>2</SUB>-rich springs are a natural analogue of the seepage of sequestered CO<SUB>2</SUB> in geological storage sites. In Kangwon district of South Korea, two hydrochemically different types of CO<SUB>2</SUB>-rich springs (i.e., Ca-HCO<SUB>3</SUB>-type and Na-HCO<SUB>3</SUB>-type) occur together in a granitic terrain. Hydrochemical and water-isotope data (i.e., δ<SUP>18</SUP>O-δD and tritium) show that Na-HCO<SUB>3</SUB>-type springs have experienced significant silicate weathering processes over a long residence time at depths, while Ca-HCO<SUB>3</SUB>-type springs were formed by the mixing of Na-HCO<SUB>3</SUB>-type springs with shallow groundwater during ascent. In this study, diverse geochemical models including mixing, ion exchange and reaction path were investigated to verify the geochemical processes accounting for the occurrence of two contrasting types of CO<SUB>2</SUB>-rich springs. The mixing and ion exchange models reveal that Ca-HCO<SUB>3</SUB>-type springs are well explained by reverse cation exchange occurring during the mixing of Na-HCO<SUB>3</SUB>-type springs with shallow groundwater. The Na-HCO<SUB>3</SUB>-type springs are well explained by the reaction path modeling including the dissolution of silicate minerals (plagioclase, K-feldspar and biotite) and the precipitation of secondary minerals (calcite, kaolinite, muscovite and Mg-beidellite), implying that dissolved carbon is sequestered by calcite precipitation (i.e., mineral trapping). However, the concentrations of K in our modeling results are far below those of K observed in Na-HCO<SUB>3</SUB>-type springs, because of the precipitation of muscovite considered in the model, suggesting the partial disequilibrium state of the aquifer during the hydrolysis of K-feldspar under high P<SUB>CO'2</SUB> conditions. This result implies that to better predict long-term CO<SUB>2</SUB>-water-rock interactions in a geological storage site with abundant K-feldspar, the secondary K-bearing minerals should be carefully predicted, because a target aquifer can be far from chemical equilibrium during the storage period. This study shows that geochemical modeling can be effectively used to predict the hydrochemical changes of groundwater during long-term CO<SUB>2</SUB>-water-rock interactions and subsequent leakage toward surface in K-feldspar rich aquifer, although it should be included in a fully coupled computational approach between fluid flow, heat transfer and reactive mass transport processes in the future research.

      • KCI등재

        X-ray Absorption and Emission Spectroscopic Studies of BiMn2-xTixO5 (0 ≤ x ≤ 0:5)

        K. H. Chae,P. Thakur,황정남,G. S. Chang,D. K. Shukla,S. Mollah,Ravi Kumar 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.3

        The electronic structure of the multiferroic BiMn2-xTixO5(0 ≤ x ≤ 0:5) system was studied by using X-ray absorption spectroscopy (XAS) and X-ray emission spectroscopy (XES). The polycrystalline bulk BiMn2-xTixO5 samples were synthesized using a conventional solid-state reaction technique. XAS and XES spectroscopic studies on the O K-, Mn K-, L3;2- and Ti L3;2-edges of the BiMn2-xTixO5 samples and of the reference compounds were performed and the results were compared in order to determine the exact chemical states of functioning ions. The O K-edge XAS and XES results demonstrate a competition between the Mn 3d and the Ti 3d orbitals on hybridizations with the O 2p orbital. The Mn K- and Mn L3;2-edge XAS spectra suggest that the Mn3+ /Mn4+ ratio increases with increasing Ti doping and drives the system towards octahedral symmetry. On the other hand, Ti ions remain at 4+ states for all compositions, as shown by the Ti L-edge XAS. Here, we present and discuss the detailed electronic structures of the BiMn2-xTixO5 samples.

      • KCI등재후보

        纖維用亞麻의 育種에 關한 硏究 (1) 量的形質의 遺傳力과 그들間의 相關

        K.Y. Chung(鄭奎鎔),E.S. Lee(李殷燮),K.H. Kang(姜光熙),Y.A. Chae(蔡永岩) 한국육종학회 1970 한국육종학회지 Vol.2 No.1

        畓前作 纖維用 亞麻育種의 當面課題인 長莖 早熟品種을 育成하기 위하여 4交配組合의 F₂에서 우선 몇가지 形質에 對한 廣義의 遺傳力을 調査하였던바 얻어진 結果는 다음과 같다. 1. 草長에 對한 遣傳力은 4個組合이 서로 비슷하게 높았으며 이들의 全體平均은 0.745였다. 2. 莖長의 遺傳力은 組合에 따라 變異가 컸으며 Wiera×Horal는 0.73으로 높은 反面에 Fibura×Horal는 0.29로 甚히 낮았고 이들 4組合의 平均은 0.495였다. 3. 開花日數의 遺傳力도 組合間 差異가 커서 Wiera×Horal, Fibura×Horal는 各各 0.76, 0.78로 높은 反面에 Atlas×Fibura는 0.26으로서 가장 낮았으며 이들 4組合의 平均은 0.578이었다. 4. 分離世代인 4個組合의 F₂에서 이들 形質間의 相關은 草長對 莖長은 높은 正相關(0.7016), 草長對開花日數, 莖長對開花日數間에는 各各 0.4562, 0.5812로 比較的 높은 正相關關係를 보았다. 5. 遺傳力과 遺傳進展量으로 볼때 草長과 莖長이 높은 方向으로 選拔은 可能하나 早熟이면서 同時에 草業과 莖長이 높은 個體의 選拔은 熟期와 草長間에 높은 正相關 때문에 難點이 있다고 본다. In order to develop an efficient breeding program of flax for long fiber of high quality and early maturity, informations are needed on heritability of plant height, stem length, flowering date and on associations among these characters. Four crosses were made; Wiera×Horal, Atlas×Horal, Fibura×Horal and Atlas×Fibura. Data were taken on individual plant basis for the population and their parents. Estimation of heritability was obtained by: (수식), where VF₂is total F₂variance of the character, VP₁and VP₂are environmental variances of the respective parents. (1) Heritability of plant height for the four combinations was high with almost same values and their total average was 0.745. (2) Variation of heritability of stem length in the four combinations was some what large and their average was 0.495. (3) Average of heritability of flowering date for the four combinations was 0.578 and the Atlas×Fibura combination showed the lowest heritability (H=0.26). (4) In the segregating F₂population, plant height was positively correlated with stem length(r=0.7016**) and flowering date(r=0.4562**) and stem length showed positive correlation with flowering date (r=0.5812**). (5) Selection on plant height or stern length is possible based on the high heritability of these characters but the high positive correlation between plant height and heading date indicates the difficulty of the selection of tall height plant with early maturity.

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