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      • SCOPUSKCI등재

        Thermal Evolution of BaO-CuO Flux as Sintering Aid for Proton Conducting Ceramic Fuel Cells

        Biswas, Mridula,Hong, Jongsup,Kim, Hyoungchul,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Lee, Hae-Weon,Yoon, Kyung Joong The Korean Ceramic Society 2016 한국세라믹학회지 Vol.53 No.5

        The eutectic melt of BaO-CuO flux is known to be a potential sintering aid for $Ba(Zr,Y)O_3$ (BZY) electrolyte for proton-conducting ceramic fuel cells (PCFCs). A density of BZY higher than 97% of theoretical density can be achieved via sintering at $1300^{\circ}C$ for 2 h using a flux composed of 28 mol% BaO and 72 mol% CuO. In the present study, chemical and structural evolution of BaO-CuO flux throughout the sintering process was investigated. An intermediate holding step at $1100^{\circ}C$ leads to formation of various impurity compounds such as $BaCuO_{1.977}$, $Ba_{0.92}Cu_{1.06}O_{2.28}$ and $Cu_{16}O_{14.15}$, which exhibit significantly larger unit cell volumes than the matrix. The presence of such secondary compounds with large lattice mismatch can potentially lead to mechanical failure. On the other hand, direct heating to the final sintering temperature produced CuO and $Cu_2O$ as secondary phases, whose unit cell volumes are close to that of the matrix. Therefore, the final composition of the flux is strongly affected by the thermal history, and a proper sintering schedule should be used to obtain the desired properties of the final product.

      • Graphene vs Carbon Nanotubes in Electronic Devices: Graphene Versus Carbon Nanotubes in Electronic Devices (Adv. Funct. Mater. 20/2011)

        Biswas, Chandan,Lee, Young Hee WILEY‐VCH Verlag 2011 Advanced Functional Materials Vol.21 No.20

        <P>Graphene and CNT exhibit excellent electronic and optoelectronic properties. In a Feature Article on page 3806, Young Hee Lee and Chandan Biswas review recent progress in carbon nanotube and graphene research. The review compares the electronic and opto‐electronic properties of carbon nanotubes and graphene, and their performances in devices such as transparent conducting films (transparency and sheet resistance) and field‐effect transistors (device types, ambipolarity, mobility, doping strategy, FET‐performance, logic and memory operations). </P>

      • SCIESCOPUSKCI등재

        Effect of Enrobing and Adding Antioxidants on the Quality of Pork Patties

        Biswas, A.K.,Keshri, R.C.,Kumar, Sunil Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.9

        The effect of applying edible coating and addition of antioxidants (butylated hydroxyanisole (BHA) plus butylated hydroxytoluene (BHT) in a 1:1 ratio) on pork patties were investigated prior to achieve desired physico-chemical, microbiological and sensory qualities. For this, five treatments were conducted as (i) control (neither coated nor antioxidants treated); (ii) coated without antioxidants treated; (iii) coated and antioxidants added in the batter mix only (100 ppm); (iv) coated and antioxidants added in meat mix (100 ppm) only; and (v) coated and antioxidants added both in the batter mix (50 ppm) and the meat mix (50 ppm). Addition of antioxidants both in the batter mix and the meat mix significantly (p<0.05) reduced the microbial loads and thiobarbituric acid (TBA) values. The TBA values significantly (p<0.05) increased up to day 14 and then progressively increased with the advancement of each interval of storage days up to 28 days. Total plate count significantly (p<0.05) increased with the increase in storage days.Coliform and Staphylococcus aureus were absent throughout the storage days in all samples. Staphylococcus aureus however, were present in the control group at day 14 and in enrobed (coated) patties (without antioxidants treated) at 28th day. Addition of antioxidants to batter mix and meat mix did not substantially enhance bacteriostatic activity. Application of coatings and antioxidants retarded the loss of firmness, flavor, changes in appearance and color, and also other sensory attributes. Control patties were better with respect to microbial quality and TBA values but had poorer sensory quality than coated patties.

      • SCIESCOPUSKCI등재

        Growth Hormone Gene Polymorphism and Its Effect on Birth Weight in Cattle and Buffalo

        Biswas, T.K.,Bhattacharya, T.K.,Narayan, A.D.,Badola, S.,Kumar, Pushpendra,Sharma, Arjava Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.4

        The study was carried out in Sahiwal, Holstein Friesian, Jersey and crossbred cattle and Murrah, Bhadwari, Jaffarabadi, Nagpuri and Surti buffaloes maintained at different organized herds to work out the polymorphism at growth hormone locus and study its effect on birth weight. A 223 bp fragment of the gene was amplified and digested with Alu I restriction enzyme. Two alleles, L and V with three genotypes LL, LV and VV were observed in Jersey, Holstein and cross bred cattle. Sahiwal cattle and buffalo were monomorphic for this locus producing only one genotype LL and one allele L. The frequency of L allele was comparatively higher in Holstein and crossbred cattle while in Jersey breed, the frequency of this allele was intermediate. The effect of genotype on birth weight was significant and LV genotype had higher birth weight than other genotypes. Hence, LV genotype in Holstein Friesian favored higher birth weight.

      • KCI등재후보

        Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19

        Biswas, Subrata K.,Mudi, Sonchita R. Korea Genome Organization 2020 Genomics & informatics Vol.18 No.4

        The severity of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly varies from patient to patient. In the present study, we explored and compared mutation profiles of SARS-CoV-2 isolated from mildly affected and severely affected COVID-19 patients in order to explore any relationship between mutation profile and disease severity. Genomic sequences of SARS-CoV-2 were downloaded from Global Initiative on Sharing Avian Influenza Data (GISAID) database. With the help of Genome Detective Coronavirus Typing Tool, genomic sequences were aligned with the Wuhan seafood market pneumonia virus reference sequence and all the mutations were identified. Distribution of mutant variants was then compared between mildly and severely affected groups. Among the numerous mutations detected, 14408C>T and 23403A>G mutations resulting in RNA-dependent RNA polymerase (RdRp) P323L and spike protein D614G mutations, respectively, were found predominantly in severely affected group (>82%) compared with mildly affected group (<46%, p < 0.001). The 241C>T mutation in the non-coding region of the genome was also found predominantly in severely affected group (p < 0.001). The 3037C>T, a silent mutation, also appeared in relatively high frequency in severely affected group compared with mildly affected group, but the difference was not statistically significant (p = 0.06). We concluded that spike protein D614G and RdRp P323L mutations in SARS-CoV-2 are associated with severity of COVID-19. Further studies will be required to explore whether these mutations have any impact on the severity of disease.

      • Thermal Stability of Phaseolus vulgaris Leucoagglutinin: a Differential Scanning Calorimetry Study

        Biswas, Shyamasri,Kayastha, Arvind M. Korean Society for Biochemistry and Molecular Biol 2002 Journal of biochemistry and molecular biology Vol.35 No.5

        Phaseolus vulgaris phytohemagglutinin L is a homotetrameric-leucoagglutinating seed lectin. Its three-dimensional structure shows similarity with other members of the legume lectin family. The tetrameric form of this lectin is pH dependent. Gel filtration results showed that the protein exists in its dimeric state at pH 2.5 and as a tetramer at pH 7.2. Contrary to earlier reports on legume lectins that possess canonical dimers, thermal denaturation studies show that the refolding of phytohemagglutinin L at neutral pH is irreversible. Differential scanning calorimetry (DSC) was used to study the denaturation of this lectin as a function of pH that ranged from 2.0 to 3.0. The lectin was found to be extremely thermostable with a transition temperature around $82^{\circ}C$ and above $100^{\circ}C$ at pH 2.5 and 7.2, respectively. The ratio of calorimetric to vant Hoff enthalpy could not be calculated because of its irreversible-folding behavior. However, from the DSC data, it was discovered that the protein remains in its compact-folded state, even at pH 2.3, with the onset of denaturation occurring at $60^{\circ}C$.

      • The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.

        Biswas, D K,Dai, S C,Cruz, A,Weiser, B,Graner, E,Pardee, A B National Academy of Sciences 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.98 No.18

        <P>The effect of a kinase inhibitor Go6796 on growth of epidermal growth factor (EGF)-stimulated estrogen receptor negative (ER-) breast cancer cells in vivo and role of nuclear factor kappa B (NF-kappaB) on tumorogenesis have been investigated. This was studied in an animal model by implanting ER- mouse mammary epithelial tumor cells (CSMLO) in syngeneic A-J mice. (i) Local administration of Go6976 an inhibitor of protein kinases C alpha and beta inhibited growth of tumors and caused extensive necrotic degeneration and regression of the tumors without causing any microscopically detectable damage to the vital organs liver and lung. (ii) Stable expression of dominant-negative mutants of the beta subunit (dnIkkbeta) of the inhibitory kappa B (IkappaB) kinase (dnIkk) that selectively blocked activation of NF-kappaB caused loss of tumorigenic potential of CSMLO cells. Stable expression of dnIkkbeta also blocked phorbol 12-myristate 13-acetate (PMA)-induced activation of NF-kappaB and overexpression of cyclin D1, concomitantly with the loss or reduced tumorigenic potential of these cells. Thus, results from in vivo and in vitro experiments strongly suggest the involvement of NF-kappaB in ER- mammary epithelial cell-mediated tumorigenesis. We propose that blocking NF-kappaB activation not only inhibits cell proliferation, but also antagonizes the antiapoptotic role of this transcription factor in ER- breast cancer cells. Thus, NF-kappaB is a potential target for therapy of EGFR family receptor-overexpressing ER- breast cancers.</P>

      • SCIESCOPUSKCI등재

        The effect on deflection of steel diaphragm of pressure sensor due to change in boundary condition in the welded region

        Biswas, P. V.,Kim, H. Y.,Ahn, J. H. Springer Science + Business Media 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4

        <P>Manufacturing a high-pressure sensitive diaphragm type sensor is a complex task. Due to it's complex shape, several parts are designed individually. It involves welding of several parts. As welding involves several parameters it's difficult to control the welding geometry where it is being fused. So it is likely that the physical boundary condition of the welded region will be different from the theoretical boundary conditions. So the change in boundary condition will make the deflection of the diaphragm different. For a precision device, any effect of a change in boundary condition can affect the deflection of the diaphragm largely. Thus, any effect of imperfect welding in a high precision measuring device can hamper the sensitivity of the particular device. A welded diaphragm of steel for a pressure sensor using eddy current sensor to detect it's deflection due to pressure can lose it's effectivity, due to the unpredictable boundary conditions created after the welding. In this paper, we will be trying to find the cause of deviation between the theoretical and experimental results due to the effect of a change in boundary conditions at the welded region.</P>

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