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고분해능질량분석기 기반의 표적, 추정, 비표적 분석기법을 활용한 수환경 미량오염물질 및 환경변환체 탐색: A review
전준호 ( Junho Jeon ),박나리 ( Naree Park ),이선홍 ( Sun-hong Lee ) 한국환경분석학회 2016 환경분석과 독성보건 Vol.19 No.4
Micropollutants including pharmaceuticals, personal care products, pesticides, etc., and their transformation products (TP) are widely distributed in environmental media. However, limited information on their occurrence and concentration is available, at least partially due to lack of precise, reliable analytical tools. Recently, highly advanced instrument such as high resolution mass spectrometry (HRMS) has been commercially available and applicable for the detection of micropollutants and TPs. In addition, HRMS relevant screening techniques, suspect and nontarget screening, have been developed and optimized to identify unpredictable and unknown pollutants at trace levels. In this review paper, prior micropollutants and their TPs are suggested via literature survey, and the procedure of target/suspect/nontarget screening for their identification are introduced in detail with technical steps. Finally, the applicability of HRMS-based identification methods is discussed with lessons from previous studies. Considering the accuracy and applicability, suspect/nontarget screening approaches with HRMS are expected to extend our knowledge on micropollutants and TPs under the cover.
The study on biotransformation of organophosphate flame retardants in aquatic ecosystem
Yeowool Choi(최여울),Junho Jeon(전준호),Sang Don Kim(김상돈) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Biotransformation is an important mechanism in predicting the transformed structure and toxicity of organic pollutants in aquatic ecosystems. The effects of triphenyl phosphate (TPHP), an organophosphate flame retardant, were investigated in the study. TPHP has been widely used in manufacturing, and it is especially toxic to aquatic organisms. When TPHP was exposed to the aquatic environment, biotransformation products were identified according to the species of the aquatic food web (producer-consumer-decomposer). Liquid chromatography-high resolution mass spectrometry was used for chemical analysis. And the toxicity of biotransformation products was predicted the toxicity using the ecological structure-activity relationship model. As a result, 29 biotransformation products of TPHP were identified in aquatic species (green algae, daphnid, fish, and microorganisms). Most of the biotransformation products were predicted to be less toxic than the parent compound, TPHP. But some biotransformation products, Hydroquinone, beta-lyase compound, and fatty acid combined products, were showed to be high toxicity.
LC-HRMS를 이용한 송사리 내 의약품 농축 및 생체변환 연구
차현전 ( Hyeonjeon Cha ),전준호 ( Junho Jeon ) 한국환경분석학회 2021 환경분석과 독성보건 Vol.24 No.2
Theoccurrenceofpharmaceuticalsintheaquaticenvironmenthasbeenincreasingsteadilyowingtotheincreasinguseofpharmaceuticalsinourdailylife.Thisresultsinincreasingchallengesofenvironmentalhealthriskaspharmaceuticalsinthesurfacewatercanbeaccumulatedandtransformedinaquaticorganisms.ThepurposeofthisstudywastopredictthebioconcentrationandbiotransformationofseveralpharmaceuticalsinJapanesemedaka(Oryziaslatipes)usinga96hexposuretest.BasedonaninvestigationofthemostfrequentlydetectedpharmaceuticalsinthesurfacewatersinSouthKorea,11targetcompoundswereselectedincludingatenolol,caffeine,carbamazepine,diclofenac,fluoxetine,irbesartan,losartan,mefenamicacid,metoprolol,naproxen,andvenlafaxine.Abioconcentrationfactorof1.9,31.3,and10.7wasexpectedinfishowingtotheaccumulationofcarbamazepine,fluoxetine,andmefenamicacid,respectively.Atotalof12biotransformationproducts(BTPs)weretentativelyidentifiedviaoxidation,hydroxylation,dealkylation,anddemethylationreactions.Insummary,itisexpectedthattheseBTPsrepresentedbymolecularstructuresderivedfromtheirparentcompoundscanbeutilizedtoevaluatethechangeintoxicityofBTPscomparedtothatoftheparentcompounds.