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한석호(Suk-Ho Han),서홍석(Hong-Seok Seo),염정완(Jung-Won Youm) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.1
본 논문은 국산 배와 일본산 배에 대한 국내소비자의 무차별 선호를 가정한 가격격차 방법론을 적용하여 일본산 배의 수입금지 조치 해제 시 경제적 · 정량적 영향을 사전에 분석하는 방법론을 소개한다. 방법론을 이용하여 2018년 일본산 배의 수입허용 가정 시 시뮬레이션을 수행한 결과, 연평균 5만 톤의 일본산 배가 국내시장에 유입될 것으로 추정된다. 이 수입량은 국내 배 가격하락 뿐만 아니라 국산 배 생산량 감소를 야기하여 국내 배 생산 감소효과를 초래하여, 연평균 930억원 수준의 직접적인 피해가 예상된다. 국내 배 재배면적과 생산량은 베이스라인 대비 0.7%, 1.4% 감소할 것으로 예측된다. 또한, 생산 · 소비 대체재를 포함한 다른 품목 부문에 미치는 간접적인 영향을 합한 전체 농업분야의 연평균 감소액은 약 2,090억 원 수준으로 베이스라인 대비 0.4% 감소할 것으로 전망된다. 본 연구에서 제안한 SPS 수입금지 조치 해제 시나리오 영향평가는 기존에 수행해오던 양허안 중심의 시나리오 분석과 병행하여, 메가 FTA 참여 시 농업분야 파급영향의 사전분석 방법론을 개선할 것으로 기대된다. This paper proposed a methodology to analyze the economic and quantitative effects of lifting the import ban on Japanese pears by applying a price gap approach in the absence of any preference for either type of pear. Assuming that Korea will allow Japanese pear imports in 2018, the simulation results show that an annual average of 50,000 tons will flow into the domestic market from Japan. These imports will cause a decrease in the price and production of domestic pears, which would have a direct effect on the domestic pear industry, leading to an annual average reduction of 93 billion won. The cultivation area and production quantity are projected to be decreased by 0.7% and 1.4%, respectively, compared to the baseline. Also, the annual average reduction in the overall agriculture sector is predicted to be about 209 billion won, which is a 0.4% reduction compared to the baseline. This research is expected to improve the methodologies available for proactive analysis, with the existing analysis focused on customs tariffs when Korea considers joining mega-FTAs.
Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer’s disease mouse model
Youm, Jung Won,Kim, Hee,Han, Jee Hye Lo,Jang, Chang Hwan,Ha, Hee Jin,Mook-Jung, Inhee,Jeon, Jae Heung,Choi, Cheol Yong,Kim, Young Ho,Kim, Hyun Soon,Joung, Hyouk Elsevier 2005 FEBS letters Vol.579 No.30
<P><B>Abstract</B></P><P>Beta amyloid (Aβ) is believed one of the major pathogens of Alzheimer’s disease (AD), and the reduction of Aβ is considered a primary therapeutic target. Immunization with Aβ can reduce Aβ burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Aβ1–42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Aβ burden in the brain. Thus, Aβ tandem repeats can be expressed in transgenic potato plants to form immunologically functional Aβ, and these potatoes has a potential to be used for the prevention and treatment of AD.</P>
Youm, Jung Won,Won, Young Suk,Jeon, Jae Heung,Moon, Ki Beom,Kim, Hyoung Chin,Shin, Kee-Sun,Joung, Hyouk,Kim, Hyun Soon American Society for Microbiology 2010 Clinical and vaccine immunology Vol.17 No.12
<B>ABSTRACT</B><P>The ability of potato-derived major surface antigen of hepatitis B virus (P-HBsAg) to elicit antibody responses to different dosages of P-HBsAg ranging from 0.02 to 30 μg administered orally in mice was examined. All immunized groups produced specific serum IgG and fecal IgA antibodies against P-HBsAg, even at low levels (<5 μg), after administration of a 0.5-μg yeast-derived HBsAg (Y-HBsAg; LG Life Sciences, Republic of Korea) booster.</P>
Economic impact of digitalization on agriculture: a Korean perspective
Jung-Won Youm,명수환,유정호 충남대학교 농업과학연구소 2022 Korean Journal of Agricultural Science Vol.49 No.1
The global trade environment is rapidly changing. The spread of COVID-19 promotes digitalization, and online transactions are becoming the new normal. Currently, Korea is actively introducing information and communication technology (ICT) that uses the internet of things (IoT) in relation to agriculture. However, few studies have analyzed the impact of digitalization on trade in the agricultural sector. Thus, the purpose of this study is to examine how the introduction of digital technology can affect the economy and trade of Korea. In this study, we estimate the impact of introducing digital technologies using the computable general equilibrium (CGE) model. The results of this analysis indicate that the GDP could increase by 3.82% to 10.53%. Also, agricultural production and trade according to the model will significantly increase to 8.67% and 5.72%, respectively, through a productivity increase from Blockchain, IoT, and artificial intelligence (AI) technologies, despite logistics inefficiencies. Although the effects of digitalization could be significant, farmers are still struggling to introduce digital technologies, stemming from the fact that government support systems are concentrated in only a few sub-sectors. In this regard, support in this area must be expanded and diversified according to the current environment of agriculture in Korea.
Youm, Hye Won,Lee, Jung Ryeol,Lee, Jaewang,Jee, Byung Chul,Suh, Chang Suk,Kim, Seok Hyun Oxford University Press 2014 Human reproduction Vol.29 No.4
<P><B>STUDY QUESTION</B></P><P>What is the optimal vitrification protocol according to the cryoprotective agent (CPA) for ovarian tissue (OT) cryopreservation?</P><P><B>SUMMARY ANSWER</B></P><P>The two-step protocol with 7.5% ethylene glycol (EG) and 7.5% dimethyl sulfoxide (DMSO) for 10 min then 20% EG, 20% DMSO and 0.5 M sucrose for 5 min showed the best results in mouse OT vitrification.</P><P><B>WHAT IS KNOWN ALREADY</B></P><P>Establishing the optimal cryopreservation protocol is one of the most important steps to improve OT survival. However, only a few studies have compared vitrification protocols with different CPAs and investigated the effect of <I>in vitro</I> culture (IVC) on vitrified–warmed OT survival. Some recent papers proposed that a combination of CPAs has less toxicity than one type of CPA. However, the efficacy of different types and concentrations of CPA are not yet well documented.</P><P><B>STUDY DESIGN, SIZE, DURATION</B></P><P>A total of 644 ovaries were collected from 4-week-old BDF1 mice, of which 571 ovaries were randomly assigned to 8 groups and vitrified using different protocols according to CPA composition and the remaining 73 ovaries were used as controls. After warming, each of the eight groups of ovaries was further randomly divided into four subgroups and <I>in vitro</I> cultured for 0, 0.5, 2 and 4 h, respectively. Ovaries of the best two groups among the eight groups were autotransplanted after IVC.</P><P><B>PARTICIPANTS/MATERIALS, SETTING, METHODS</B></P><P>The CPA solutions for the eight groups were composed of EDS, ES, ED, EPS, EF, EFS, E and EP, respectively (E, EG; D, DMSO; P, propanediol; S, sucrose; F, Ficoll). The IVC medium was composed of α-minimal essential medium, 10% fetal bovine serum and 10 mIU/ml follicle-stimulating hormone (FSH). Autotransplantation of vitrified–warmed OTs after IVC (0 to 4 h) using the EDS or ES protocol was performed, and the grafts were recovered after 3 weeks. Ovarian follicles were assessed for morphology, apoptosis, proliferation and FSH level.</P><P><B>MAIN RESULTS AND THE ROLE OF CHANCE</B></P><P>The percentages of the morphologically intact (G1) and apoptotic follicles in each group at 0, 0.5, 2 and 4 h of IVC were compared. For G1 follicles at 0 and 4 h of IVC, the EDS group showed the best results at 63.8 and 46.6%, respectively, whereas the EP group showed the worst results at 42.2 and 12.8%, respectively. The apoptotic follicle ratio was lowest in the EDS group at 0 h (8.1%) and 0.5 h (12.7%) of IVC. All of the eight groups showed significant decreases in G1 follicles and increases in apoptotic follicles as IVC duration progressed. After autotransplantation, the EDS 0 h group showed a significantly higher G1 percentage (84.9%) than did the other groups (42.4–58.8%), while only the ES 4 h group showed a significant decrease in the number of proliferative cells (80.6%, 87.6–92.9%). However, no significant differences in apoptotic rates and FSH levels were observed between the groups after autotransplantation.</P><P><B>LIMITATIONS, REASONS FOR CAUTION</B></P><P>The limitation of this study was the absence of <I>in vitro</I> fertilization using oocytes obtained from OT grafts, which should be performed to confirm the outcomes of ovarian cryopreservation and transplantation.</P><P><B>WIDER IMPLICATIONS OF THE FINDINGS</B></P><P>We compared eight vitrification protocols according to CPA composition and found the EDS protocol to be the optimal method among them. The data presented herein will help improve OT cryopreservation protocols for humans or other animals.</P><P><B>STUDY FUNDING/COMPETING INTEREST(S)</B></P><P>This study was supported by a grant (No. A120080) from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea.</P>