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Expression of protein S100A4 is a predictor of recurrence in colorectal cancer.
Kwak, Jung-Myun,Lee, Hyun-Joo,Kim, Seon-Hahn,Kim, Han-Kyeom,Mok, Young-Jae,Park, Young-Tae,Choi, Jong-Sang,Moon, Hong-Young WJG Press 2010 WORLD JOURNAL OF GASTROENTEROLOGY Vol.16 No.31
<P>To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53.</P>
Jung, Jeeyoun,Jung, Youngae,Bang, Eun Jung,Cho, Sung-il,Jang, You-Jin,Kwak, Jung-Myun,Ryu, Do Hyun,Park, Sungsoo,Hwang, Geum-Sook Raven Press 2014 Annals of Surgical Oncology Vol.21 No.suppl4
<P>Mass screening for gastric cancer (GC), particularly using endoscopy, may not be the most practical approach as a result of its high cost, lack of acceptance, and poor availability. Thus, novel markers that can be used in cost-effective diagnosis and noninvasive screening for GC are needed.</P>
Regional Difference in Colonic Motility Response to Electrical Field Stimulation in Guinea Pig
( Jung Myun Kwak ),( Reji Babygirija ),( Irena Gribovskaja Rupp ),( Toku Takahashi ),( Shigeru Yamato ),( Kirk Ludwig ) 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
Background/Aims In isolated guinea-pig colon, we investigated regional differences in peristalsis evoked by intrinsic electrical nerve stimulation. Methods Four colonic segments from mid and distal colon of Hartley guinea pigs, were mounted horizontally in an organ bath. Measurement of pellet propulsion time, intraluminal pressure, electrical field stimulation (EFS; 0.5 ms, 60 V, 10 Hz), and response of pharmacological antagonists, were performed to isolated segments of colon to determine the mechanisms underlying peristaltic reflexes evoked by focal electrical nerve stimuli. Results In fecal pellet propulsion study, the velocity of pellet propulsion was significantly faster in the distal colon and decreased gradually to the proximal part of the mid colon. Intraluminal pressure recording studies showed that luminal infusion initiated normal peristaltic contractions (PCs) in 82% trials of the distal colon, compared to that of mid colon. In response to EFS, the incidence of PCs was significantly increased in the distal colon in contrast, the incidence of non-peristaltic contractions (NPCs) was significantly higher in the middle-mid colon, distal-mid colon and distal colon, compared to that of proximal-mid colon. Addition of L-NAME into the bath increased the frequency of NPCs. EFS failed to cause any PCs or NPCs contractions in the presence of hexamethonium, atropine or tetrodotoxin. Conclusions This study has revealed that electrical nerve stimulation of distal colon is the most likely region to elicit a peristaltic wave, com - pared with the mid or proximal colon. Our findings suggest that EFS-evoked PCs can be modulated by endogenous nitric oxide.
지속적 외래 복막 투석을 위한 도관 삽입술 및 도관 관련 합병증에 대한 연구
곽정면(Jung Myun Kwak),정석인(Suk In Jung),민연기(Youn Ki Min),강석형(Seok Hyung Kang),조용걸(Yong Geul Joh),조민영(Min Young Cho),송태진(Tae Jin Song),이재복(Jae Bok Lee),배정원(Jeoung Won Bae),서성옥(Sung Ok Suh),김영철(Young Chul 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.62 No.2
Jeong-Min Choo,Se-Jin Baek,Jung-Myun Kwak,Jin Kim,Seon-Hahn Kim 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.1
Purpose: Clinically suspected T4 stage colon cancer from a preoperative exam is often diagnosed as T3 stage colon cancer pathologically after surgery, raising concerns about understaging. The aims of this study were to compare the survival of clinical T3 and T4 colon cancer patients who had received a pathologic T3 stage diagnosis postoperatively. Methods: Patients who were diagnosed with pathologic T3 stage colon cancer postoperatively were reviewed. Patients with clinically suspected T3 or T4 stage cancer on preoperative exam were enrolled in the study. We compared patient demographics and survival of the cT3 and cT4 groups. Results: Out of the 536 patients with pT3 colon cancer, 503 patients were cT3 (93.8%) and 33 patients were cT4 (6.2%) preoperatively. The most common reason for suspected clinical T4 stage cancer was free perforation (78.8%). There were no statistically significant differences between the 5-year overall survival and the total 5-year disease-free survival (DFS) between the cT3 and cT4 groups; however, local recurrence was significantly higher in the cT4 group (local 5-year DFS: 98.6% vs. 84.0%, P < 0.001). Multivariate analysis showed cT stage was associated with local recurrence, but the association was not statistically significant (P = 0.056). Conclusion: Preoperative clinically suspected T4 stage colon cancer showed inferior local recurrence despite a postoperative pathologic diagnosis of T3 stage cancer. It is necessary to address the shortcomings of pathologic exams in the matter of the understaging of T4 colon cancer, and to reinforce the treatment for local control in patients with cT4 colon cancer.