한국인에서 혈소판 당단백 Ⅱb/Ⅲa 유전자 다형성과 관동맥 성형술 후 재 협착과의 관계

이민수,이정우,김보영,임대승,강정아,김정희,김윤철,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Platelet aggregation is the final pathway of acute coronary syndrome such as acute myocardial infarction and unstable angina. Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and yon Willebrand factor and it plays an important role in platelet aggregation and in the pathogenesis of acute coronary syndrome. It is known that polymorphism of the gene that encoding platelet glycoprotein IIb/IIIa(PI^A1/A2) is strongly related to acute coronary syndrome in Caucasian, but not in Koreans. We investigated relationship between platelet glycoprotein llb/Illa gene polymorphism and restenosis of coronary artery after angioplasty in Koreans. Total 371 patients(M=251. F=120) were enrolled. Angioplasty group comprised 143 patients who underwent coronary angioplasty, and in the angioplasty group, restenosis group comprised with the 65 patients who had restenotic lesion over 50% of luminal diameter in follow-up coronary angiography. Normal group comprised 153 patients who had no significant angiographic lesion and variant angina group comprised 75 patients who were positive in ergonovine test. Genomic DNA was extracted from peripheral arterial blood. To determine the frequency of P1^A1/A2 genotype, polymerase chain reaction(PCR) was done and the product was restricted with Mspl. 3%. agarrose gel electrophoresis showed restriction fragment length polymorphism. Clinical profile and risk factor were also reviewed. Among all 371 patients of study group, genotype of only one patients in restenosis group if is proven to be PI^A1/A2 heterozygote. All patients of normal study group, no restenosis group, and the other patients in restenosis group have an PI^A1 homozygote genotype. In our study, platelet glycoprotein IIb/Illa polymorphism has no relationship with restenosis of the coronary artery after angioplasty in Koreans. But the genotypic frequency of platelet glycoprotein IIb/IIIa gene polymorphism in Koreans is concordant with that of previous studies.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

溶媒添加에 따른 Ethylene Disulfide Dibenzoic Acid와 희토류 금속 ion과의 錯物에 對한 分光學的 硏究(Ⅰ).

丁學鎭,송성식,曺正煥 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

Thiosalicylic acid를 출발물질로 하여 EDDA(Ethylene disulfide dibenzoic zcid) ligand를 합성하였다. 이 ligand는 IR Spectrum과 원소 분석에 의하여 확인하였고 몇가지 희토류 금속이온과 ligand사이에 생성된 착이온의 pH 및 시간에 대한 안정성과 용매첨가에 따른 Complex ion들의 분광학적 현상을 UV분광법으로 확인하였다. 전위차분석법에 의하여 합성된 ligand의 pKa값을 정하고 complex ion들의 금속-리간드간에 존재하는 공유결합성을 ligand의 pKa값과 착이온들의 oscillator strenght 사이에서 얻어진 관계식으로부터 검토하였으며 다음과 같은 결과를 얻었다. 1. 합성된 EDDA ligand의 원소분석결과 이론치에 일치하였으며 IR Spectrum data로부터 aromatic-S-aliphatic 특성 peak와 aromatic-COOH dimer peak를 얻었다. 2. 합성된 EDDA ligand는 4자리 schiff base ligand로 행동한다. 3. 생성된 착이온의 입체적 구조변화는 hypsochromic effect를 갖는 n-π charge transfer complex이다. 4. Lanthanides(Ⅲ)와 EDDA ligand사이에 생성된 complex ion들은 1:1 complex였다. 5. 착이온들의 최대흡광파장은 결합하고 있는 중심금속의 종류에 따라 달라진다. 6. 착이온들에게 몇가지 유기용매를 첨가한 결과 complex ion들의 최대 흡광파장은 bathochromic effect를 갖는다. 7. 착이온들의 P^H 안정성은 pH 6.0∼9.0이며 lanthanides(Ⅲ)와 합성된 ligand를 몇가지 유기용매와 반응시킨때의 시간의 안정성은 30분후이다. 8. Complex ion의 안정도 상수들은 pKa값과 첨가된 용매의 종류의 변화에 따라 달랐다. 9. 착화합물들의 osillator strenght(P_ML) values와 transitonal absorption band들은 P_obs/f_m×10^5 vs。f_M/f_M의 linear dinear diagram과 거의 일치하고 이는 금속-ligand 결합이 -COOH의 산소원자와 황원자들에 의하여 형성되었음을 보여주는 것이다. Ethylene disulfide dibenzoic acid (EDDA) ligand is synthesized with starting matterial of thiosalicylic acid, this ligand is identified with IR spectrum and analytical data of carbon and hydrogen. The stability of time and pH on the complex ions formed between some rare earth metallic ions and ligand synthesized, and spectrophotometrc phenomena of complex ions formed according to the addition of solvent have been investigated by UV.-Vis. spectrophotometry. The pKa values of ligand synthesized have been obtained by the method of potentiotitrator, the covalent bonding property that is existed between metals and ligand of the complex ions has been discussed from the equations given between pKa values of ligand and oscillator strength of complex ions. The results are as follows: 1) The analytical data of hydrogen and carbon of EDDA ligand synthesized correspond with experimental values, the characteristic peaks of aromatic-aliphatic groups and peaks of aromatic-COOH dimer are shown in I R. spectrophotometric data. 2) EDDA behaves as ligand of four site-schiff base. 3) Stereostructure of complex ions formed are n-π charge transfer complexes with hypsochromic effect. 4) Complex ions formed between lanthanides(Ⅲ) and EDDA ligand are 1 : 1 complexes. 5) The λ max. of complex ions are varied depending on the centered metals bonded. 6) The λ max. of complex ions added with various kinds of solvents have bathochromic effect. 7) The pH range of stability is 6.0∼9.0, and stability of time reacted with lanthanides(Ⅲ) and ligand synthesized under various kinds of solvents is 30 minutes. 8) The stability consants of complex ions are varied with the changes of pKa and kinds of solvents added. 9) The oscillator strength(P_ML) of transitional absorption bands of complexes almost corresponds with linnear diagram of P_0bs/f_M×10^6 vs. f_ML/f_M. and these results show that metal-ligand bonding are formed by oxygen atom in rhe carboxyl groups and sulfur atoms.

몇몇 플라보노이드의 항상화활성의 비교 연구

정현균,정민아,송동업,안봉환,양성렬 全南大醫大 2000 전남의대학술지 Vol.36 No.2

毛髮 및 爪甲의 성장에 따른 단백성분의 산화

정영도,최기오,양성렬,이춘기,안봉환,이민화 한국노화학회 1992 한국노화학회지 Vol.2 No.1

시중에 판매되고 있는 아이스크림의 일반세균 및 대장균군 오염 실태

정다운,김영환,손종렬,변상훈 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.1

Ice cream is a vastly consumed food enjoyed by a wide range of people. Therefore, it is easily accessible and amounts to hundreds of its kind. Ice cream is a ready-made food which could be served without undergoing cooking process and thus putting weight on its hygienic condition. And so we set out to conduct some research on the number of E-coli bactria contained in commercially sold ice creams. We applied Lactose broth method along with Desoxycholate agar method which enables us to verify the existence of E-coli bacteria and how much is contained. We focused our research on soft ice creams and aimed to seek out the degree to which they were contaminated by E-coli bacteria. 4 major distributors of soft ice cream out of 5 didn't meet the maximum allowance of E coli bacteria to be found. The number of general bacteria observed per 1 ㎖ of specimen must be held at less than 100,000, and this wasn't violated by any of the companies' samples. Yet on E-coli testing, all of K, L, B and M companies' samples respectively exceeded the permitted limits of bacteria to be detected.

유해 정보 차단을 위한 검색 시스템

정희,이우선,정성환 창원대학교 정보통신연구소 2000 精報通信論文集 Vol.4 No.-

On the internet, enormous information is created and destroyed everyday, but we waste time and resources on searching information because we don't know which information is valid. And harmful information that gives juveniles bad influences becomes issues because juveniles accept them without proper filtration. So this study suggests a searching system to offer useful information on the internet. This searching system blocks accesses of invalid sites, and blocks harmful sites by judging whether sites are harmful or not in case that sites are valid. Therefore, this system prevents juveniles from accessing to harmful sites and always offer useful information on the internet.

관동맥 재개통 후 QTc간격분산의 감소 : 정량적으로 측정한 심근 허혈의 호전 정도와의 연관성 Relationships with the Quantitative Degree of Improvement in Myocardial Ischemia

박상선,최기준,남기병,이철환,홍멸기,박성욱,박승정,신중우,문대혁,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

곰팡이 오염된 사료를 섭취한 개에서 신부전과 calcium oxalate-like crystal

육현정,손화영,류시윤,조성환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

In March and July 2004, 2-year-old female Yorkshire Terrier and 7-year-old female Shih-Tzu were referred to the College of Veterinary Medicine, Chungnam National University. Clinically, two dogs showed anorexia, vomiting and emaciation. The signs had occurred after the dogs were fed diets infected with oxalate-producing fungi. At necropsy, Shih Tzu had severe renal damage with the green-yellowish colored uroliths in the renal pelvis and the both kidneys were extremely reduced in sizes. Microscopically, Yorkshire Terrier had acute nephritis contained necrotized and degenerated tubular epithelial cells in cortex. Numerous calcium oxalate-like crystals were infiltrated into most tubules, especially the proximal convoluted tubules. Shih Tzu showed chronic nephritis with nephrosclerosis displaced by fibrous connective tissue in most areas. The glomeruli had undergone all stages of variation such as degeneration and fibrosis.

Carbamazepine으로 인한 무과립성 백혈구증 1례

박성수,이정호,오석환 인제대학교 1986 仁濟醫學 Vol.7 No.3

발작성 이상 뇌파 소견을 지닌 정신분열증 환자에서 Carbamazepine 사용후 임상 증상과 말초 혈액 소견상 무과립성 백혈구증을 보인 증례를 치험하였기에 문헌적 고찰과 함께 이를 보고한다. Recently Carbamazepine use has been increased in psychiatry. Especially Carbamazepine has been proposed as an alternative therapy in manic-depressive illness when lithium is ineffective or cannot be used because of side effect. As Carbamazepine use is increasing in psychiatry, the psychiatric community become familiar with the adverse effects associated with Carbamazepine's side effects vary widly including a potential irreversible agranulocytosis. We experienced and treated a case of agranulocrtosis in a patient who was given Carbamazepine for schizophrenic disorder with abnormal E. E. G. finding. The it is important to undergo the regular hematological monitoring because of the Carbamazepine administration. Therefore it is important to undergo the regular hematological monitoring because of the severity of the hematological adverse effect, though it is rare. And it is also important to discontinue the medication immediately and to treat intensively agranulocytosis.