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Thioredoxin-interacting protein, hematopoietic stem cells, and hematopoiesis
Jung, Haiyoung,Choi, Inpyo CURRENT SCIENCE 2014 CURRENT OPINION IN HEMATOLOGY Vol.21 No.4
PURPOSE OF REVIEW: Reactive oxygen species (ROS) can regulate diverse signaling pathways and functions in hematopoietic cells. Thioredoxin-interacting protein (TXNIP) plays an important role in mammalian cells by inhibiting thioredoxin (TRX) under oxidative stress conditions. TXNIP is expressed in hematopoietic stem cells (HSCs), and its expression decreases as HSCs differentiate into precursor cells. However, this reduction in expression does not sufficiently explain the function of TXNIP in hematopoietic cells under oxidative stress conditions. Here, we review how ROS can regulate hematopoiesis by focusing on the function of TXNIP in hematopoietic cells under oxidative stress conditions. RECENT FINDINGS: Studies of Txnip mice have demonstrated an antioxidant function of TXNIP in hematopoietic cells or immune cells. This antioxidant function differs from the conventional pro-oxidant activity of TXNIP observed in other cell types under oxidative stress. The data suggest a context-dependent function of TXNIP under oxidative stress conditions and, in particular, a differential function of TXNIP in hematopoietic cells via its direct interaction with other redox regulatory proteins. SUMMARY: The regulation of ROS is important in determining cellular fate decisions. TXNIP acts as a negative regulator of TRX via direct interaction, and it increases the levels of ROS under oxidative stress. However, TXNIP has an antioxidant function in hematopoietic cells or immune cells, as ROS levels are elevated and induce apoptosis in Txnip hematopoietic cells. These results suggest that the amount of TXNIP is inversely associated with ROS levels, and the loss of TXNIP can increase ROS levels in immune cells or hematopoietic cells.
Haiyoung Son,Hak Min Lee,Yun-Jung Yang,Hyun Jo Youn,Jong Won Lee,Jihyoun Lee,So Youn Jung,Min Hyuk Lee,Ilkyun Lee 한국유방암학회 2020 Journal of Breast Disease Vol.8 No.2
Purpose: This study aimed to investigate and analyze the current fertility-related practices for breast cancer patients; the results are intended to help improve the quality of life of young patients and survivors. Methods: This study collected voluntary responses to a questionnaire that was used to survey Korean breast cancer specialists. The questionnaire consisted of five categories: knowledge, practice behaviors regarding fertility preservation, barriers to discussing fertility preservation, attitude toward fertility issues, and demographics and medical background. Results: A total of 120 copies of the questionnaire were distributed; the response rate was 89%. The section of the questionnaire regarding knowledge indicated that most respondents had adequate fertility preservation knowledge for cancer patients. However, 13.1% of the respondents indicated that they thought pregnancy increased the cancer recurrence risk. Respondents’ knowledge and attitudes about fertility preservation were not correlated with actual practice. The absence of patient’s expressions (24.30%), high recurrence risk (27.10%), insufficient time in the clinic (21.50%), and hospital conditions such as no reproductive specialists or infertility clinic (16.82%), were considered major barriers to discussing fertility issues. Conclusion: Although more than 50% of the respondents thought that cancer treatment is more important than fertility preservation and it is complex and difficult, the Korean breast surgical oncologists were generally encouraging when discussing fertility issues with young breast cancer patients. Hence, breast clinicians should share with young patients the updated evidence regarding the feasibility and safety of pregnancy after cancer treatment and the available options so that the best decisions can be made.
Jung, Haiyoung,Seong, Hyun-A,Ha, Hyunjung American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.50
<P>Murine protein serine/threonine kinase 38 (MPK38) is a member of the AMP-activated protein kinase-related serine/threonine kinase family that plays an important role in various cellular processes, including cell cycle, signaling pathways, and self-renewal of stem cells. Here we demonstrate a functional association between MPK38 and apoptosis signal-regulating kinase 1 (ASK1). The physical association between MPK38 and ASK1 was mediated through their carboxyl-terminal regulatory domains and was increased by H(2)O(2) or tumor necrosis factor alpha treatment. The use of kinase-dead MPK38 and ASK1 mutants revealed that MPK38-ASK1 complex formation was dependent on the activities of both kinases. Ectopic expression of wild-type MPK38, but not kinase-dead MPK38, stimulated ASK1 activity by Thr(838) phosphorylation and enhanced ASK1-mediated signaling to both JNK and p38 kinases. However, the phosphorylation of MKK6 and p38 by MPK38 was not detectable. In addition, MPK38-mediated ASK1 activation was induced through the increased interaction between ASK1 and its substrate MKK3. MPK38 also stimulated H(2)O(2)-mediated apoptosis by enhancing the ASK1 activity through Thr(838) phosphorylation. These results suggest that MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1.</P>
Development of a Forest Fire Detection System Using a Drone-based Convolutional Neural Network Model
Jihee Lee(Jihee Lee),Keesin Jeong(Keesin Jeong),Haiyoung Jung(Haiyoung Jung) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.2
Considering forest fires cause environmental destruction, ecosystem collapse, and severe damage to human lives and nature, developing a real-time, accurate, and stable forest fire detection system has become a critical issue in modern society. In this study, a drone-based forest fire detection system was developed using a convolutional neural network (CNN) model. Real-time forest fire detection models were developed using the CNN-based MobileNet algorithm, and their fire detection performance was evaluated. The main research results indicated that errors decreased and accuracy tended to increase during the model training and validation process as training progressed. Moreover, the V1 model exhibited the highest validation accuracy of 0.9466 among the MobileNet V1, V2, and V3 models and showed the highest accuracy of 0.9667 in evaluating the new test dataset during the model evaluation process.
Jiwon Choi(Jiwon Choi),Keesin Jeong(Keesin Jeong),Haiyoung Jung(Haiyoung Jung) 한국화재소방학회 2022 International Journal of Fire Science and Engineer Vol.36 No.4
Dust and fine dust exist in various forms and can lead to various problems such as dust explosion and air pollution. To reduce them, recently, research on electrospray electric precipitation, among various dust collection methods, has been actively conducted. In this study, comparative analysis experiments were performed on microdroplet generation characteristics for direct and indirect charging methods of electrospray electric precipitation. A visualization device was fabricated to generate microdroplets, and microdroplets were photographed with a high-magnification camera according to each charging method. The size and number of microdroplets were then analyzed via ImageJ software.