Decreased <i>DBC1</i> Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer

Shim, Ui Jae,Lee, Il-Seok,Kang, Ho Won,Kim, Jayoung,Kim, Won Tae,Kim, Isaac Yi,Ryu, Keun Ho,Choi, Yung Hyun,Moon, Sung-Kwon,Kim, Yong-June,Yun, Seok-Joong,Lee, Sang-Cheol,Kim, Wun-Jae The Korean Urological Association 2013 Korean Journal of Urology Vol.54 No.9

<P><B>Purpose</B></P><P>The deleted in bladder cancer 1 (<I>DBC1</I>) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of <I>DBC1</I> as a prognostic marker in BC.</P><P><B>Materials and Methods</B></P><P>The expression of <I>DBC1</I> was determined by real-time polymerase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of <I>DBC1</I> was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model.</P><P><B>Results</B></P><P><I>DBC1</I> expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower <I>DBC1</I> expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low <I>DBC1</I> expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of <I>DBC1</I> expression in NMIBC (log-rank test, each, p<0.05).</P><P><B>Conclusions</B></P><P>The expression of <I>DBC1</I> was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that <I>DBC1</I> expression can be a useful prognostic marker for patients with NMIBC.</P>

Evaluation of Mechanical Properties of Three-dimensional Printed Flexible Denture Resin according to Post-polymerization Conditions: A Pilot Study

Sang-Yub Lee,Jung-Hwa Lim,June-Sung Shim,Jong-Eun Kim 대한치의학회 2022 Journal of korean dental science Vol.15 No.1

Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms

Shim, Kang Hee,Kim, Tae Woo,Chung, Byung Ha,Lee, Sung Won,Park, Jong Kwan,Park, Kwangsung,Cheon, Jun,Lee, Kyung Seop,Kim, Hyung-Jee,Seong, Do-Hwan,Oh, Seung-June,Kim, Sae Woong,Lee, Ji Youl,Choo, Seol The Korean Urological Association 2018 Investigative and Clinical Urology Vol.59 No.1

<P><B>Purpose</B></P><P>To determine changes in autonomic nervous system activity after treatment in men with lower urinary tract symptoms (LUTS), we evaluated changes in patients' symptoms, uroflowmetry, and heart rate variability (HRV) after treatment with alpha-blockers for 12 weeks.</P><P><B>Materials and Methods</B></P><P>Ninety-five men who had LUTS (International Prostate Symptom Score [IPSS] ≥8) were included in this study. We divided them into two groups on the basis of a low frequency/high frequency (LF/HF) ratio of 1.6. After treatment with Xatral XL (Handok Inc., Korea) 10 mg for 3 months, we rechecked their IPSS, uroflowmetry, HRV and compared these with the baseline measurements.</P><P><B>Results</B></P><P>Fifty-four men were assigned to the low LF/HF group (group A: LF/HF ≤1.6) and 41 men to the high LF/HF group (group B: LF/HF >1.6). At baseline and 12 weeks, none of the parameters differed significantly between the groups except for HF, which is one of the parameters of HRV. IPSS, the IPSS-voiding subscore, and the IPSS-storage subscore decreased and maximal uroflow increased significantly after 12 weeks of treatment. Whereas the baseline LF/HF ratio increased from 0.89±0.407 to 1.80±1.804 after treatment in group A, it decreased from 3.93±5.471 to 1.79±1.153 in group B.</P><P><B>Conclusions</B></P><P>The efficacies of Xatral XL were clear in both groups. We found that the LF/HF ratio in the two groups merged to a value of approximately 1.79 after treatment. We suggest that this could be a clue to the importance of balance in autonomic nervous system activity in men with LUTS.</P>

Oceanisphaera avium sp. nov., isolated from the gut of the cinereous vulture, Aegypius monachus

Sung, Hojun,Kim, Hyun Sik,Lee, June-Young,Kang, Woorim,Kim, Pil Soo,Hyun, Dong-Wook,Tak, Euon Jung,Jung, Mi-Ja,Yun, Ji-Hyun,Kim, Min-Soo,Shin, Na-Ri,Whon, Tae Woong,Rho, Jeong Rae,Park, Sun Duk,Shim, Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.6

THE FRACTURE CHARACTERISTICS OF GLASS FIBER POST AND CORE ON USING DIFFERENT TYPES OF CORE RESIN MATERIALS

Shim Dong-Wook,Shim June-Sung,Lee Seok-Hyung,Lee Keun-Woo The Korean Academy of Prosthodonitics 2004 대한치과보철학회지 Vol.42 No.3

Statement of problem. Glass fiber post is one of recent developments to accommodate esthetic restoration for endodontically treated teeth. This has many advantages over conventional post system in physical properties, esthetic factor, risk of root and restoration fracture, adhesion to core, radiopacity, removal and retrievabilty, biocompatibility and chemical stability. Purpose. This in vitro study was to evaluate the most suitable type of resin core for the glass fiber post through surveying the fracture modes and the maximum load that fractures the tooth. Material and methods. 50 sound maxillary premolars restored with glass fiber posts($ParaPost^{(R)}$ Fiber White) and different types of resin cores(ParaCore, $Z100^{TM}$, $Rebilda^{(R)}$ and $Admira^{(R)}$) were prepared and loaded to faiure in a universal test machine. The maximum fracture load and fracture mode were investigated in the specimens that were restored with resin and those of metal cast and core. With the data, Wilcoxon rank sum test was used to validate the significance between the test groups, and Tukey' s studentized range test was used to check if there is any significant statistical difference between each test group. Every analysis was approved with 95% reliance. Results. On measuring the maximum fracture load of teeth specimens, there was a significant difference between the maximum fracture loads of the tooth specimens. ParaCore showed the highest mean maximum fracture load followed by $Z100^{TM}$. And, the distribution of fracture mode of tooth specimens showed generally Type D, the three parted fracture of the core around the post was mostly seen(62.5%), and specifically, ParaCore showed 90% and $Z100^{TM}$ showed 100% Type D fracture. Conclusion. Referring to the values of maximum fracture load and mean compressive fracture load, ParaCore and $Z100^{TM}$ had high values and are recommended as tooth colored resin core material for glass fiber post. CLINICAL IMPLICATIONS. This study was carried out intending to be of aid in selecting the appropriate resin core for the glass fiber post. The dual cure type composite resin ParaCore and light cure type composite resin $Z100^{TM}$ have good properties and are recommended as tooth colored resin core material for glass fiber post.

Tumebacillus avium sp. nov., isolated from the gut of a cinereous vulture, Aegypius monachus

Sung, Hojun,Kim, Hyun Sik,Lee, June-Young,Kang, Woorim,Kim, Pil Soo,Hyun, Dong-Wook,Tak, Euon Jung,Jung, Mi-Ja,Yun, Ji-Hyun,Kim, Min-Soo,Shin, Na-Ri,Whon, Tae Woong,Rho, Jeong Rae,Park, Sun Duk,Shim, Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.5

An Integrated Circuit for Biphasic Pulse Generator with Variable Parameters

Shinyong Shim,Jaehoon Sung,Sung June Kim 대한전자공학회 2021 Journal of semiconductor technology and science Vol.21 No.4

A biphasic pulse generator integrated circuit (IC) was designed, and the parameters of the generated pulses such as pulse rate, duration, and amplitude were adjusted to the desired values by using the time-varying differences of two inputs of the operational amplifier integrated on the IC. The chip was fabricated with the MagnaChip /SK Hynix CMOS 0.35 ㎛ process, which allowed a maximum pulse amplitude of 3.3 V. In addition, it included a transformer that allowed the IC to rectify the amplitude modulated (AM) input with a 1 ㎓ carrier and provide the supply voltage to generate the pulses. The whole size of the full system was 441.5 ㎛×527.8 ㎛, and the system successfully generates biphasic pulses up to 1.2 ㎑ using the RF signal. This circuit can be used to generate biphasic pulses with variable parameters for distributed neural interfaces, and to provide scan voltages for potentiostat applications such as in the Fast Scan Cyclic Voltammetry (FSCV). In addition, this IC with an integrated transformer suggests that a wireless electroanalytical system on a chip can be achieved as a future work.

위식도역류질환에 대한 국내 인터넷 의료 정보 평가

이준상 ( June Sang Lee ),문태건 ( Tae Gun Moon ),김회진 ( Hoi Jin Kim ),이현정 ( Hyun Jeong Lee ),이준행 ( Jun Haeng Lee ),심상군 ( Sang Goon Shim ),이풍렬 ( Poong Lyul Rhee ),김재준 ( Jae J. Kim ),이종철 ( Jong Chul Rhee ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.4

목적: 인터넷상에서 위식도역류질환에 대해서 검색되는 웹사이트들이 정확한 의료 정보를 제공하고 있는지 평가하였으며 이를 통해 위식도역류질환에 대한 인터넷 정보의 지향점을 제시하고자 하였다. 대상 및 방법: "위식도역류질환"과 "역류(성) 식도염"을 핵심 단어로 2006년 7월 1일부터 9월 2일까지 7개의 검색엔진에서 검색된 각각 상위 15개 웹사이트(총 108개)를 대상으로 JAMA 핵심기준과 대한소화기 운동학회의 위식도역류질환의 진단, 치료 가이드라인을 참조하여 만든 점검표를 이용해서 평가하였다. 결과: 전체 108개의 사이트 중 개인 병의원의 검색 빈도가 가장 높았고(21.3%) 대부분 환자나 일반인을 대상으로 하고 있었다(87.0%). JAMA 기준에 3개 이상 부합하는 사이트는 11개(9.3%)였고 3개 미만으로 만족시킨 웹사이트보다 정보의 불확실성이 유의하게 더 낮았다(p=0.002). "Heartburn"에 대한 정의는 50%의 웹사이트에서 비교적 정확히 언급되었고 진단 시 초기에 위내시경 검사를 시행한다고 언급한 사이트는 48.1%, 내시경 검사 없이 24시간 pH 검사 등을 초기에 시행한다는 언급은 26.9%, 식도내압 검사나 번스타인 검사, 식도조영술을 일반적으로 시행한다고 언급한 웹사이트는 28.7%였다. 치료에서는 65.7%에서 생활습관 조정을 언급하였고 생활습관 조정 단독만으로 증상 관해를 유도할 수 있다는 웹사이트는 47.2%였다. 치료약물 중 양성자펌프억제제를 언급한 웹사이트는 57.3%였는데 임상적으로 가벼운 경우에 양성자펌프억제제 4주 투여 후 필요 시 투여나 단계적 하향 투여에 대한 언급은 8.3%, 임상적으로 심한 경우에 양성자펌프 억제제 8주 투여 후 지속 투여에 대한 언급은 11.1%의 웹사이트에서 있었다. 결론: 일반인들이 검색엔진을 통하여 접근할 수 있는 인터넷에서 사이트에서 제공되는 위식도역류질환 진단과 치료에 대한 정보는 대부분 기초적인 수준에 머물러 있었고, 구체적인 부분에서는 사이트마다 정보의 양과 내용에서 차이가 많았다. 이는 인터넷에서 정보를 구하고자 하는 환자에게 적지 않은 혼란을 초래할 수 있을 것으로 판단한다. Background/Aims: Internet has become an important source of medical information not only for medical personnels but also for patients. The aim of this study was to evaluate the quality of internet based medical information about ``gastroesophageal reflux`` or ``reflux esophagitis`` in Korea. Methods: The first 15 internet sites using the key words ``gastroesophageal reflux`` or ``reflux esophagitis`` were retrieved from the 7 most frequently used internet search engines. The quality of information from a total of 108 websites was evaluated using a checklist. Results: Among total 108 sites related to ``gastroesophageal reflux`` or ``reflux esophagitis``, fifty-six sites (51.8%) were made by hospitals or clinics and 94 sites (87.0%) were made for patients. Of the 108 sites, eleven web sites (10.1%) had more than three JAMA benchmarks (authorship, references, currency, and disclosure). Higher quality sites (at least three JAMA benchmarks) were less likely to contain inaccurate information than lower quality sites (fewer than three JAMA benchmarks)-3/11 (27.2%) vs. 60/97 (61.9%) (p<0.01). Despite the fact that articles in the literature emphasized an insufficient evidence to support an association between the lifestyle, dietary behaviors, and GERD, such guidelines continue to be recommended as first-line therapy in most websites. Conclusions: Informations about gastroesophageal reflux disease were incomplete in the majority of medical web sites. These would bring about confusion to patients seeking for an information about GERD through the internet. There is a need for better sources in evidence based informations about gastroesophaeal reflux diseases on the web. (Korean J Gastroenterol 2007;49:231-237)

모성 심 질환이 동반된 임신의 임상양상

윤상호(Sang Ho Yoon),천은경(Eun Kyung Chun),심순섭(Soon Sup Shim),임준희(June Hee Lim),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

Objective : To assess the pregnancy outcomes complicated by maternal heart diseases. Methods : From 1994 to 2001, medical records of pregnant women who had reached at least 20 weeks of gestation with maternal heart diseases were reviewed. Results : 224 deliveries of 195 women were enrolled in this study. In 117 (52.2%) cases the heart diseases were of rheumatic origin, in 96 (42.9%) cases congenital, and the remaining 11 (4.9%) cases were miscellaneous group that included arrhythmia, cardiomyopathy, and mitral valve prolapse. There were 2 (0.9%) cases of maternal death related to pregnancy. Majority (91.9%) were in New York Heart Association functional classes I, Ⅱ before, during, and after delivery. Mean gestational age at birth and birth weight were 37.9 weeks and 2883 gm. Perinatal mortality rate was 17.9/1000 and the rate of congenital malformation was 2.7%. Recurrence risk of neonatal congenital heart disease was 2.1%. Conclusion : Most complications were developed in the pregnancies complicated by maternal heart diseases with New York Heart Association functional classes Ⅲ, Ⅳ. Functional status of the pregnant women is the important risk factor in maternal and fetal outcomes.

SQL2 적합성 시험도구의 설계 및 구현

이상호(Sang Ho Lee),이상구(Sang-goo Lee),심준호(June Ho Shim) 한국정보과학회 1996 정보과학회 컴퓨팅의 실제 논문지 Vol.2 No.3

DBMS 기능시험은 DBMS마다 그 기능이 상이하므로 DBMS 인터페이스격인 SQL의 적합성 시험을 통한 방법이 일반적이다. SQL 적합성 시험도구는 DBMS SQL 구현의 정확성을 시험함으로써 DBMS 기능시험을 목적으로 한다. 본 논문에서는 기능 시험도구로서 SQL 적합성 시험도구인 설계 및 구현에 대해 기술한다. 시험항목들은 완전성, 독립성, 자체 평가성, 명확성, 확장성, 편리성을 가지도록 설계 및 구현되었으며 SQL 표준안(SQL2)의 완전수준을 시험범위로 하였다. 개발된 시험도구는 660개 이상의 개별 시험항목을 제공하며, 바다 Ⅱ DBMS의 기능 시험용으로 구현되었으나 타 DBMS의 SQL2의 적합성 시험에도 이용할 수 있다. Due to different functionalities supported by various DBMS systems, it is quite difficult to define a standard functionality test for DBMS. For this reason, conformance to the industry standard interface language SQL is generally used as a basis to verifying the functionality of a DBMS. The objective of such a testing tool is to verify semantics and syntax of an SQL implementation of DBMS. In this paper, we present the design and implementation of an SQL conformance testing tool for relational DBMSs. The test is designed for ISO SQL2 Full Level and each test item has been generated with the criteria of independence, self-evaluation, clarity, extensibility and convenience. The testing tool offers over 660 individual test items and has been developed primarily for the BADA Ⅱ DBMS, although it can also serve as an SQL2 conformance test for other DBMS.